trehangelin-a and Hemolysis

trehangelin-a has been researched along with Hemolysis* in 1 studies

Other Studies

1 other study(ies) available for trehangelin-a and Hemolysis

ArticleYear
Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510.
    The Journal of antibiotics, 2013, Volume: 66, Issue:6

    Three new natural products, designated trehangelins A, B and C, were isolated by solvent extraction, silica gel and octadecylsilyl silica gel column chromatographies and subsequent preparative HPLC from the cultured broth of an endophytic actinomycete strain, Polymorphospora rubra K07-0510. The trehangelins consisted of a trehalose moiety and two angelic acid moieties. Trehangelins A (IC50 value, 0.1 mg ml(-1)) and C (IC50 value, 0.4 mg ml(-1)), with symmetric structures, showed potent inhibitory activity against hemolysis of red blood cells induced by light-activated pheophorbide a. However, trehangelin B, with an asymmetric structure, displayed only a slight inhibition (IC50 value, 1.0 mg ml(-1)).

    Topics: Actinobacteria; Biological Products; Cell Survival; Chemical Phenomena; Chlorophyll; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endophytes; Erythrocytes; HEK293 Cells; Hemolysis; HT29 Cells; Humans; Inhibitory Concentration 50; Molecular Conformation; Orchidaceae; Oxidative Stress; Plant Roots; Radiation-Protective Agents; Radiation-Sensitizing Agents; Trehalose

2013
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