trichlorfon has been researched along with Aging in 13 studies
Trichlorfon: An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed)
trichlorfon : A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The changes in extracellular acetylcholine levels were investigated by microdialysis in the cortex and hippocampus of aging rats after administration of metrifonate (80 mg/kg), rivastigmine (0." | 3.71 | Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats. ( Bellucci, A; Casamenti, F; Costagli, C; Pepeu, G; Scali, C; Schmidt, B, 2002) |
| "The efficacy of metrifonate, a well-tolerated cholinesterase (ChE) inhibitor, in attenuating the normal aging- and corticosterone-induced impairments of radial maze performance of rats was compared." | 3.69 | Effects of metrifonate on radial arm maze acquisition in middle-aged rats. ( Dachir, S; Levy, A; Schmidt, B, 1997) |
| "Thiabendazole was used more often (9 tests) than the other compounds." | 2.67 | Controlled tests of activity of several antiparasitic compounds against natural infections of Haemonchus contortus and other helminths in lambs from a flock established in 1962. ( Drudge, JH; Lyons, ET; Stamper, S; Tolliver, SC, 1993) |
| "Nimodipine treatment decreased cortical high voltage spindles (HVSs) in aged rats, but did not prevent the diminution of spontaneous locomotor activity." | 1.30 | Chronic nimodipine and acute metrifonate treatment decreases age-related cortical high voltage spindles in rats. ( Björklund, M; Jäkälä, P; Koivisto, E; Riekkinen, P; Schmidt, B, 1997) |
| " However, in young rats metrifonate over a broad dosage range (10-100 mg/kg, p." | 1.29 | Metrifonate improves spatial navigation and avoidance behavior in scopolamine-treated, medial septum-lesioned and aged rats. ( Kuitunen, J; Riekkinen, M; Riekkinen, P; Schmidt, B; Stefanski, R, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scali, C | 3 |
| Casamenti, F | 1 |
| Bellucci, A | 1 |
| Costagli, C | 1 |
| Schmidt, B | 8 |
| Pepeu, G | 3 |
| Disterhoft, JF | 5 |
| Matthew Oh, M | 1 |
| Lyons, ET | 1 |
| Drudge, JH | 1 |
| Tolliver, SC | 1 |
| Stamper, S | 1 |
| Bassant, MH | 1 |
| Jazat-Poindessous, F | 1 |
| Lamour, Y | 1 |
| Riekkinen, P | 2 |
| Stefanski, R | 1 |
| Kuitunen, J | 1 |
| Riekkinen, M | 1 |
| Kronforst-Collins, MA | 2 |
| Moriearty, PL | 3 |
| Ralph, M | 1 |
| Becker, RE | 1 |
| Thompson, LT | 2 |
| Jäkälä, P | 1 |
| Koivisto, E | 1 |
| Björklund, M | 1 |
| Giovannini, MG | 2 |
| Bartolini, L | 2 |
| Prosperi, C | 1 |
| Hinz, V | 1 |
| Dachir, S | 1 |
| Levy, A | 1 |
| Oh, MM | 2 |
| Power, JM | 2 |
1 trial available for trichlorfon and Aging
| Article | Year |
|---|---|
Controlled tests of activity of several antiparasitic compounds against natural infections of Haemonchus contortus and other helminths in lambs from a flock established in 1962.
Topics: Aging; Animals; Anthelmintics; Benzimidazoles; Cambendazole; Drug Combinations; Fenbendazole; Haemon | 1993 |
12 other studies available for trichlorfon and Aging
| Article | Year |
|---|---|
Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats.
Topics: Acetylcholine; Aging; Animals; Body Weight; Brain; Carbamates; Cerebral Cortex; Cholinesterase Inhib | 2002 |
Modulation of cholinergic transmission enhances excitability of hippocampal pyramidal neurons and ameliorates learning impairments in aging animals.
Topics: Aging; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Hippocampus; Lea | 2003 |
Effects of metrifonate, a cholinesterase inhibitor, on local cerebral glucose utilization in young and aged rats.
Topics: Aging; Animals; Autoradiography; Brain; Cholinesterase Inhibitors; Deoxyglucose; Dichlorvos; Kinetic | 1996 |
Metrifonate improves spatial navigation and avoidance behavior in scopolamine-treated, medial septum-lesioned and aged rats.
Topics: Aging; Animals; Avoidance Learning; Cholinesterase Inhibitors; Male; Motor Activity; Rats; Rats, Wis | 1996 |
Metrifonate treatment enhances acquisition of eyeblink conditioning in aging rabbits.
Topics: Aging; Animals; Blinking; Brain; Cholinesterase Inhibitors; Cholinesterases; Conditioning, Classical | 1997 |
Chronic nimodipine and acute metrifonate treatment decreases age-related cortical high voltage spindles in rats.
Topics: Aging; Animals; Calcium Channel Blockers; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism | 1997 |
Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats.
Topics: Acetylcholine; Administration, Oral; Aging; Alzheimer Disease; Animals; Brain; Cerebral Cortex; Chol | 1997 |
Metrifonate improves associative learning and retention in aging rabbits.
Topics: Acetylcholinesterase; Aging; Animals; Association Learning; Cholinesterase Inhibitors; Conditioning, | 1997 |
Effects of metrifonate on radial arm maze acquisition in middle-aged rats.
Topics: Age Factors; Aging; Animals; Anti-Inflammatory Agents; Cerebral Cortex; Cholinesterase Inhibitors; C | 1997 |
Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats.
Topics: Acetylcholine; Administration, Oral; Aging; Animals; Blood Pressure; Body Weight; Cerebral Cortex; C | 1998 |
Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus.
Topics: Action Potentials; Aging; Animals; Atropine; Carbachol; Cholinergic Agonists; Cholinesterase Inhibit | 1999 |
Metrifonate decreases sI(AHP) in CA1 pyramidal neurons in vitro.
Topics: Action Potentials; Aging; Animals; Cholinesterase Inhibitors; Female; Hippocampus; In Vitro Techniqu | 2001 |