triamterene has been researched along with Disease Models, Animal in 7 studies
Triamterene: A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
triamterene : Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amiloride has a significant role in the reduction of podocyte cell motility in vitro and proteinuria in mice." | 5.38 | Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria. ( Shi, W; Xie, S; Yang, Y; Zhang, B, 2012) |
| " This study was conducted to investigate whether or not triamterene, a K(+)-sparing diuretic, can generate protection against seizures induced by intravenous or intraperitoneal pentylenetetrazole (PTZ) models." | 3.83 | A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice. ( Almasirad, A; Barati, S; Ghasemi, M; Moezi, L; Shafaroodi, H, 2016) |
| " After sporozoite inoculation and blood-stage cure of initial parasitemia with chloroquine, rhesus macaques were treated on subsequent relapses with chloroquine in conjunction with test regimens of approved drugs." | 3.78 | Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances. ( Bennett, K; Deye, GA; Fracisco, S; Gettayacamin, M; Hansukjariya, P; Im-erbsin, R; Macareo, L; Magill, AJ; Ohrt, C; Rothstein, Y; Sattabongkot, J, 2012) |
| " We also tested chlorthiazide and furosemide for seizure protection in animal models of epilepsy." | 3.71 | Are certain diuretics also anticonvulsants? ( Annegers, JF; Cascino, G; Hauser, WA; Hesdorffer, DC; Stables, JP, 2001) |
| "Amiloride has a significant role in the reduction of podocyte cell motility in vitro and proteinuria in mice." | 1.38 | Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria. ( Shi, W; Xie, S; Yang, Y; Zhang, B, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Shafaroodi, H | 1 |
| Barati, S | 1 |
| Ghasemi, M | 1 |
| Almasirad, A | 1 |
| Moezi, L | 1 |
| Zhang, B | 1 |
| Xie, S | 1 |
| Shi, W | 1 |
| Yang, Y | 1 |
| Deye, GA | 1 |
| Gettayacamin, M | 1 |
| Hansukjariya, P | 1 |
| Im-erbsin, R | 1 |
| Sattabongkot, J | 1 |
| Rothstein, Y | 1 |
| Macareo, L | 1 |
| Fracisco, S | 1 |
| Bennett, K | 1 |
| Magill, AJ | 1 |
| Ohrt, C | 1 |
| Entrikin, RK | 1 |
| Patterson, GT | 1 |
| Wilson, BW | 1 |
| Hesdorffer, DC | 1 |
| Stables, JP | 1 |
| Hauser, WA | 1 |
| Annegers, JF | 1 |
| Cascino, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Crossover Pilot Study of the Effect of Amiloride on Proteinuria in Patients With Proteinuric Kidney Disease[NCT02522650] | Phase 4 | 30 participants (Anticipated) | Interventional | 2013-07-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for triamterene and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Diazoxide; Disease Models, Animal; Dose | 2016 |
Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria.
Topics: Amiloride; Animals; Cell Movement; Cells, Cultured; Disease Models, Animal; Epithelial Sodium Channe | 2012 |
Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclinical; Macaca mu | 2012 |
Drug evaluation in muscular dystrophy of the chicken.
Topics: Animals; Body Weight; Chickens; Corticosterone; Disease Models, Animal; Dose-Response Relationship, | 1982 |
Are certain diuretics also anticonvulsants?
Topics: Aged; Animals; Case-Control Studies; Disease Models, Animal; Diuretics; Dose-Response Relationship, | 2001 |