tribulus and Carcinoma--Renal-Cell

To investigate the effect of saponins from Tribulus terrestris (STT) on the renal carcinoma cell (786-0) in vitro, and inhibitory mechanisms.. Effects of SIT on the cytotoxicity, morphological changes of apoptosis, cell cycle and expression of Bcl-2 protein in the 786-0 were tested respectively by MTT method, Wright and acridine orange stain assay, as well as flow cytometry (FCM).. After the 786-0 was treated by STY, it was shown that: 1) A significant cytotoxic effect was observed by MTT assay; 2) Apoptosis-induced was viewed by Wright and acridine orange stain assay; 3) The distribution of 786-0 on S phase was increased; 4.) The expression of Bcl-2 protein and cyclin D1 was decreased.. STT can significantly inhibit the growth of 786-0 in vitro, partially, by apoptosis.

Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Drugs, Chinese Herbal; Humans; Kidney Neoplasms; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; S Phase; Saponins; Tribulus