tretinoin and Epidermal-Cyst

Of the many tattoo reactions the most common are allergic, granulomatous, lichenoid, photosensitive, pseudolymphomatous, and infectious. Eruptive milia are a rare complication with only three prior reports in the English literature. A 19-year-old African American female presented with tiny, white papules confined within the margins of a tattoo. She denied trauma or associated symptoms at the site. Biopsy demonstrated deposits of black granular material within the dermis and a small infundibular cyst; a diagnosis of eruptive milia within tattoo was made. The milia responded to treatment with urea 40% cream and tretinoin 0.1% cream. Given its rarity, it is important to recognize the presentation of this disorder as other tattoo reactions require more aggressive management. While further research is necessary to determine the exact pathogenesis of this condition, the authors propose a mechanism along with a review of the literature to discuss management.

J Drugs Dermatol. 2017;16(6):621-624.

Topics: Administration, Topical; Biopsy; Dermatologic Agents; Dermis; Epidermal Cyst; Female; Humans; Skin; Tattooing; Tretinoin; Urea; Young Adult

Milia are multiple, small, benign keratin-filled superficial epidermoid cysts which are classified as primary when they occur spontaneously or secondary when they result from skin trauma or disease. Multiple eruptive milia (MEM) refer to a condition characterized by a sudden eruption of a large number of milia. MEM may be familial, occur as part of a genodermatosis, or occur spontaneously when they are termed idiopathic. Idiopathic MEM are an exceedingly rare disease. We present the case of a 70-year-old Nigerian woman with idiopathic MEM.

Topics: Administration, Topical; Aged; Biopsy; Epidermal Cyst; Female; Humans; Keratolytic Agents; Keratosis; Lost to Follow-Up; Tretinoin

Topics: Administration, Topical; Adolescent; Biopsy; Body Piercing; Epidermal Cyst; Female; Humans; Keratolytic Agents; Lip; Lip Diseases; Miliaria; Recurrence; Tretinoin

Topics: Administration, Topical; Adolescent; Biopsy; Diagnosis, Differential; Epidermal Cyst; Female; Humans; Keratolytic Agents; Ointments; Skin; Skin Diseases; Tretinoin

Pachyonchia congenita (PC) is an uncommon autosomal dominant genodermatosis affecting the nails and other ectodermal tissues. The most striking features are symmetrically thickened dysmorphic nails and hyperkeratotic skin lesions. We report a case of pachyonychia congenita in a 30-year-old male patient who had thickening and gray-brown discoloration of all nails and many nodules on his back and neck. He also had hyperkeratotic skin lesions on both feet. His tongue had irregularly-shaped, whitish plaques. Histology of these nodules revealed the characteristic features of steatocystoma multiplex. After treatment with oral retinoic acid, his hyperkeratotic skin lesions improved.

Topics: Adult; Ectodermal Dysplasia; Epidermal Cyst; Humans; Keratoderma, Palmoplantar; Leukoplakia, Oral; Male; Nails, Malformed; Prognosis; Tretinoin

We have reported a case of eruptive vellus hair cysts, a rare type of acneiform eruption. Patients with unusual or refractory acneiform eruptions may have any of a variety of non-acne-vulgaris lesions. For this reason, biopsy and culture of these lesions may be helpful in establishing a correct diagnosis and determining proper treatment.

Topics: Acne Vulgaris; Adult; Diagnosis, Differential; Epidermal Cyst; Female; Hair; Humans; Tretinoin

Topics: Adult; Epidermal Cyst; Female; Humans; Tretinoin

A 20-year old man with steatocystoma multiplex and pseudofolliculitis barbae was treated unsuccessfully with oral isotretinoin. Consistent with findings from previous reports, treatment with isotretinoin should be reserved for patients with steatocystoma multiplex suppurativum.

Topics: Adult; Epidermal Cyst; Folliculitis; Humans; Isomerism; Isotretinoin; Male; Skin Diseases; Tretinoin

A patient with steatocystoma multiplex with multiple ruptured draining cysts and abscesses was treated with a twenty-week course of isotretinoin. Abscesses involuted and inflamed cysts shrank. The remission persisted for ten weeks after discontinuing therapy; subsequently cysts and abscesses occurred in multiple sites.

Topics: Adult; Epidermal Cyst; Humans; Isotretinoin; Male; Skin Diseases; Tretinoin

56 patients with nodulocystic acne, hidrosadenitis (2 cases) and steatocystoma multiplex (2 cases) were treated with oral isotretinoin. 52 patients cleared completely or were much improved without local treatment; 2 failures involved patients with steatocystoma, while 2 patients with ano-inguinal lesions were only improved. 19 patients received a dose of 0.5 mg/kg/day for six months; in 37 patients the dose was adapted to the initial response but did not exceed 1 mg/kg/day. Reversible elevated triglyceride concentration was observed in 5% of the patients. 18 patients were followed up and 4 (22%) presented moderate relapses.

Topics: Acne Vulgaris; Administration, Oral; Adolescent; Adult; Dose-Response Relationship, Drug; Epidermal Cyst; Female; Humans; Inflammation; Isotretinoin; Male; Sweat Gland Diseases; Tretinoin