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triazolam and Seizures

triazolam has been researched along with Seizures in 12 studies

Triazolam: A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"The authors report a case of a 55-year-old man undergoing a triazolam withdrawal syndrome that was recognized and treated with high doses of benzodiazepines, but the patient nevertheless developed seizures."7.67Seizures following triazolam withdrawal despite benzodiazepine treatment. ( Pawluczyk, S; Schneider, LS; Syapin, PJ, 1987)
" Both anticonvulsants tested suppressed seizures in a different manner, however triazolam exerted stronger anticonvulsive activity than the same dose of diazepam did."3.69Convulsive properties of N-(3,5-dimethoxy-4-propoxyphenyl-ethyl) aziridine and their influencing by diazepam and triazolam. ( Herink, J, 1995)
"In this study, we present five cases of seizures following withdrawal of flunitrazepam, lorazepam, or triazolam, representing 3% of a sample consisting of 153 patients dependent on benzodiazepines."3.69Benzodiazepine withdrawal syndrome seizures. ( de Iceta, M; Martínez-Cano, H; Martínez-Gras, I; Pomalima, R; Vela-Bueno, A, 1995)
" The four BZR ligands triazolam, diazepam, Ro 19-8022 (a benzoquinolizinone) and bretazenil (Ro 16-6028, an imidazobenzodiazepinone) were pharmacologically characterized in various neurological and behavioral paradigms in mice: two anticonvulsant tests (prevention of audiogenic and pentylenetetrazol-induced seizures), a conflict test which reveals both anxiolytic and sedative properties and two tests which mainly measure motor impairment (rotarod and horizontal wire test)."3.68Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies. ( Bonetti, EP; Facklam, M; Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Schoch, P, 1992)
"The authors report a case of a 55-year-old man undergoing a triazolam withdrawal syndrome that was recognized and treated with high doses of benzodiazepines, but the patient nevertheless developed seizures."3.67Seizures following triazolam withdrawal despite benzodiazepine treatment. ( Pawluczyk, S; Schneider, LS; Syapin, PJ, 1987)
" for 14 days) the corresponding dose-response lines were shifted to the right suggesting tolerance development."1.27Subacute benzodiazepine treatment: observations on behavioural tolerance and withdrawal. ( Gonzalez, JP; McCulloch, AJ; Nicholls, PJ; Sewell, RD; Tekle, A, 1984)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19907 (58.33)18.7374
1990's5 (41.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gall, M1
Lahti, RA1
Rudzik, AD1
Duchamp, DJ1
Chidester, C1
Scahill, T1
Gonzalez, JP1
McCulloch, AJ1
Nicholls, PJ1
Sewell, RD1
Tekle, A1
Herink, J2
Martínez-Cano, H1
Vela-Bueno, A1
de Iceta, M1
Pomalima, R1
Martínez-Gras, I1
Facklam, M1
Schoch, P1
Bonetti, EP1
Jenck, F1
Martin, JR1
Moreau, JL1
Haefely, WE1
Koupilová, M1
Bajgar, J1
Piot, O1
Betschart, J1
Stutzmann, JM1
Blanchard, JC1
Griffith, JL1
Schneider, LS1
Syapin, PJ1
Pawluczyk, S1
Laplane, D1
Baulac, M1
Lacomblez, L1
Patterson, WM1
Tien, AY1
Gujavarty, KS1

Other Studies

12 other studies available for triazolam and Seizures

ArticleYear
Novel anxiolytic agents derived from alpha-amino-alpha-phenyl-o-tolyl-4H-triazoles and -imidazoles.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Crystallography; Hypnotics and Sedatives; Imid

1978
Subacute benzodiazepine treatment: observations on behavioural tolerance and withdrawal.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1984, Volume: 19, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Psychological; Diazepam; Drinking Beha

1984
Convulsive properties of N-(3,5-dimethoxy-4-propoxyphenyl-ethyl) aziridine and their influencing by diazepam and triazolam.
    Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove, 1995, Volume: 38, Issue:2

    Topics: Animals; Anticonvulsants; Aziridines; Diazepam; Male; Rats; Rats, Wistar; Seizures; Triazolam

1995
Benzodiazepine withdrawal syndrome seizures.
    Pharmacopsychiatry, 1995, Volume: 28, Issue:6

    Topics: Adult; Anti-Anxiety Agents; Female; Flunitrazepam; Heroin Dependence; Humans; Hypnotics and Sedative

1995
Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Administration, Oral; Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Female

1992
Effect of triazolam in convulsions induced by pentylenetetrazol.
    Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems, 1991, Volume: 33, Issue:4

    Topics: Animals; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Triazolam

1991
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
    Neuroscience letters, 1990, Sep-04, Volume: 117, Issue:1-2

    Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze

1990
Treatment of episodic behavioral disorders with rapidly absorbed benzodiazepines.
    The Journal of nervous and mental disease, 1985, Volume: 173, Issue:5

    Topics: Administration, Oral; Adult; Aggression; Anger; Anti-Anxiety Agents; Clorazepate Dipotassium; Diazep

1985
Seizures following triazolam withdrawal despite benzodiazepine treatment.
    The Journal of clinical psychiatry, 1987, Volume: 48, Issue:10

    Topics: Anti-Anxiety Agents; Anxiety Disorders; Chlordiazepoxide; Diazepam; Humans; Male; Middle Aged; Recep

1987
[Convulsions 12 hours after the ingestion of benzodiazepine with a short half-life].
    Presse medicale (Paris, France : 1983), 1988, Mar-12, Volume: 17, Issue:9

    Topics: Adult; Female; Half-Life; Humans; Recurrence; Seizures; Time Factors; Triazolam

1988
Triazolam withdrawal.
    The Journal of clinical psychiatry, 1988, Volume: 49, Issue:9

    Topics: Alprazolam; Diazepam; Drug Tolerance; Humans; Seizures; Substance Withdrawal Syndrome; Triazolam

1988
Seizure following withdrawal from triazolam.
    The American journal of psychiatry, 1985, Volume: 142, Issue:12

    Topics: Adult; Female; Humans; Seizures; Substance Withdrawal Syndrome; Triazolam

1985