tretinoin has been researched along with Ureteral-Diseases* in 1 studies
1 other study(ies) available for tretinoin and Ureteral-Diseases
| Article | Year |
|---|---|
Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme.
The establishment of the peristaltic machinery of the ureter is precisely controlled to cope with the onset of urine production in the fetal kidney. Retinoic acid (RA) has been identified as a signal that maintains the mesenchymal progenitors of the contractile smooth muscle cells (SMCs), while WNTs, SHH, and BMP4 induce their differentiation. How the activity of the underlying signalling pathways is controlled in time, space, and quantity to activate coordinately the SMC programme is poorly understood. Here, we provide evidence that the Zn-finger transcription factor GATA2 is involved in this crosstalk. In mice, Gata2 is expressed in the undifferentiated ureteric mesenchyme under control of RA signalling. Conditional deletion of Gata2 by a Tbx18 Topics: Animals; Biomarkers; Cell Differentiation; Female; GATA2 Transcription Factor; Male; Mesoderm; Mice; Myocytes, Smooth Muscle; Signal Transduction; Tretinoin; Ureter; Ureteral Diseases | 2019 |