triazulenone and Anxiety-Disorders

Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Sleep Initiation and Maintenance Disorders; Time Factors; Triazolam

A double-blind trial was carried out in 40 anxious in-patients with insomnia to compare the hypnotic effectiveness and tolerance of loprazolam, 1 mg and 2 mg, versus placebo. Groups of 10 patients received one or other dose of loprazolam or placebo for 7 nights and then placebo for the following 3 nights. Sleep quality and morning residual effects were assessed each morning during the 10-day trial period by means of a sleep questionnaire. The results showed that 1 mg loprazolam was superior to placebo but less effective than 2 mg loprazolam. No side-effects were reported at either dose level.

Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Placebos; Random Allocation; Sleep Initiation and Maintenance Disorders

Topics: Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Female; Half-Life; Humans; Male; Middle Aged; Substance Withdrawal Syndrome; Triazolam

Topics: Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Half-Life; Humans; Triazolam