tribulus and Skin-Neoplasms

tribulus has been researched along with Skin-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for tribulus and Skin-Neoplasms

ArticleYear
Saponins from Tribulus terrestris L. protect human keratinocytes from UVB-induced damage.
    Journal of photochemistry and photobiology. B, Biology, 2012, Dec-05, Volume: 117

    Chronic exposure to solar UVB radiation damages skin, increasing the risk to develop cancer. Hence the identification of compounds with a photoprotective efficacy is essential. This study examined the role of saponins derived from Tribulus terrestris L. (TT) on the modulation of apoptosis in normal human keratinocytes (NHEK) exposed to physiological doses of UVB and to evaluate their antitumoral properties. In NHEK, TT saponins attenuate UVB-induced programmed cell death through inhibition of intrinsic apoptotic pathway. In squamous cell carcinomas (SCC) TT saponins do not make the malignant keratinocytes more resistant to UVB and determine an enhanced apoptotic response. The photoprotective effect of TT saponins is tightly correlated to the enhancement of NER genes expression and the block of UVB-mediated NF-κB activation. Collectively, our study shows experimental evidence that TT has a preventive efficacy against UVB-induced carcinogenesis and the molecular knowledge on the mechanisms through which TT saponins regulate cell death suggests great potential for TT to be developed into a new medicine for cancer patients.

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Disease Progression; DNA Repair; Epidermal Cells; Gene Expression Regulation; Humans; Keratinocytes; NF-kappa B; Pyrimidine Dimers; Saponins; Signal Transduction; Skin Neoplasms; Tribulus; Ultraviolet Rays

2012