tretinoin and Nail-Diseases

Alitretinoin is an endogenous vitamin A derivative, 9-cis-retinoic acid. Its anti-inflammatory and immunomodulatory efficacy results from controlling leukocyte activity and cytokine production in keratinocytes. We describe three patients with severe chronic hand eczema accompanied by nail dystrophy, which was treated with alitretinoin 30 mg. Clinical evaluation at 6 months showed complete or almost complete clearing of the nail lesions. We also briefly review the literature reporting on nail dystrophy and alitretinoin treatment. There is some evidence of the clinical effect of retinoids on nail formation, owing to the presence of retinoid receptors on the nail matrix. Further studies are required to better understand the impact of alitretinoin in nail diseases. Our observation supports alitretinoin as a treatment option in retinoid-responsive dermatoses associated with nail involvement.

Topics: Adult; Alitretinoin; Anti-Inflammatory Agents; Chronic Disease; Dermatologic Agents; Eczema; Female; Hand Dermatoses; Humans; Male; Middle Aged; Nail Diseases; Treatment Outcome; Tretinoin

Treatment of nail lichen planus (LP) is difficult and an optimal therapy is lacking.. To report additional cases to the scant existing literature to learn more about therapeutic options for nail LP.. A regimen of 30 mg alitretinoin daily in 2 cases of nail LP over a period of 9 and 8 months, respectively.. In either case, nail changes showed marked improvement under oral alitretinoin therapy within 2 and 4 months, respectively. In both patients, affected nails with end-stage destructive pterygium were resistant to any previously applied therapy.. Alitretinoin is an effective treatment option for nail LP. We recommend early diagnosis of nail LP and early initiation of systemic therapy with alitretinoin to prevent the development of pterygium and permanent nail damage. However, further clinical studies are needed to establish reliable guidelines for nail LP therapy.

Topics: Alitretinoin; Antineoplastic Agents; Female; Fingers; Humans; Lichen Planus; Male; Middle Aged; Nail Diseases; Nails, Malformed; Tretinoin

There are multiple treatment modalities for periungual warts (PWs), although most are destructive and painful, limiting their application. Radiotherapy is a non-invasive method suitable for treating PW patients with contraindications to invasive procedures. To investigate the efficacy and safety of topical Tretinoin combined with Superficial X-ray therapy (SXRT) in treating PWs. This study included patients with 65 PWs who underwent treatment and a 3-month follow-up. Twenty four PWs were subjected to SXRT alone (group A). The remaining 41 PWs were subjected to SXRT combined with the application of the Tretinoin cream from the first day (group B). The overall clinical response rate, recurrence rates, cosmetic outcomes, and adverse events were observed during the follow-up period. The complete clearance rate (75% vs. 92.7% in groups A and B, respectively) and healing times (19.9 vs. 16.0 days in groups A and B, respectively) between the two groups were significantly different (p < 0.046 and 0.04), indicating the combination treatment is more effective. Notably, there was no damaging or permanent deformation on the nail, and the other adverse effects were mild and bearable. Topical Tretinoin combined with SXRT therapy is an effective strategy for treating PWs, with minor side effects. It is painless and with excellent cosmetic outcomes.

Topics: Humans; Nail Diseases; Treatment Outcome; Tretinoin; Warts; X-Ray Therapy

Topics: Aged; Alitretinoin; Antibodies, Monoclonal; Antineoplastic Agents; Drug Eruptions; Humans; Lichenoid Eruptions; Male; Nail Diseases; Nivolumab; Programmed Cell Death 1 Receptor; Tretinoin

Topics: Administration, Oral; Adult; Alitretinoin; Antineoplastic Agents; Female; Humans; Lichen Planus; Male; Middle Aged; Nail Diseases; Nails; Retinoid X Receptors; Tretinoin

Topics: Antineoplastic Agents; Humans; Nail Diseases; Tretinoin

Topics: Antineoplastic Agents; Female; Humans; Leukemia, Promyelocytic, Acute; Nail Diseases; Tretinoin

Topics: Alitretinoin; Chronic Disease; Cyclosporine; Dermatologic Agents; Drug Substitution; Eczema; Foot Dermatoses; Hand Dermatoses; Humans; Male; Middle Aged; Nail Diseases; Nails, Malformed; Time Factors; Treatment Outcome; Tretinoin

Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Humans; Leukemia, Promyelocytic, Acute; Male; Nail Diseases; Oxides; Remission Induction; Tretinoin

Transverse leukonychia (Leukonychia striata or Muehrcke's lines) has been described with the use of several drugs in oncology, mainly chemotherapeutic agents. This condition is thought to represent an abnormality of the vascular nail bed. As the diagnosis is clinical and the condition is self-limited, referral to other specialists is usually not required. We report the first case of transverse leukonychia related to the use of transretinoic acid for acute promyelocytic leukemia. Physician awareness of transverse leukonychia is important in order to reassure the patients and avoid unnecessary (and often not inexpensive) diagnostic work-up.

