tretinoin and Biliary-Tract-Diseases

tretinoin has been researched along with Biliary-Tract-Diseases* in 1 studies

Other Studies

1 other study(ies) available for tretinoin and Biliary-Tract-Diseases

Article	Year
Necessity of bile for and lack of inhibitory effect of retinoid on development of forestomach papillomas in nontreated mutant mice of the W/Wv genotype. Cancer research, 1982, Volume: 42, Issue:9 The pathogenesis of papillomas which developed spontaneously in the forestomach of WB X C57BL/6 F1-W/Wv mutant mice was investigated. The thickness of the forestomach epithelium was used as a quantitative index for development of papillomas. From the 15th day after birth, the forestomach epithelium of the W/Wv mice was significantly thicker than that of the congenic +/+ mice. Administration of aromatic retinoic acid analog (ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-3,7-dimethyl-2,4,6,8 -nonatetraenoate) did not suppress development of papillomas. Since papillomas did not appear in the stomach which was removed from the W/Wv embryos and grafted to the s.c. space produced in the back of the adult mice and since a considerable amount of bile reflux preceded development of papillomas, bile reflux may be a cause of papillomas in W/Wv mice. Topics: Alleles; Animals; Bile Reflux; Biliary Tract Diseases; Etretinate; Female; Genotype; Male; Mice; Mutation; Papilloma; Stomach; Stomach Neoplasms; Tretinoin	1982

Article

Year

Necessity of bile for and lack of inhibitory effect of retinoid on development of forestomach papillomas in nontreated mutant mice of the W/Wv genotype.

Cancer research, 1982, Volume: 42, Issue:9

The pathogenesis of papillomas which developed spontaneously in the forestomach of WB X C57BL/6 F1-W/Wv mutant mice was investigated. The thickness of the forestomach epithelium was used as a quantitative index for development of papillomas. From the 15th day after birth, the forestomach epithelium of the W/Wv mice was significantly thicker than that of the congenic +/+ mice. Administration of aromatic retinoic acid analog (ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-3,7-dimethyl-2,4,6,8 -nonatetraenoate) did not suppress development of papillomas. Since papillomas did not appear in the stomach which was removed from the W/Wv embryos and grafted to the s.c. space produced in the back of the adult mice and since a considerable amount of bile reflux preceded development of papillomas, bile reflux may be a cause of papillomas in W/Wv mice.

Topics: Alleles; Animals; Bile Reflux; Biliary Tract Diseases; Etretinate; Female; Genotype; Male; Mice; Mutation; Papilloma; Stomach; Stomach Neoplasms; Tretinoin

1982