tricetin and Parkinson-Disease

tricetin has been researched along with Parkinson-Disease* in 1 studies

Other Studies

1 other study(ies) available for tricetin and Parkinson-Disease

ArticleYear
Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway.
    Toxicology and applied pharmacology, 2019, 09-01, Volume: 378

    Apoptosis of DA neurons is a contributing cause of disability and death for Parkinson's disease (PD). In this experiment, the neuroprotective effect of Tricetin was examined in PD models both in vitro and in vivo. The results suggested that 6-OHDA-induced cytotoxicity was accompanied by an increase in ROS generation, an increase in caspase-3 protein activity, an increase in Lactate dehydrogenase (LDH) release and an increase in the ratio of Bax/Bcl-2, but the pretreatment with Tricetin significantly improved cell viability and suppressed mitochondria-mediated apoptosis. Moreover, Tricetin also induced the protein expression of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and its transcriptional activation, resulting in the up-regulated expression of heme oxygenase-1 (HO-1), which conferred neuroprotection against 6-OHDA-induced oxidative damage. Results from molecular docking indicated that Tricetin could be a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Finally, in vivo findings were confirmed in the 6-OHDA-PD C. elegans model. Thus, Tricetin may be an attractive therapeutic candidate for the neuroprotection.

    Topics: Animals; Antioxidant Response Elements; Apoptosis; Caenorhabditis elegans; Cell Line, Tumor; Chromones; Heme Oxygenase-1; Humans; Kelch-Like ECH-Associated Protein 1; Mitochondria; Molecular Docking Simulation; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Oxidopamine; Parkinson Disease; Signal Transduction

2019