tretinoin and Genital-Neoplasms--Male

Extramammary Paget's disease (EMPD) is an uncommon skin neoplasm that usually affects the elderly population and occurs in the genital, anorectal, or axillary areas. The recommended treatment of EMPD involves surgical excision, including Mohs micrographic surgery; however, surgery is associated with a high rate of recurrence. There have been reports of successful treatment of recurrence with monochemotherapy involving topical imiquimod 5% cream. We report a case of EMPD recurrence after surgery that was resistant to imiquimod monotherapy but that completely resolved after imiquimod was combined with topical 5-fluorouracil (5-FU) and retinoic acid. To our knowledge, this is the first reported case of imiquimod combination therapy with 5-FU and retinoic acid for the treatment of recurrent EMPD.

Topics: Administration, Cutaneous; Aged; Aminoquinolines; Antineoplastic Combined Chemotherapy Protocols; Diagnosis, Differential; Fluorouracil; Genital Neoplasms, Male; Humans; Imiquimod; Male; Paget Disease, Extramammary; Tretinoin

Topics: Bowen's Disease; Carcinoma, Squamous Cell; Etretinate; Genital Neoplasms, Male; Humans; Male; Recurrence; Skin Neoplasms; Tretinoin