tretinoin and Miliaria

Miliaria crystallina is a benign, self-limiting disorder of the eccrine sweat glands characterized by the obstruction of the sweat ducts, which leads to secondary sweat retention into stratum corneum. We present two patients with MC during treatment with idarubicin and all-trans-retinoic acid (ATRA) for acute promyelocytic leukaemia (APL). Anthracyclines can be excreted through sweat and induce MC through exfoliation. The use of idarubicin in combination with ATRA would favour the process of producing a peeling effect. Reports of MC associated with idarubicin and ATRA are scarce. Recognizing this benign entity and its triggers will help to differentiate it from other skin reactions, improving the management of patients by avoiding unnecessary studies and treatments.

Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Humans; Idarubicin; Miliaria; Tretinoin

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Eruptions; Female; Humans; Idarubicin; Leukemia, Promyelocytic, Acute; Miliaria; Tretinoin

Milia are benign, superficial keratinaceous cysts that present as fine, small white papules. Milia en plaque is a rare, challenging-to-treat variant most often seen in the posterior auricular region. A total of 9 cases of milia en plaque have been reported in the pediatric literature to date. We report a case of milia en plaque of the nose in a 7-year-old boy, a novel site of involvement in the pediatric population, and successful treatment with the use of topical tretinoin. Topical retinoids offer an effective treatment option for the management of milia en plaque in the pediatric population.

Topics: Administration, Topical; Child; Dermoscopy; Drug Administration Schedule; Humans; Keratosis; Male; Miliaria; Nose Diseases; Treatment Outcome; Tretinoin

Topics: Administration, Topical; Adolescent; Biopsy; Body Piercing; Epidermal Cyst; Female; Humans; Keratolytic Agents; Lip; Lip Diseases; Miliaria; Recurrence; Tretinoin

A case of miliaria crystallina occurring with isotretinoin therapy in a patient with lamellar ichthyosis is described. To our knowledge, the association of miliaria crystallina with isotretinoin therapy has not been previously reported.

Topics: Adolescent; Humans; Ichthyosis; Isotretinoin; Male; Miliaria; Skin; Tretinoin