tretinoin and Obsessive-Compulsive-Disorder

The psychosocial aspects of the treatment of photodamaged skin have received little attention.. We prospectively examined the psychosocial correlates of the treatment of mildly to severely photodamaged skin.. Sixty subjects (age, 53.3 +/- 1.3 years [mean +/- standard error]; 35 receiving retinoic acid and 25 the inactive vehicle) completed a battery of psychosocial ratings before starting therapy and after 24 weeks of therapy with retinoic acid or vehicle.. Before therapy, the subjects had pathologically high obsessive-compulsiveness scores (measured by the Brief Symptom Inventory [BSI]). From before to after therapy, the retinoic acid group reported decreased obsessive-compulsiveness (BSI) (p = 0.01), and decreased phobic anxiety (BSI) (p = 0.04), whereas the vehicle group reported an increase (p < 0.05) in both these symptom dimensions.. High obsessive-compulsiveness (BSI), which is associated with excessive perfectionism and need for control, probably predisposed the subjects to seek treatment of their wrinkles. In the retinoic acid group but not the vehicle group there was an improvement in obsessive-compulsiveness and decreased anxiety in previously anxiety-provoking situations.

Topics: Administration, Cutaneous; Adult; Anxiety; Attitude to Health; Double-Blind Method; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Pharmaceutical Vehicles; Phobic Disorders; Placebos; Prospective Studies; Quality of Life; Self Concept; Skin; Skin Aging; Tretinoin

To test the hypothesis that Sydenham chorea (SC) immunoglobulin G (IgG) autoantibodies bind to specific neuronal surface proteins, whereas IgG from patients with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) or Tourette syndrome (TS) do not bind to neuronal surface proteins.. We used live differentiated SH-SY5Y cells, which have neuronal and dopaminergic characteristics. Using flow cytometry, we measured serum IgG cell surface binding in patients with SC (n = 11), PANDAS (n = 12), and TS (n = 11), and compared the findings to healthy controls (n = 11) and other neurologic controls (n = 11). In order to determine the specificity of binding to neuronal antigens, we also used a non-neuronal cell line, HEK 293.. The mean IgG cell surface binding was significantly higher in the SC group compared to all other groups (p < 0.001). By contrast, there was no difference between the PANDAS or TS groups and the controls. Using the non-neuronal HEK-293 cells, there was no significant difference in IgG cell surface binding between any groups.. Serum autoantibodies that bind to neuronal cell surface antigens are present in SC, but not in PANDAS or TS. These findings strengthen the hypothesis that SC is due to a pathogenic autoantibody, but weaken the autoantibody hypothesis in PANDAS and TS.

Topics: Adolescent; Antineoplastic Agents; Autoimmune Diseases; Cell Differentiation; Cell Line, Tumor; Child; Child, Preschool; Chorea; Female; Flow Cytometry; Humans; Immunoglobulin G; Male; Neuroblastoma; Neurons; Obsessive-Compulsive Disorder; Statistics, Nonparametric; Streptococcal Infections; Tourette Syndrome; Tretinoin