tretinoin and Hamartoma

Topics: Administration, Cutaneous; Biopsy; Dermatologic Agents; Eyelid Diseases; Hamartoma; Humans; Male; Middle Aged; Remission Induction; Treatment Outcome; Tretinoin; Urinary Bladder Neoplasms

To observe the morphological features of the lumbosacral neural tube defects (NTDs) induced by all-trans retinoic acid (atRA) and to explore the pathogenesis of these defects.. Rat embryos with lumbosacral NTDs were obtained by treating pregnant rats with administration of atRA. Rat embryos were obtained by cesarean. Fetuses were sectioned and stained with hematoxylin-eosin (H&E). Relevant structures including caudal neural tube were examined. In the atRA-treated rats, about 48% embryos showed lumbosacral NTDs. There appeared a dorsally and rostrally situated, neural-plate-like structure (myeloschisis) and a ventrally and caudally located cell mass containing multiple canals (hamartoma) in the lumbosacral NTDs induced by atRA.. Retinoic acid could disturb the notochord and tail bud development in the process of primary and secondary neurulation in rat embryos, which cause lumbosacral NTDs including myeloschisis and hamartoma. The morphology is very similar to that happens in humans.

Topics: Abnormalities, Drug-Induced; Animals; Embryonic Development; Female; Gestational Age; Hamartoma; Keratolytic Agents; Neural Tube Defects; Notochord; Pregnancy; Rats; Rats, Wistar; Spinal Cord; Spinal Diseases; Spine; Teratogens; Tretinoin

Treatment of a linear verrucous epidermal nevus using topical 0.1% tretinoin cream and 5% 5-fluorouracil in a young patient is described. In 1994, successful topical therapy using this combination was described in the management of an inflammatory linear verrucous epidermal nevus. We report another case in which treatment of a noninflamed epidermal verrucous nevus with 0.1% tretinoin and 5% 5-fluorouracil resulted in significant improvement. An updated summary of the literature discussing management of epidermal nevi is presented.

Topics: Antimetabolites; Child; Drug Combinations; Fluorouracil; Hamartoma; Humans; Keratolytic Agents; Male; Skin Diseases; Tretinoin

Topics: Administration, Topical; Child; Fluorouracil; Hamartoma; Humans; Male; Neck; Occlusive Dressings; Skin Diseases; Tretinoin

Topics: Facial Neoplasms; Female; Hamartoma; Humans; Isotretinoin; Middle Aged; Neoplasms, Multiple Primary; Tretinoin