trelagliptin has been researched along with Infarction--Middle-Cerebral-Artery* in 1 studies
1 other study(ies) available for trelagliptin and Infarction--Middle-Cerebral-Artery
| Article | Year |
|---|---|
Trelagliptin Mitigates Macrophage Infiltration by Preventing the Breakdown of the Blood-Brain Barrier in the Brain of Middle Cerebral Artery Occlusion Mice.
Stroke is a significant cardiovascular disease that influences the health of human beings all over the world, especially the elderly population. It is reported that the blood-brain barrier (BBB) can be easily destroyed by stroke, which is one of the main factors responsible for macrophage infiltration and central nervous inflammation. Here, we report the protective effects of Trelagliptin against BBB injury and macrophage infiltration. Our results indicate that the infraction volume, the neurological score, and macrophage infiltration staining with CD68 were increased in middle cerebral artery occlusion (MCAO) mice but significantly reversed by treatment with Trelagliptin. Additionally, Trelagliptin reduced the permeability of the BBB by increasing the expression of the tight junction zonula occludens protein-1 (ZO-1) in the cerebral cortex. In an Topics: Animals; Blood-Brain Barrier; Brain; Infarction, Middle Cerebral Artery; Macrophages; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Uracil | 2021 |