Topics: Aged; Antineoplastic Agents; Female; Humans; Leukemia, Promyelocytic, Acute; Nail Diseases; Tretinoin

Topics: Adult; Alitretinoin; Humans; Lichen Planus; Male; Nail Diseases; Treatment Outcome; Tretinoin

Topical hydroquinone is used in the treatment of a number of skin conditions. A 33-year-old male presented with brown discolouration of the fingernails following the application of 4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months. The discolouration resolved when the creams were ceased.

Topics: Administration, Topical; Adult; Coloring Agents; Facial Dermatoses; Follow-Up Studies; Humans; Hydroquinones; Hyperpigmentation; Male; Nail Diseases; Tretinoin

This paper reports on the association of two uncommon side effects of isotretinoin therapy for cystic acne: paronychia and excess granulation tissue in the nail sulci. An explanation for these side effects is suggested, but the exact pathogenesis remains obscure.

Topics: Acne Vulgaris; Adult; Female; Granuloma; Humans; Isotretinoin; Nail Diseases; Paronychia; Tretinoin

Two patients, a father and son, with pachyonychia congenita were treated with orally administered isotretinoin because the extreme deformity and discomfort associated with their massive keratoderma interfered with their work and school, respectively. While clinical benefits could not be sustained, electron microscopic findings compatible with suppression of abnormal keratinization were observed. In addition, skin biopsy samples were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and the gels were then subjected to a lectin overlay technique with concanavalin A labeled with iodine 125. The distribution of specific glycoproteins was found to be different for lesional as against normal epidermis. The procedure was repeated after oral treatment with isotretinoin. The labeled glycoprotein pattern of the lesional epidermis was clearly distinguishable from both the pretreatment lesional and the normal epidermis; it was mostly intermediate between the two. The normal epidermis was virtually unaffected by the retinoid treatment.

Topics: Adult; Child; Glycoproteins; Humans; Isotretinoin; Keratosis; Male; Microscopy, Electron; Nail Diseases; Skin; Tretinoin

Topics: Adult; Etretinate; Humans; Male; Middle Aged; Nail Diseases; Psoriasis; Tretinoin

One female patient 18 years old who suffers from Congenital Uaquioniquis since infancy, with serious alterations of nails, was treated with oral retinoid (Ro 10-9359-Tigason) during 20 months, with clinical improvement of her lesions. Clinical and laboratory controls were carried out periodically and they did not show any alterations. The only side-effects were itching, discrete hair loss headache, chelitis, all which were moderate in degree and transient.

Topics: Administration, Oral; Adolescent; Alopecia; Cheilitis; Etretinate; Female; Humans; Nail Diseases; Tretinoin

Topics: Anti-Inflammatory Agents; Humans; Nail Diseases; Photosensitivity Disorders; Propionates; Tretinoin

Topics: Etretinate; Humans; Male; Middle Aged; Nail Diseases; Tretinoin

The authors present three familial cases of Schonfeld's type I pachyonychia. This syndrome represents the association of pachyonychia with palmoplantar keratodermia, frictionnal keratosis and bullae, hyperidrosis, oral leucokeratosis. This genotype is present in the remaining family. Traumatisms produce or increase several symptoms as: a) palmoplantar keratodermia: voluminous callus confined to site of pressure; b) hyperkeratosis of the nails, with hyperplasia and papillomatosis of the nail bed and the hyponychium due to the frequents microtraumatisms of the finger-pulps; c) oral leucokeratosis. The authors describe the painful character of the palmoplantar lesions: walking and working with the hands are very difficult. They assert the outstanding action of aromatic retinoid (RO 10.9359) which entertains a dramatic improvement of the palmoplantar and pachyonychia lesions, the decrease of the pain. Now, the patient life is normal. In these three cases, an hyperuricemia is associated: this feature is probably a fortuitous association. One of these patients has a Lesch-Nyhan's syndrome.

Topics: Adult; Child; Etretinate; Humans; Male; Nail Diseases; Tretinoin