tretinoin and Leg-Ulcer

tretinoin has been researched along with Leg-Ulcer* in 2 studies

Other Studies

2 other study(ies) available for tretinoin and Leg-Ulcer

Article	Year
Successful treatment for leg ulcers due to hydroxyurea in a patient with chronic myelogenous leukaemia. Haematologia, 2002, Volume: 31, Issue:4 A 51-year-old male who had intractable leg ulcers during treatment for chronic myelogenous leukaemia with hydroxyurea (HU) is reported. His leg ulcers were treated by application of tretinoin tocoferil (TT) ointment after surgical debridement; good results were obtained. Although stopping HU administration is vitally important, surgical debridement and TT application are effective for treating leg ulcers due to HU. Topics: Antineoplastic Agents; Debridement; Drug Combinations; Humans; Hydroxyurea; Leg Ulcer; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Ointments; Tretinoin; Vitamin E	2002
Short-contact topical tretinoin therapy to stimulate granulation tissue in chronic wounds. Journal of the American Academy of Dermatology, 2001, Volume: 45, Issue:3 The use of retinoids in wound healing is increasing. It has been shown that retinoic acid reverses the inhibitory effects of glucocorticoids on wound healing and accelerates the formation of healthy granulation tissue. Pretreatment with tretinoin before epidermal injury such as chemical peeling and dermabrasion has shown accelerated wound healing. Enhanced healing of full-thickness skin wounds has also been demonstrated in early wound healing studies. However, tretinoin therapy can be quite irritating.. Our purpose was to observe the clinical and histologic effects of topical tretinoin solution 0.05% applied directly to the wound beds of chronic leg ulcerations.. We report on the cases of 5 patients with long-standing leg ulcerations. All were treated with topical tretinoin solution 0.05% applied directly to the wound bed. The tretinoin solution was left in contact with the ulcer bed for a maximum of 10 minutes daily and then rinsed with normal saline. Punch biopsy specimens were obtained from the wound beds at baseline and mid therapy. Standard wound care was continued throughout the study.. In this study we found that as early as 1 week after treatment with topical tretinoin solution 0.05%, there was increased granulation tissue first noted at the wound's edge. After 4 weeks of therapy with tretinoin, there was further stimulation of granulation tissue, new vascular tissue, and new collagen formation.. Short-contact tretinoin therapy is a novel modality in which to treat chronic ulcers and stimulate the formation of granulation tissue. Topics: Administration, Cutaneous; Aged; Chronic Disease; Female; Granulation Tissue; Humans; Keratolytic Agents; Leg Ulcer; Male; Middle Aged; Tretinoin; Wound Healing	2001

Article

Year

Successful treatment for leg ulcers due to hydroxyurea in a patient with chronic myelogenous leukaemia.

Haematologia, 2002, Volume: 31, Issue:4

A 51-year-old male who had intractable leg ulcers during treatment for chronic myelogenous leukaemia with hydroxyurea (HU) is reported. His leg ulcers were treated by application of tretinoin tocoferil (TT) ointment after surgical debridement; good results were obtained. Although stopping HU administration is vitally important, surgical debridement and TT application are effective for treating leg ulcers due to HU.

Topics: Antineoplastic Agents; Debridement; Drug Combinations; Humans; Hydroxyurea; Leg Ulcer; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Ointments; Tretinoin; Vitamin E

2002

Short-contact topical tretinoin therapy to stimulate granulation tissue in chronic wounds.

Journal of the American Academy of Dermatology, 2001, Volume: 45, Issue:3

The use of retinoids in wound healing is increasing. It has been shown that retinoic acid reverses the inhibitory effects of glucocorticoids on wound healing and accelerates the formation of healthy granulation tissue. Pretreatment with tretinoin before epidermal injury such as chemical peeling and dermabrasion has shown accelerated wound healing. Enhanced healing of full-thickness skin wounds has also been demonstrated in early wound healing studies. However, tretinoin therapy can be quite irritating.. Our purpose was to observe the clinical and histologic effects of topical tretinoin solution 0.05% applied directly to the wound beds of chronic leg ulcerations.. We report on the cases of 5 patients with long-standing leg ulcerations. All were treated with topical tretinoin solution 0.05% applied directly to the wound bed. The tretinoin solution was left in contact with the ulcer bed for a maximum of 10 minutes daily and then rinsed with normal saline. Punch biopsy specimens were obtained from the wound beds at baseline and mid therapy. Standard wound care was continued throughout the study.. In this study we found that as early as 1 week after treatment with topical tretinoin solution 0.05%, there was increased granulation tissue first noted at the wound's edge. After 4 weeks of therapy with tretinoin, there was further stimulation of granulation tissue, new vascular tissue, and new collagen formation.. Short-contact tretinoin therapy is a novel modality in which to treat chronic ulcers and stimulate the formation of granulation tissue.

Topics: Administration, Cutaneous; Aged; Chronic Disease; Female; Granulation Tissue; Humans; Keratolytic Agents; Leg Ulcer; Male; Middle Aged; Tretinoin; Wound Healing

2001