triazolam and Sleep Wake Disorders studies

Triazolam: A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.

Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.

Research Excerpts

Excerpt	Relevance	Reference
"Patients with chronic orofacial pain often report disturbances in sleep, leading to the hypothesis that nocturnal motor hyperactivity of the muscles of mastication may contribute to the nociceptive process."	2.69	Triazolam improves sleep but fails to alter pain in TMD patients. ( DeNucci, DJ; Dionne, RA; Sobiski, C, 1998)
"1."	2.69	Comparison of the effects of zolpidem and triazolam on nocturnal sleep and sleep latency in the morning: a cross-over study in healthy young volunteers. ( Akaho, R; Ichikawa, I; Kanno, O; Nakagome, K; Nakajima, T; Sasaki, T; Suzuki, M; Takazawa, S; Watanabe, H, 2000)
"Sixty-five patients, affected by sleep disorders, were entered into the study."	2.67	Quazepam versus triazolam in patients with sleep disorders: a double-blind study. ( Altamura, AC; Gianetti, S; Mauri, MC; Pugnetti, L, 1993)
"In general, chronic insomniacs showed all degrees of daytime alertness regardless of nocturnal sleep parameters."	2.37	Issues in the diagnosis and treatment of insomnia. ( Carskadon, M; Dement, W; Seidel, W, 1984)
"The diagnosis and treatment of insomnia is a major clinical issue."	2.36	Rational basis for the use of sleeping pills. ( Dement, WC, 1983)
"Triazolam was effective in treating the phase delay that reappeared after chronotherapy."	1.28	Daily activity and persistent sleep-wake schedule disorders. ( Iwata, T; Kayukawa, Y; Ohta, T; Okada, T, 1992)
" Possible explanations for the lower frequency of hypnotic use observed in this study as compared to the frequencies reported in the literature are discussed, as are possible hazards of high-dose and long-term use of hypnotics."	1.27	Survey of hypnotic drug use in nursing homes. ( James, DS, 1985)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (52.94)	18.7374
1990's	13 (38.24)	18.2507
2000's	2 (5.88)	29.6817
2010's	1 (2.94)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Obara, Y	1
Tsutsui, R	1
Ishida, T	1
Kamei, C	1
Takahashi, T	1
Okajima, Y	1
Otsubo, T	1
Shinoda, J	1
Mimura, M	1
Nakagome, K	2
Kamijima, K	1
Keighley, MR	1
Gannon, M	1
Warlow, J	1
Jenkins, CR	1
Gammon, RJ	1
Pöldinger, W	2
Sastre-y-Hernández, M	1
Fichte, K	1
Goetzke, E	1
Findeisen, P	1
Welbers, IB	1
Cordingley, GJ	1
Dean, BC	1
Harris, RI	1
Morgan, K	1
Adam, K	2
Oswald, I	2
Shapiro, C	1
Walsh, JK	1
Muehlbach, MJ	1
Schweitzer, PK	1
Dement, WC	2
Dement, W	1
Seidel, W	1
Carskadon, M	1
Seidel, WF	1
Roth, T	1
Roehrs, T	1
Zorick, F	1
Borbély, AA	1
Neuhaus, HU	1
Mattmann, P	1
Waser, PG	1
Rothschild, B	1
Vu, J	1
Mauri, MC	1
Gianetti, S	1
Pugnetti, L	1
Altamura, AC	1
Ando, K	3
Hayakawa, T	3
Ohta, T	4
Kayukawa, Y	4
Ito, A	2
Iwata, T	4
Okada, T	3
Kasahara, Y	2
Terzano, MG	1
Parrino, L	1
Boselli, M	1
Dell'Orso, S	1
Moroni, M	1
Spaggiari, MC	1
Yamadera, H	1
Takahashi, K	1
Okawa, M	1
Sasaki, M	1
DeNucci, DJ	1
Sobiski, C	1
Dionne, RA	1
Kanno, O	1
Sasaki, T	1
Watanabe, H	1
Takazawa, S	1
Nakajima, T	1
Ichikawa, I	1
Akaho, R	1
Suzuki, M	1
Wang, RI	1
Wilbur, M	1
Hieb, E	1
Menkes, DB	1
Bonnet, MH	1
Arand, DL	1
Kogawa, S	1
Terashima, M	1
Gadeholt, G	1
Brørs, O	1
Gray, GE	1
Forgo, I	1
Francescangeli, MA	1
Omicini, A	1
Gentili, P	1
Soldatos, CR	1
Kales, A	1
Bixler, EO	1
Vela-Bueno, A	1
James, DS	1

