triazolam has been researched along with Aging in 15 studies
Triazolam: A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aging alters many aspects of circadian rhythmicity, including responsivity to phase-shifting stimuli and the amplitude of the rhythm of melatonin secretion." | 3.71 | Feeding melatonin enhances the phase shifting response to triazolam in both young and old golden hamsters. ( Bennett, KM; Dutton-Boilek, J; Horton, TH; Kolker, DE; Losee Olson, S; Turek, FW; Wallen, EP, 2002) |
| " Among women, age had no significant effect on area under the triazolam plasma concentration curve (AUC) (Spearman r=0." | 2.71 | Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate. ( Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL; Wright, CE, 2004) |
| " There were no changes in the half-life of triazolam or alpha-hydroxytriazolam." | 2.70 | Effect of ranitidine on the pharmacokinetics of triazolam and alpha-hydroxytriazolam in both young (19-60 years) and older (61-78 years) people. ( Kersey, K; Koch, KM; Lam, R; O'Connor-Semmes, RL; Williams, DH, 2001) |
| "Triazolam was effective in treating the phase delay that reappeared after chronotherapy." | 1.28 | Daily activity and persistent sleep-wake schedule disorders. ( Iwata, T; Kayukawa, Y; Ohta, T; Okada, T, 1992) |
| " Mean triazolam elimination half-life was not significantly different between young and elderly men (3." | 1.27 | Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity. ( Abernethy, DR; Divoll, M; Greenblatt, DJ; Moschitto, LJ; Shader, RI; Smith, RB, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 9 (60.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Patki, KC | 1 |
| von Moltke, LL | 3 |
| Harmatz, JS | 2 |
| Hesse, LM | 1 |
| Court, MH | 1 |
| Greenblatt, DJ | 4 |
| Warrington, JS | 1 |
| Wright, CE | 1 |
| Shader, RI | 2 |
| Divoll, M | 1 |
| Abernethy, DR | 1 |
| Moschitto, LJ | 1 |
| Smith, RB | 1 |
| Mrosovsky, N | 1 |
| Biello, SM | 1 |
| Penev, PD | 1 |
| Zee, PC | 2 |
| Turek, FW | 4 |
| Van Reeth, O | 3 |
| Zhang, Y | 2 |
| Reddy, A | 1 |
| Zee, P | 1 |
| Robin, DW | 1 |
| Hasan, SS | 1 |
| Edeki, T | 1 |
| Lichtenstein, MJ | 1 |
| Shiavi, RG | 1 |
| Wood, AJ | 1 |
| O'Connor-Semmes, RL | 1 |
| Kersey, K | 1 |
| Williams, DH | 1 |
| Lam, R | 1 |
| Koch, KM | 1 |
| Kolker, DE | 1 |
| Losee Olson, S | 1 |
| Dutton-Boilek, J | 1 |
| Bennett, KM | 1 |
| Wallen, EP | 1 |
| Horton, TH | 1 |
| Ohta, T | 1 |
| Iwata, T | 1 |
| Kayukawa, Y | 1 |
| Okada, T | 1 |
| Nikaido, AM | 1 |
| Ellinwood, EH | 1 |
| Heatherly, DG | 1 |
| Gupta, SK | 1 |
| Fisch, HU | 1 |
| Baktir, G | 1 |
| Karlaganis, G | 1 |
| Minder, C | 1 |
| Bircher, J | 1 |
4 trials available for triazolam and Aging
| Article | Year |
|---|---|
Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate.
Topics: Adult; Aged; Aging; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome | 2004 |
Increased baseline sway contributes to increased losses of balance in older people following triazolam.
Topics: Adult; Age Factors; Aged; Aging; Double-Blind Method; Drug Monitoring; Humans; Hypnotics and Sedativ | 1996 |
Effect of ranitidine on the pharmacokinetics of triazolam and alpha-hydroxytriazolam in both young (19-60 years) and older (61-78 years) people.
Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Anti-Ulcer Agents; Area Under Curve; | 2001 |
Age-related increase in CNS sensitivity to benzodiazepines as assessed by task difficulty.
Topics: Adult; Aged; Aging; Alprazolam; Anti-Anxiety Agents; Brain; Dose-Response Relationship, Drug; Female | 1990 |
11 other studies available for triazolam and Aging
| Article | Year |
|---|---|
Effect of age on in vitro triazolam biotransformation in male human liver microsomes.
Topics: Aging; Biotransformation; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; | 2004 |
Age-related differences in CYP3A expression and activity in the rat liver, intestine, and kidney.
Topics: Age Factors; Aging; Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrom | 2004 |
Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity.
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Antipyrine; Female; Half-Life; Humans; Kinetics; Liver; Mal | 1983 |
Nonphotic phase shifting in the old and the cold.
Topics: Aging; Animals; Arousal; Circadian Rhythm; Cold Temperature; Cricetinae; Estrus; Female; Male; Mesoc | 1994 |
Monoamine depletion blocks triazolam-induced phase advances of the circadian clock in hamsters.
Topics: Aging; Animals; Arousal; Biogenic Monoamines; Brain Chemistry; Circadian Rhythm; Cricetinae; Male; M | 1994 |
Aging alters the entraining effects of an activity-inducing stimulus on the circadian clock.
Topics: Aging; Animals; Arousal; Blindness; Circadian Rhythm; Cricetinae; Eye Enucleation; Mesocricetus; Mot | 1993 |
Feeding melatonin enhances the phase shifting response to triazolam in both young and old golden hamsters.
Topics: Administration, Oral; Aging; Animals; Circadian Rhythm; Cricetinae; Drug Synergism; In Vitro Techniq | 2002 |
Aging alters feedback effects of the activity-rest cycle on the circadian clock.
Topics: Activity Cycles; Aging; Analysis of Variance; Animals; Circadian Rhythm; Cricetinae; Feedback; Mesoc | 1992 |
Aging alters the feedback effects of the activity-rest cycle on the hamster's circadian clock.
Topics: Activity Cycles; Aging; Animals; Circadian Rhythm; Cricetinae; Feedback; Mesocricetus; Triazolam | 1992 |
Daily activity and persistent sleep-wake schedule disorders.
Topics: Adolescent; Adult; Aging; Amides; Body Temperature; Circadian Rhythm; Female; Humans; Hydroxybutyrat | 1992 |
Excessive motor impairment two hours after triazolam in the elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Male; Middle Aged; Psychomotor Performance; T | 1990 |