tretinoin and Keratitis--Herpetic

Ocular infection with HSV causes a chronic T cell-mediated inflammatory lesion in the cornea. Lesion severity is affected by the balance of different CD4 T cell subsets, with greater severity occurring when the activity of regulatory T cells (Tregs) is compromised. In this study, fate-mapping mice were used to assess the stability of Treg function in ocular lesions. We show that cells that were once Foxp3

Topics: Adoptive Transfer; Animals; Ascorbic Acid; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Plasticity; Cornea; Female; Forkhead Transcription Factors; Herpesvirus 1, Human; Homeodomain Proteins; Interleukin-12; Interleukin-2 Receptor alpha Subunit; Keratitis, Herpetic; Lymphocyte Activation; Mice; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Th1 Cells; Tretinoin