triamterene has been researched along with Arrhythmias, Cardiac in 14 studies
Triamterene: A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
triamterene : Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years." | 7.64 | CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964) |
| "In the majority of hypertensive patients, treatment with 50 mg/d of hydrochlorothiazide does not cause marked hypokalemia or ventricular arrhythmias." | 5.07 | Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. ( Black, DM; Cheitlin, MD; Fine, R; Hearst, N; Hulley, SB; Sebastian, A; Seeley, DG; Siegel, D, 1992) |
| "Nineteen men with mild to moderate hypertension and without a history of cardiac arrhythmias were randomized (double-blind) into groups to receive hydrochlorothiazide (HCTZ) at a dose of 25 mg/day, HCTZ at 50 mg/day, or HCTZ (25 mg) plus triamterene (50 mg) for a six-month period after a three-week (single-blind) placebo period." | 5.06 | Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension. ( Hamilton, BP; Hamilton, J; Peters, RW, 1989) |
| "The antiarrhythmic effects of 4 pteridine analogues, 2 of which are potassium-sparing diuretics, triamterene (2, 4, 7-triamino-6-phenylpteridine) and [2-phenyl-4, 7 diaminopteridine-6-(N-diethylaminoethyl) carboxamide] and 2 of which have no diuretic effects [2-phenyl-4, 7-diaminopteridine-6-(N-2-hydroxyethyl) carboxamide], on ouabain-induced ventricular tachycardia in intact pentobarbital-anesthetized dogs were investigated." | 3.65 | Antiarrhythmic activity of four pteridine compounds in ouabain intoxication. ( Elias, RA; Francis, JS; Gosselin, AJ; Yeh, BK, 1975) |
| " toxicity of digoxin is diminished by pretreatment with triamterene or amiloride; the arrhythmias and the cardiac arrest are significantly delayed in the course of an infusion of digoxin." | 3.65 | [Animal experiments on the effect of triamterene and amiloride on heart and circulation and the toxicity of digoxin (author's transl)]. ( Greeff, K; Köhler, E, 1975) |
| "Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years." | 3.64 | CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964) |
| "Pretreatment with triamterene (5 mg/kg and 10 mg/kg) significantly reduces the ouabain toxicity indicated by an increase of the dose producing arrhythmia (from 61 +/- 14 to 121 +/- 17 and 178 +/- 22 micrograms/kg, resp." | 1.27 | [The antitoxic action of triamterene in cardiac glycoside poisoning]. ( Güttler, K; Jenke, J; Klaus, W, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (92.86) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LAUFER, ST | 2 |
| MAHABIR, RN | 2 |
| Papademetriou, V | 1 |
| Fletcher, R | 1 |
| Khatri, IM | 1 |
| Freis, ED | 1 |
| Erdmann, E | 1 |
| Krawietz, W | 1 |
| Poppert, D | 1 |
| Krüger, R | 1 |
| von Arnim, T | 1 |
| Vogt, W | 1 |
| Bolte, HD | 1 |
| Yeh, BK | 1 |
| Francis, JS | 1 |
| Gosselin, AJ | 1 |
| Elias, RA | 1 |
| Tilser, I | 1 |
| Segre, G | 1 |
| Seller, RH | 1 |
| Greco, J | 1 |
| Banach, S | 1 |
| Seth, R | 1 |
| Greeff, K | 1 |
| Köhler, E | 1 |
| Siegel, D | 1 |
| Hulley, SB | 1 |
| Black, DM | 1 |
| Cheitlin, MD | 1 |
| Sebastian, A | 1 |
| Seeley, DG | 1 |
| Hearst, N | 1 |
| Fine, R | 1 |
| Peters, RW | 1 |
| Hamilton, J | 1 |
| Hamilton, BP | 1 |
| Güttler, K | 1 |
| Jenke, J | 1 |
| Klaus, W | 1 |
| Reidenberg, MM | 1 |
| Affrime, M | 1 |
| Leemhuis, MP | 1 |
| Struyvenberg, A | 1 |
| Bruun, L | 1 |
| Czartoryski, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000525] | Phase 3 | 233 participants (Actual) | Interventional | 1986-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for triamterene and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Significance of hypokalaemia due to diuretics.
Topics: Amiloride; Arrhythmias, Cardiac; Chlorothiazide; Diuretics; Ethacrynic Acid; Extracellular Space; Fu | 1973 |
3 trials available for triamterene and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Chlorthalidone; Double-Blind Method; Electrocardi | 1992 |
Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension.
Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Drug Administratio | 1989 |
[Triamterene in acute myocardial infarction. Prospective double-blind study of the effect of triamterene on the frequency of arrhythmia and mortality in acute myocardial infarction].
Topics: Acute Disease; Aged; Arrhythmias, Cardiac; Biological Transport; Cell Membrane; Clinical Trials as T | 1974 |
10 other studies available for triamterene and Arrhythmias, Cardiac
| Article | Year |
|---|---|
CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE.
Topics: Arrhythmias, Cardiac; Canada; Chlorides; Digitalis Glycosides; Diuretics; Edema; Heart Failure; Hydr | 1964 |
Diuretic-induced hypokalemia in uncomplicated systemic hypertension: effect of plasma potassium correction on cardiac arrhythmias.
Topics: Adult; Aged; Ambulatory Care; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiac Complexes, Prem | 1983 |
[Cardiac effects of antikaliuretic diuretics-clinical and biochemical investigation (author's transl)].
Topics: Adenosine Triphosphatases; Adult; Aged; Arrhythmias, Cardiac; Canrenoic Acid; Cardiac Output; Cell M | 1977 |
Antiarrhythmic activity of four pteridine compounds in ouabain intoxication.
Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Node; Depression, Chemical; Dogs; Electrocardiograph | 1975 |
The effect of clonidine, triamterene, and amiloride on pharmacokinetics and cardiotoxicity of ouabain in rabbits.
Topics: Amiloride; Animals; Arrhythmias, Cardiac; Clonidine; Electrocardiography; Heart Rate; Kinetics; Male | 1978 |
Increasing the inotropic effect and toxic dose of digitalis by the administration of antikaliuretic drugs--further evidence for a cardiac effect of diuretic agents.
Topics: Amiloride; Animals; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Heart; Myocardial | 1975 |
[Animal experiments on the effect of triamterene and amiloride on heart and circulation and the toxicity of digoxin (author's transl)].
Topics: Amiloride; Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Digoxin; Drug Evaluation, Preclinica | 1975 |
[The antitoxic action of triamterene in cardiac glycoside poisoning].
Topics: Animals; Arrhythmias, Cardiac; Cardiac Glycosides; Digitoxin; Electrocardiography; Potassium; Rabbit | 1986 |
Influence of disease on binding of drugs to plasma proteins.
Topics: Arrhythmias, Cardiac; Arteriosclerosis; Blood Proteins; Blood Urea Nitrogen; Carbon Radioisotopes; C | 1973 |
Clinical evaluation of diuretics in congestive heart failure. A detailed study in four patients.
Topics: Aged; Arrhythmias, Cardiac; Chlorides; Diuretics; Drug Synergism; Furosemide; Heart Failure; Humans; | 1969 |