tretinoin and Pancreatic-Diseases

tretinoin has been researched along with Pancreatic-Diseases* in 1 studies

Other Studies

1 other study(ies) available for tretinoin and Pancreatic-Diseases

Article	Year
Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Proceedings of the National Academy of Sciences of the United States of America, 1998, Jul-21, Volume: 95, Issue:15 Expression of peroxisome proliferator-activated receptor alpha (PPARalpha) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARalpha/retinoid x receptor ligands, and FA all up-regulate PPARalpha and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPARalpha is a OB-R-dependent factor required for normal fat homeostasis in islet cells. Topics: Animals; Base Sequence; Clofibrate; DNA Primers; Gene Expression Regulation; Islets of Langerhans; Leptin; Male; Pancreatic Diseases; Proteins; Rats; Rats, Mutant Strains; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Tretinoin	1998

Article

Year

Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.

Proceedings of the National Academy of Sciences of the United States of America, 1998, Jul-21, Volume: 95, Issue:15

Expression of peroxisome proliferator-activated receptor alpha (PPARalpha) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARalpha/retinoid x receptor ligands, and FA all up-regulate PPARalpha and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPARalpha is a OB-R-dependent factor required for normal fat homeostasis in islet cells.

Topics: Animals; Base Sequence; Clofibrate; DNA Primers; Gene Expression Regulation; Islets of Langerhans; Leptin; Male; Pancreatic Diseases; Proteins; Rats; Rats, Mutant Strains; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Tretinoin

1998