tretinoin has been researched along with Cadmium-Poisoning* in 1 studies
1 other study(ies) available for tretinoin and Cadmium-Poisoning
| Article | Year |
|---|---|
Selenium and zinc: Two key players against cadmium-induced neuronal toxicity.
Cadmium (Cd), a worldwide occupational pollutant, is an extremely toxic heavy metal, capable of damaging several organs, including the brain. Its toxicity has been related to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The neurotoxic potential of Cd has been attributed to the changes induced in the brain enzyme network involved in counteracting oxidative stress. On the other hand, it is also known that trace elements, such as zinc (Zn) and selenium (Se), required for optimal brain functions, appears to have beneficial effects on the prevention of Cd intoxication. Based on this protective effect of Zn and Se, we aimed to investigate whether these elements could protect neuronal cells from Cd-induced excitotoxicity. The experiments, firstly carried out on SH-SY5Y catecholaminergic neuroblastoma cell line, demonstrated that the treatment with 10 μM cadmium chloride (CdCl Topics: Apoptosis; Cadmium Poisoning; Caspase 3; Cell Differentiation; Cell Line; Cell Survival; Endoplasmic Reticulum Stress; Humans; Neurites; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Reactive Oxygen Species; Selenium; Tretinoin; Zinc | 2018 |