tretinoin and Vulvar-Neoplasms

Topics: Adult; Antineoplastic Agents; Carcinoma in Situ; Combined Modality Therapy; Female; HIV Infections; Humans; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Tretinoin; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Vaginal Neoplasms; Vulvar Neoplasms

A group of 35 patients with leukoplakia of the vulva was treated with 13-cis retinoic acid applied topically. Complete or partial remission occurred in 17 patients. Parallel determination of retinol level in sera revealed its increased value as compared to healthy persons.

Topics: Administration, Topical; Adult; Aged; Drug Evaluation; Female; Humans; Leukoplakia; Middle Aged; Tretinoin; Vulvar Neoplasms

Repeated topical application of 13-cis-retinoic acid resulted in complete disappearance of leukoplakia of the vulva in 8 out of 16 patients, among them 2 out of 3 with recurrence after vulvectomy. A considerable regression of leukoplakia was seen in 7 other patients, usually after 1 to 2 months of daily retinoid treatment. After 2-4 months of maintenance therapy and during 3-7 months of the follow up period no recurrences were seen. Side effects of treatment could be managed. Serum retinol level was found to be lower in patients then in healthy subjects. The results suggest that patients with chronic epithelial vulvar dystrophies could benefit from local retinoid treatment, especially in cases with advanced dystrophies until now qualified for vulvectomy.

Topics: Administration, Topical; Adult; Antineoplastic Agents; Female; Humans; Isotretinoin; Leukoplakia; Middle Aged; Tretinoin; Vulvar Neoplasms

Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Clone Cells; Female; Fibrinolysis; Fibrosarcoma; HeLa Cells; Humans; Melanoma; Mice; Neoplasms; Osteosarcoma; Plasminogen Activators; Tretinoin; Vulvar Neoplasms

Topics: Adult; Bowen's Disease; Carcinoma, Squamous Cell; Etretinate; Female; Humans; Skin Neoplasms; Tretinoin; Vulvar Neoplasms