Article	Year
Rational basis for the use of sleeping pills. Pharmacology, 1983, Volume: 27 Suppl 2 Topics: Anxiety; Chronic Disease; Flurazepam; Humans; Hypnotics and Sedatives; Kinetics; Sleep; Sleep Initia	1983
Issues in the diagnosis and treatment of insomnia. Psychopharmacology. Supplementum, 1984, Volume: 1 Topics: Chronic Disease; Flurazepam; Humans; Hypnotics and Sedatives; Psychomotor Performance; Respiration;	1984
[Jet lag syndrome]. Nihon rinsho. Japanese journal of clinical medicine, 1998, Volume: 56, Issue:2 Topics: Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Phototherapy; Sleep Wake Disorders; Sy	1998
Behavioral side effects of benzodiazepine hypnotics. Clinical neuropharmacology, 1985, Volume: 8 Suppl 1 Topics: Amnesia; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Flurazepam; Humans; Hypnotics and Sedatives;	1985

Article	Year
Comparison of hangover effects among triazolam, flunitrazepam and quazepam in healthy subjects: a preliminary report. Psychiatry and clinical neurosciences, 2003, Volume: 57, Issue:3 Topics: Activities of Daily Living; Adult; Anti-Anxiety Agents; Benzodiazepines; Cross-Over Studies; Fatigue	2003
Evaluation of single-dose hypnotic treatment before elective operation. British medical journal, 1980, Sep-27, Volume: 281, Issue:6244 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female;	1980
Study with lormetazepam as a hypnotic in general practice. Neuropsychobiology, 1983, Volume: 9, Issue:2-3 Topics: Adolescent; Adult; Aged; Ambulatory Care; Anti-Anxiety Agents; Benzodiazepines; Family Practice; Fem	1983
[Triazolam and flunitrazepam in a double-blind cross-over trial]. Therapeutische Umschau. Revue therapeutique, 1983, Volume: 40, Issue:9 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female;	1983
Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam. British journal of clinical pharmacology, 1983, Volume: 16 Suppl 2 Topics: Adult; Aged; Anti-Anxiety Agents; Azepines; Clinical Trials as Topic; Double-Blind Method; Drug Tole	1983
A double-blind comparison of two benzodiazepine hypnotics, flunitrazepam and triazolam, in general practice. Current medical research and opinion, 1984, Volume: 8, Issue:10 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Double-Blind Method; Family Practice; Female; Flunitra	1984
Effect of loprazolam and of triazolam on psychological functions. Psychopharmacology, 1984, Volume: 82, Issue:4 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Female; Humans; Male; Middle Aged; P	1984
Acute administration of triazolam for the daytime sleep of rotating shift workers. Sleep, 1984, Volume: 7, Issue:3 Topics: Adaptation, Physiological; Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method	1984
Treatment of a 12-hour shift of sleep schedule with benzodiazepines. Science (New York, N.Y.), 1984, Jun-15, Volume: 224, Issue:4654 Topics: Adult; Arousal; Benzodiazepines; Emotions; Female; Flurazepam; Humans; Male; Sleep; Sleep Wake Disor	1984
Retrospective assessment of fibromyalgia therapeusis. Comprehensive therapy, 1994, Volume: 20, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Fibromyalgia; Humans; Male; Middle Aged; Retrosp	1994
Quazepam versus triazolam in patients with sleep disorders: a double-blind study. International journal of clinical pharmacology research, 1993, Volume: 13, Issue:3 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Double-Blind Method; Female; Human	1993
Changes of cyclic alternating pattern (CAP) parameters in situational insomnia under brotizolam and triazolam. Psychopharmacology, 1995, Volume: 120, Issue:3 Topics: Adult; Animals; Azepines; Cricetinae; Electroencephalography; Female; Humans; Hypnotics and Sedative	1995
A multicenter study of sleep-wake rhythm disorders: therapeutic effects of vitamin B12, bright light therapy, chronotherapy and hypnotics. Psychiatry and clinical neurosciences, 1996, Volume: 50, Issue:4 Topics: Adolescent; Adult; Chronotherapy; Combined Modality Therapy; Female; Humans; Hypnotics and Sedatives	1996
Triazolam improves sleep but fails to alter pain in TMD patients. Journal of orofacial pain, 1998,Spring, Volume: 12, Issue:2 Topics: Adult; Chronic Disease; Cross-Over Studies; Double-Blind Method; Electromyography; Facial Pain; GABA	1998
Comparison of the effects of zolpidem and triazolam on nocturnal sleep and sleep latency in the morning: a cross-over study in healthy young volunteers. Progress in neuro-psychopharmacology & biological psychiatry, 2000, Volume: 24, Issue:6 Topics: Adult; Affect; Anti-Anxiety Agents; Cross-Over Studies; Humans; Hypnotics and Sedatives; Male; Pyrid	2000
Determining optimum dose and acute tolerance of triazolam. The Journal of international medical research, 1977, Volume: 5, Issue:3 Topics: Adult; Anti-Anxiety Agents; Ataxia; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug	1977
[Treatment of situation-related sleep disorders with midazolam and triazolam--a comparative study of athletes]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1986, Feb-11, Volume: 75, Issue:7 Topics: Adult; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Male	1986
[Double-blind parallel comparison of midazolam and triazolam in sleep disorders in the aged]. La Clinica terapeutica, 1987, Jan-31, Volume: 120, Issue:2 Topics: Age Factors; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Midazolam; M	1987

