trichlorfon has been researched along with Nervous System Diseases in 12 studies
Trichlorfon: An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed)
trichlorfon : A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hens given leptophos and TOCP demonstrated delayed neuropathy with obvious inhibition of NTE, but the times of onset and the degrees of peak inhibition of NTE activity were different: 6-24 hours after dosing and 73-82% of normal activity for leptophos, and 24-48 hours and 45-80% for TOCP, respectively." | 1.30 | Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens. ( Piao, FY; Tian, Y; Xie, XK; Yamauchi, T, 1998) |
| "Leptophos was used as a reference neurotoxic agent." | 1.30 | Neurotoxic potential of six organophosphorus compounds in adult hens. ( Abdelsalam, EB, 1999) |
| " In hens double doses of trichlorphon each exceeding unprotected LD50 can produce moderate neuropathy associated with appropriately high inhibitions of neurotoxic esterase." | 1.26 | Delayed neurotoxicity - do trichlorphon and/or dichlorvos cause delayed neuropathy in man or in test animals? ( Johnson, MK, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (75.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baldissera, MD | 1 |
| Souza, CF | 1 |
| Descovi, SN | 1 |
| Zanella, R | 1 |
| Prestes, OD | 1 |
| da Silva, AS | 1 |
| Baldisserotto, B | 1 |
| Shiraishi, S | 2 |
| Inoue, N | 2 |
| Murai, Y | 1 |
| Onishi, A | 1 |
| Noda, S | 1 |
| Vasilescu, C | 2 |
| Alexianu, M | 1 |
| Dan, A | 1 |
| Shono, T | 1 |
| Horio, M | 1 |
| Johnson, MK | 1 |
| Florescu, A | 1 |
| Tian, Y | 1 |
| Xie, XK | 1 |
| Piao, FY | 1 |
| Yamauchi, T | 1 |
| Abdelsalam, EB | 1 |
| Holmstedt, B | 1 |
| Nordgren, I | 1 |
| Sandoz, M | 1 |
| Sundwall, A | 1 |
| Olajos, EJ | 1 |
| Rosenblum, I | 1 |
| Coulston, F | 1 |
| Strominger, N | 1 |
| Irányi, J | 1 |
| Berge, GN | 1 |
| Nafstad, I | 1 |
| Fonnum, F | 1 |
1 review available for trichlorfon and Nervous System Diseases
| Article | Year |
|---|---|
Metrifonate. Summary of toxicological and pharmacological information available.
Topics: Animals; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Dichlorvos; Humans; Intestinal Ab | 1978 |
1 trial available for trichlorfon and Nervous System Diseases
| Article | Year |
|---|---|
Organophosphate pesticide trichlorfon induced neurotoxic effects in freshwater silver catfish Rhamdia quelen via disruption of blood-brain barrier: Implications on oxidative status, cell viability and brain neurotransmitters.
Topics: Acetylcholinesterase; Animals; Blood-Brain Barrier; Brain; Catfishes; Cell Survival; Dichlorvos; Dos | 2019 |
10 other studies available for trichlorfon and Nervous System Diseases
| Article | Year |
|---|---|
Dipterex (Trichlorfon) poisoning. Clinical and pathological studies in human and monkeys.
Topics: Adult; Animals; Female; Humans; Macaca fascicularis; Middle Aged; Muscular Atrophy; Nervous System D | 1983 |
Delayed neuropathy after organophosphorus insecticide (Dipterex) poisoning: a clinical, electrophysiological and nerve biopsy study.
Topics: Adult; Biopsy; Electromyography; Evoked Potentials; Female; Humans; Male; Nervous System Diseases; N | 1984 |
[Delayed neurotoxicity of Dipterex (trichlorfon)--unsuccessful trials on various animals].
Topics: Animals; Chickens; Cricetinae; Disease Models, Animal; Muridae; Nervous System Diseases; Trichlorfon | 1982 |
Delayed neurotoxicity - do trichlorphon and/or dichlorvos cause delayed neuropathy in man or in test animals?
Topics: Animals; Chickens; Dichlorvos; Drug Contamination; Humans; Lethal Dose 50; Nervous System Diseases; | 1981 |
Clinical and electrophysiological study of neuropathy after organophosphorus compounds poisoning.
Topics: Adult; Dichlorvos; Electrophysiology; Evoked Potentials; Female; Humans; Insecticides; Male; Middle | 1980 |
Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens.
Topics: Acetylcholinesterase; Animals; Carboxylic Ester Hydrolases; Chickens; Female; Injections, Intravenou | 1998 |
Neurotoxic potential of six organophosphorus compounds in adult hens.
Topics: Animals; Brain; Chickens; Coumaphos; Diazinon; Dichlorvos; Esterases; Female; Leptophos; Nervous Sys | 1999 |
The dose-response relationship of trichlorfon neurotoxicity in hens.
Topics: Animals; Brain; Chickens; Dose-Response Relationship, Drug; Esterases; Female; Lethal Dose 50; Nervo | 1979 |
[Cases of polyneuropathy following organic phosphate ester poisoning].
Topics: Animals; Encephalomyelitis; Humans; Hungary; Insecticides; Lethal Dose 50; Nervous System Diseases; | 1975 |
Prenatal effects of trichlorfon on the guinea pig brain.
Topics: Animals; Brain Diseases; Cerebellum; Cerebral Cortex; Choline O-Acetyltransferase; Female; Glutamate | 1986 |