tretinoin and Facial-Asymmetry

Topics: Abnormalities, Multiple; Adult; Arthrogryposis; Facial Asymmetry; Female; Humans; Keratoderma, Palmoplantar; Neck; Scoliosis; Syndrome; Tretinoin

To obtain a better understanding of mandibulo-facial dysostosis and hemicraniofacial microsomia in man, the authors carried out a histologic and scanning electron microscope study of the facial malformations produced in mouse embryos by retinoic acid and methyl-triazene. The administration of 400 mg/kg 13 cis-retinoic acid (RA) to pregnant C57BL mice on day 9 of gestation produced anomalies of the cephalic extremity in the embryos resembling human mandibulo-facial dysostosis. The 64 embryos collected presented hypoplasia of the branchial arches or the snout in 79% of cases, auricular anomalies in 47% and ophthalmic anomalies in 12.5%. Fourteen NMRI mice on day 10.5 of gestation were treated with 1.5 mg (0.5 mg/kg) methyl-triazene (Methyl). The 126 embryos collected had developed a very high percentage of micromandibles and anomalies of both embryonic ears (94.6% to 100%). Finally, although the facial anomalies produced by retinoic acid resemble the human mandibulo-facial dysostosis syndrome, no correlation was found between hemicraniofacial microsomia and the administration of methyl-triazene.

Topics: Abnormalities, Drug-Induced; Adolescent; Animals; Child; Facial Asymmetry; Female; Humans; Male; Mandibulofacial Dysostosis; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Pregnancy; Tretinoin; Triazenes