Article	Year
Effect of ethanol on sleep-awake state in sleep-disturbed rats. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:5 Topics: Animals; Disease Models, Animal; Ethanol; Hypnotics and Sedatives; Male; Rats; Rats, Wistar; Referen	2010
Effects of loprazolam and of triazolam on sleep and overnight urinary cortisol. Psychopharmacology, 1984, Volume: 82, Issue:4 Topics: Aged; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Catecholamines; Drug Tolerance; Femal	1984
[Long term recording of motor activity: its use in research and clinical situations]. Schweizerische medizinische Wochenschrift, 1981, May-23, Volume: 111, Issue:21 Topics: Adult; Aged; Circadian Rhythm; Computers; Female; Humans; Male; Middle Aged; Minicomputers; Motor Ac	1981
Long-term follow-up study of 10 adolescent patients with sleep-wake schedule disorders. The Japanese journal of psychiatry and neurology, 1994, Volume: 48, Issue:1 Topics: Adolescent; Behavior Therapy; Circadian Rhythm; Combined Modality Therapy; Female; Follow-Up Studies	1994
Long-term course of adult patients with delayed sleep phase syndrome. The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:3 Topics: Activities of Daily Living; Adult; Behavior Therapy; Circadian Rhythm; Combined Modality Therapy; Fe	1993
Daily activity and persistent sleep-wake schedule disorders. Progress in neuro-psychopharmacology & biological psychiatry, 1992, Volume: 16, Issue:4 Topics: Adolescent; Adult; Aging; Amides; Body Temperature; Circadian Rhythm; Female; Humans; Hydroxybutyrat	1992
Triazolam-induced nocturnal bingeing with amnesia. The Australian and New Zealand journal of psychiatry, 1992, Volume: 26, Issue:2 Topics: Amnesia; Female; Humans; Hyperphagia; Middle Aged; Obesity; Sleep Initiation and Maintenance Disorde	1992
Chronic use of triazolam in patients with periodic leg movements, fragmented sleep and daytime sleepiness. Aging (Milan, Italy), 1991, Volume: 3, Issue:4 Topics: Aged; Arousal; Female; Humans; Male; Middle Aged; Restless Legs Syndrome; Sleep; Sleep Wake Disorder	1991
Treatment of adolescent patients with sleep-wake schedule disturbances who complain of non-attendance at school. Progress in clinical and biological research, 1990, Volume: 341B Topics: Adolescent; Body Temperature; Circadian Rhythm; Female; Humans; Male; Phototherapy; Sleep; Sleep Wak	1990
[Life with and without Halcion]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1990, Mar-10, Volume: 110, Issue:7 Topics: Dose-Response Relationship, Drug; Drug Industry; Drug Information Services; Humans; Norway; Sleep Wa	1990
MAOI-induced hypersomnia in patients with bulimia. The American journal of psychiatry, 1989, Volume: 146, Issue:8 Topics: Adult; Bulimia; Female; Humans; Phenelzine; Sleep Stages; Sleep Wake Disorders; Triazolam	1989
Survey of hypnotic drug use in nursing homes. Journal of the American Geriatrics Society, 1985, Volume: 33, Issue:6 Topics: Aged; Diphenhydramine; Drug Administration Schedule; Drug Prescriptions; Drug Utilization; Female; F	1985

triazolam and Sleep Wake Disorders

Research Excerpts

Research

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