tretinoin and Vitreous-Hemorrhage

The syndrome of vitreous hemorrhage in association with any form of intracranial bleeding is known as Terson's syndrome. Acute promyelocytic leukemia (APL) constitutes 5% to 15% of cases of acute nonlymphocytic leukemias, in which hemorrhagic diathesis often occurs and results in a rapid fatal outcome. In this report we describe a patient with APL who developed cerebral bleeding in association with bilateral subhyaloid and vitreous hemorrhages consistent with Terson's syndrome while she was on all-trans retinoic acid induction therapy.

Topics: Adult; Cerebral Hemorrhage; Female; Fundus Oculi; Humans; Leukemia, Promyelocytic, Acute; Syndrome; Tomography, X-Ray Computed; Tretinoin; Vitreous Hemorrhage