tretinoin and Airway-Obstruction

tretinoin has been researched along with Airway-Obstruction* in 2 studies

Reviews

1 review(s) available for tretinoin and Airway-Obstruction

ArticleYear
Clinical relevance summary: Collagen vs elastin in pathogenesis of emphysema; cellular origin of elastases; bronchiolitis vs emphysema as a cause of airflow obstruction.
    Chest, 2000, Volume: 117, Issue:5 Suppl 1

    Topics: Airway Obstruction; Animals; Bronchiolitis; Collagen; Collagenases; Disease Models, Animal; Elastin; Humans; Prognosis; Pulmonary Alveoli; Pulmonary Emphysema; Tretinoin

2000

Other Studies

1 other study(ies) available for tretinoin and Airway-Obstruction

ArticleYear
Effects of tracheal occlusion with retinoic acid administration on normal lung development.
    Prenatal diagnosis, 2017, Volume: 37, Issue:5

    Tracheal occlusion (TO) is an investigational therapy for severe congenital diaphragmatic hernia that decreases pulmonary hypoplasia, but sustained TO also induces deficient surfactant synthesis. Intramuscular maternal administration of retinoic acid (RA) in a surgical rabbit model of congenital diaphragmatic hernia showed a beneficial effect on lung maturation. We evaluated the potential of RA delivery into the trachea and studied the combined effects of TO and RA on normal lung development.. Experiments were performed on normal rabbit fetuses. Liposomes and capric triglyceride (Miglyol. Tracheal occlusion increased lung weight and enhanced alveolar development but increased apoptotic activity and decreased surfactant expression. Tracheal injection of RA improved surfactant production to levels of normal controls.. We established the potential of liposome and Miglyol as RA vehicle for delivering this bioactive molecule in the fetal airways. Tracheal RA injection seems to oppose the effects of TO in fetuses with normal lungs. © 2017 John Wiley & Sons, Ltd.

    Topics: Airway Obstruction; Animals; Female; Fetal Organ Maturity; Lung; Pregnancy; Pulmonary Surfactants; Rabbits; Trachea; Tretinoin

2017