tretinoin has been researched along with Hemangiosarcoma* in 2 studies
2 other study(ies) available for tretinoin and Hemangiosarcoma
| Article | Year |
|---|---|
Treatment of v-Ki-ras-transformed SVC1 cells with low retinoic acid induces malignancy reversion associated with ras p21 down-regulation.
The effect of nontoxic, low concentrations (10(-8) M) of retinoic acid (RA) for a relatively long time (28 days) on a Kirsten ras-virus transformed cell line (Ki-SVC1), derived from the rat seminal vesicle epithelium, was investigated. In these experimental conditions, the cell treatment with RA induced a decrease of the proliferation rate, apoptosis and a marked reduction of both anchorage-independent growth and tumorigenicity. These biological responses were either preceded or associated with important changes in adenylate cyclase/protein kinase C signaling pathways, the activation of important apoptosis-linked genes and a marked decrease of the v-Ki-ras p21 protein. The significance of these findings is discussed. Topics: Adenylyl Cyclases; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Transformed; Cell Membrane; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Down-Regulation; Hemangiosarcoma; Neoplasm Transplantation; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tretinoin | 2000 |
Therapeutic efficacy of interferon alfa-2a and 13-cis-retinoic acid in recurrent angiosarcoma of the head.
Topics: Aged; Antineoplastic Agents; Facial Neoplasms; Hemangiosarcoma; Humans; Interferon alpha-2; Interferon-alpha; Male; Neoplasm Recurrence, Local; Recombinant Proteins; Skin Neoplasms; Treatment Outcome; Tretinoin | 1999 |