triamterene has been researched along with Arrhythmia in 14 studies
Triamterene: A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
triamterene : Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years." | 7.64 | CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964) |
| "In the majority of hypertensive patients, treatment with 50 mg/d of hydrochlorothiazide does not cause marked hypokalemia or ventricular arrhythmias." | 5.07 | Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. ( Black, DM; Cheitlin, MD; Fine, R; Hearst, N; Hulley, SB; Sebastian, A; Seeley, DG; Siegel, D, 1992) |
| "Nineteen men with mild to moderate hypertension and without a history of cardiac arrhythmias were randomized (double-blind) into groups to receive hydrochlorothiazide (HCTZ) at a dose of 25 mg/day, HCTZ at 50 mg/day, or HCTZ (25 mg) plus triamterene (50 mg) for a six-month period after a three-week (single-blind) placebo period." | 5.06 | Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension. ( Hamilton, BP; Hamilton, J; Peters, RW, 1989) |
| "The antiarrhythmic effects of 4 pteridine analogues, 2 of which are potassium-sparing diuretics, triamterene (2, 4, 7-triamino-6-phenylpteridine) and [2-phenyl-4, 7 diaminopteridine-6-(N-diethylaminoethyl) carboxamide] and 2 of which have no diuretic effects [2-phenyl-4, 7-diaminopteridine-6-(N-2-hydroxyethyl) carboxamide], on ouabain-induced ventricular tachycardia in intact pentobarbital-anesthetized dogs were investigated." | 3.65 | Antiarrhythmic activity of four pteridine compounds in ouabain intoxication. ( Elias, RA; Francis, JS; Gosselin, AJ; Yeh, BK, 1975) |
| " toxicity of digoxin is diminished by pretreatment with triamterene or amiloride; the arrhythmias and the cardiac arrest are significantly delayed in the course of an infusion of digoxin." | 3.65 | [Animal experiments on the effect of triamterene and amiloride on heart and circulation and the toxicity of digoxin (author's transl)]. ( Greeff, K; Köhler, E, 1975) |
| "Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years." | 3.64 | CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964) |
| "Pretreatment with triamterene (5 mg/kg and 10 mg/kg) significantly reduces the ouabain toxicity indicated by an increase of the dose producing arrhythmia (from 61 +/- 14 to 121 +/- 17 and 178 +/- 22 micrograms/kg, resp." | 1.27 | [The antitoxic action of triamterene in cardiac glycoside poisoning]. ( Güttler, K; Jenke, J; Klaus, W, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (92.86) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LAUFER, ST | 2 |
| MAHABIR, RN | 2 |
| Papademetriou, V | 1 |
| Fletcher, R | 1 |
| Khatri, IM | 1 |
| Freis, ED | 1 |
| Erdmann, E | 1 |
| Krawietz, W | 1 |
| Poppert, D | 1 |
| Krüger, R | 1 |
| von Arnim, T | 1 |
| Vogt, W | 1 |
| Bolte, HD | 1 |
| Yeh, BK | 1 |
| Francis, JS | 1 |
| Gosselin, AJ | 1 |
| Elias, RA | 1 |
| Tilser, I | 1 |
| Segre, G | 1 |
| Seller, RH | 1 |
| Greco, J | 1 |
| Banach, S | 1 |
| Seth, R | 1 |
| Greeff, K | 1 |
| Köhler, E | 1 |
| Siegel, D | 1 |
| Hulley, SB | 1 |
| Black, DM | 1 |
| Cheitlin, MD | 1 |
| Sebastian, A | 1 |
| Seeley, DG | 1 |
| Hearst, N | 1 |
| Fine, R | 1 |
| Peters, RW | 1 |
| Hamilton, J | 1 |
| Hamilton, BP | 1 |
| Güttler, K | 1 |
| Jenke, J | 1 |
| Klaus, W | 1 |
| Reidenberg, MM | 1 |
| Affrime, M | 1 |
| Leemhuis, MP | 1 |
| Struyvenberg, A | 1 |
| Bruun, L | 1 |
| Czartoryski, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000525] | Phase 3 | 233 participants (Actual) | Interventional | 1986-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for triamterene and Arrhythmia
| Article | Year |
|---|---|
Significance of hypokalaemia due to diuretics.
Topics: Amiloride; Arrhythmias, Cardiac; Chlorothiazide; Diuretics; Ethacrynic Acid; Extracellular Space; Fu | 1973 |
3 trials available for triamterene and Arrhythmia
| Article | Year |
|---|---|
Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Chlorthalidone; Double-Blind Method; Electrocardi | 1992 |
Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension.
Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Drug Administratio | 1989 |
[Triamterene in acute myocardial infarction. Prospective double-blind study of the effect of triamterene on the frequency of arrhythmia and mortality in acute myocardial infarction].
Topics: Acute Disease; Aged; Arrhythmias, Cardiac; Biological Transport; Cell Membrane; Clinical Trials as T | 1974 |
10 other studies available for triamterene and Arrhythmia
| Article | Year |
|---|---|
CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE.
Topics: Arrhythmias, Cardiac; Canada; Chlorides; Digitalis Glycosides; Diuretics; Edema; Heart Failure; Hydr | 1964 |
Diuretic-induced hypokalemia in uncomplicated systemic hypertension: effect of plasma potassium correction on cardiac arrhythmias.
Topics: Adult; Aged; Ambulatory Care; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiac Complexes, Prem | 1983 |
[Cardiac effects of antikaliuretic diuretics-clinical and biochemical investigation (author's transl)].
Topics: Adenosine Triphosphatases; Adult; Aged; Arrhythmias, Cardiac; Canrenoic Acid; Cardiac Output; Cell M | 1977 |
Antiarrhythmic activity of four pteridine compounds in ouabain intoxication.
Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Node; Depression, Chemical; Dogs; Electrocardiograph | 1975 |
The effect of clonidine, triamterene, and amiloride on pharmacokinetics and cardiotoxicity of ouabain in rabbits.
Topics: Amiloride; Animals; Arrhythmias, Cardiac; Clonidine; Electrocardiography; Heart Rate; Kinetics; Male | 1978 |
Increasing the inotropic effect and toxic dose of digitalis by the administration of antikaliuretic drugs--further evidence for a cardiac effect of diuretic agents.
Topics: Amiloride; Animals; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Heart; Myocardial | 1975 |
[Animal experiments on the effect of triamterene and amiloride on heart and circulation and the toxicity of digoxin (author's transl)].
Topics: Amiloride; Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Digoxin; Drug Evaluation, Preclinica | 1975 |
[The antitoxic action of triamterene in cardiac glycoside poisoning].
Topics: Animals; Arrhythmias, Cardiac; Cardiac Glycosides; Digitoxin; Electrocardiography; Potassium; Rabbit | 1986 |
Influence of disease on binding of drugs to plasma proteins.
Topics: Arrhythmias, Cardiac; Arteriosclerosis; Blood Proteins; Blood Urea Nitrogen; Carbon Radioisotopes; C | 1973 |
Clinical evaluation of diuretics in congestive heart failure. A detailed study in four patients.
Topics: Aged; Arrhythmias, Cardiac; Chlorides; Diuretics; Drug Synergism; Furosemide; Heart Failure; Humans; | 1969 |