tretinoin and Fox-Fordyce-Disease

Topical vitamin A acid (VAA) has various mechanisms of action which may be responsible for its therapeutic success in many different disorders. Although the absorption, metabolism, and excretion of VAA are not completely understood, VAA appears to remain mainly on the skin surface. The question of carcinogenicity is unresolved, and more research is needed to clarify this problem. This article reviews the literature regarding the therapeutic uses of VAA and summarizes various investigators' experiences with VAA.

Topics: Acne Vulgaris; Animals; Callosities; Cocarcinogenesis; Fox-Fordyce Disease; Humans; Ichthyosis; Keloid; Keratoacanthoma; Keratosis; Lichen Planus; Melanoma; Melanosis; Molluscum Contagiosum; Nevus; Psoriasis; Skin Absorption; Skin Diseases; Skin Neoplasms; Tretinoin

Topics: Adolescent; Desonide; Drug Therapy, Combination; Female; Fox-Fordyce Disease; Humans; Keratolytic Agents; Tretinoin

A 1-year follow-up in a 12 year old girl suffering from Fox-Fordyce disease is reported. Reddish papules were found in the typical locations in the regions with a high density of apocrine glands. A biopsy specimen showed keratin plugs in the infundibula of apocrine glands. Since hormone therapy could not yet be given, external therapy only was performed, with good results.

Topics: Administration, Topical; Adrenal Cortex Hormones; Child; Diagnosis, Differential; Estradiol; Female; Fox-Fordyce Disease; Hair; Humans; Skin; Sweat Glands; Tretinoin

Topics: Female; Fox-Fordyce Disease; Humans; Middle Aged; Ointments; Tretinoin

Topics: Adult; Axilla; Female; Fox-Fordyce Disease; Hair; Humans; Ointments; Tretinoin