triamterene has been researched along with Glomerulosclerosis, Focal Segmental in 1 studies
Triamterene: A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
triamterene : Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.
Glomerulosclerosis, Focal Segmental: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amiloride has a significant role in the reduction of podocyte cell motility in vitro and proteinuria in mice." | 5.38 | Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria. ( Shi, W; Xie, S; Yang, Y; Zhang, B, 2012) |
| "Amiloride has a significant role in the reduction of podocyte cell motility in vitro and proteinuria in mice." | 1.38 | Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria. ( Shi, W; Xie, S; Yang, Y; Zhang, B, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, B | 1 |
| Xie, S | 1 |
| Shi, W | 1 |
| Yang, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Crossover Pilot Study of the Effect of Amiloride on Proteinuria in Patients With Proteinuric Kidney Disease[NCT02522650] | Phase 4 | 30 participants (Anticipated) | Interventional | 2013-07-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for triamterene and Glomerulosclerosis, Focal Segmental
| Article | Year |
|---|---|
Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria.
Topics: Amiloride; Animals; Cell Movement; Cells, Cultured; Disease Models, Animal; Epithelial Sodium Channe | 2012 |