tretinoin and Ichthyosis--Lamellar

tretinoin has been researched along with Ichthyosis--Lamellar* in 2 studies

Trials

1 trial(s) available for tretinoin and Ichthyosis--Lamellar

Article	Year
Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole. Acta dermato-venereologica, 2009, Volume: 89, Issue:1 Lamellar ichthyosis is a keratinization disorder caused by TGM1, Ichthyin and several other gene mutations. A new treatment option is liarozole, which blocks the cytochrome P450 (CYP26)-mediated catabolism of endogenous all-trans retinoic acid. This study focuses on the expression of retinoid-related genes in ichthyotic epidermis before and after treatment with oral liarozole. We first compared the mRNA expression of cellular retinoic acid binding protein II (CRABPII), keratin (KRT) 2 and 4, CYP26A1 and B1, and two markers of inflammation (interleukin-1alpha and tumours necrosis factor (TNF)-alpha) in shave biopsies from 11 genetically defined, untreated patients and 12 age- and sex-matched healthy controls, finding no overt differences between the groups, besides elevated CRABPII expression. We then studied the biomarkers before and after 4 weeks of treatment with liarozole (75 or 150 mg/day), which produced a better therapeutic response in patients with Ichthyin (n=3) than in those with TGM1 (n=6) mutations. A significant decrease in the mRNA expression of KRT2 and TNF-alpha, and trends toward increased expression of KRT4 and CYP26A1 were observed in liarozole-treated patients, consistent with an increased retinoid stimulation of epidermis. However, there were no dose-related responses and the results of the immunostaining did not always parallel the mRNA findings. The results suggest that liarozole exerts a therapeutic effect in lamellar ichthyosis by mildly affecting the expression of retinoid- regulated genes in epidermis. Topics: Administration, Oral; Adolescent; Adult; Aged; Biomarkers; Dermatologic Agents; Double-Blind Method; Female; Humans; Ichthyosis, Lamellar; Imidazoles; Interleukin-1alpha; Male; Middle Aged; Polymerase Chain Reaction; Receptors, Retinoic Acid; RNA, Messenger; Skin; Tretinoin; Tumor Necrosis Factor-alpha	2009

Article

Year

Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole.

Acta dermato-venereologica, 2009, Volume: 89, Issue:1

Lamellar ichthyosis is a keratinization disorder caused by TGM1, Ichthyin and several other gene mutations. A new treatment option is liarozole, which blocks the cytochrome P450 (CYP26)-mediated catabolism of endogenous all-trans retinoic acid. This study focuses on the expression of retinoid-related genes in ichthyotic epidermis before and after treatment with oral liarozole. We first compared the mRNA expression of cellular retinoic acid binding protein II (CRABPII), keratin (KRT) 2 and 4, CYP26A1 and B1, and two markers of inflammation (interleukin-1alpha and tumours necrosis factor (TNF)-alpha) in shave biopsies from 11 genetically defined, untreated patients and 12 age- and sex-matched healthy controls, finding no overt differences between the groups, besides elevated CRABPII expression. We then studied the biomarkers before and after 4 weeks of treatment with liarozole (75 or 150 mg/day), which produced a better therapeutic response in patients with Ichthyin (n=3) than in those with TGM1 (n=6) mutations. A significant decrease in the mRNA expression of KRT2 and TNF-alpha, and trends toward increased expression of KRT4 and CYP26A1 were observed in liarozole-treated patients, consistent with an increased retinoid stimulation of epidermis. However, there were no dose-related responses and the results of the immunostaining did not always parallel the mRNA findings. The results suggest that liarozole exerts a therapeutic effect in lamellar ichthyosis by mildly affecting the expression of retinoid- regulated genes in epidermis.

Topics: Administration, Oral; Adolescent; Adult; Aged; Biomarkers; Dermatologic Agents; Double-Blind Method; Female; Humans; Ichthyosis, Lamellar; Imidazoles; Interleukin-1alpha; Male; Middle Aged; Polymerase Chain Reaction; Receptors, Retinoic Acid; RNA, Messenger; Skin; Tretinoin; Tumor Necrosis Factor-alpha

2009

Other Studies

1 other study(ies) available for tretinoin and Ichthyosis--Lamellar

Article	Year
Oral alitretinoin in congenital ichthyosis: a pilot study shows variable effects and a risk of central hypothyroidism. Acta dermato-venereologica, 2012, Volume: 92, Issue:3 Topics: Adult; Aged; Alitretinoin; Female; Humans; Hypothyroidism; Ichthyosis, Lamellar; Keratin-10; Keratolytic Agents; Male; Middle Aged; Mutation; Pilot Projects; Transglutaminases; Tretinoin	2012