tretinoin and Oral-Ulcer

tretinoin has been researched along with Oral-Ulcer* in 1 studies

Other Studies

1 other study(ies) available for tretinoin and Oral-Ulcer

ArticleYear
Lingual ulceration associated with retinoic acid syndrome during treatment of acute promyelocytic leukemia.
    International journal of dermatology, 2014, Volume: 53, Issue:7

    All-trans retinoic acid (ATRA) is routinely associated with chemotherapy for the treatment of acute promyelocytic leukemia (APL). Several reports of scrotal ulceration induced by this agent have been made in the recent years.. The aim of this article was to report the first case of a lingual ulceration associated with retinoic acid syndrome (RAS).. We presented a 32-year-old man with a diagnosis of acute promyelocytic leukemia who received treatment with ATRA. He presented with febrile neutropenia and a lingual ulcer that did not respond to antibiotic and antifungal regimens. He developed weight gain, lower limb edema, polyserositis, and acute renal failure. Retinoic acid syndrome syndrome was diagnosed.. An exhaustive attempt to exclude infectious causes was made performing repeated cultures, histologic examinations, and direct immunofluorescence for HSV. No causative agent was identified. Re-epithelialization of the ulcer was achieved with ATRA cessation and treatment with systemic steroids.. As far as we are concerned, we report the first case of a lingual ulceration associated with RAS.. It is important for dermatologists to recognize this cutaneous complication of ATRA as it poses many differential diagnoses in neutropenic patients.

    Topics: Acute Kidney Injury; Adult; Antineoplastic Combined Chemotherapy Protocols; Febrile Neutropenia; Humans; Idarubicin; Leukemia, Promyelocytic, Acute; Male; Oral Ulcer; Syndrome; Tongue Diseases; Tretinoin

2014