Compounds > trehalose
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trehalose and Protein Aggregation, Pathological

trehalose has been researched along with Protein Aggregation, Pathological in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (91.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Aravindan, S; Chen, KY; Chen, S; Choudhry, H; Liu, AYC; Molfetta, C1
Cho, ED; Jung Ahn, W; Lee, HJ; Lee, SJ; Won Lee, K; Yoon, YS1
Agarwal, M; Deep, S; Katyal, N; Kumar, V; Sen, R1
Çamdere, G; Hu, X; Kim, SX; Koshland, D; Tapia, H1
Abramov, D; Burré, J; Carnazza, KE; Dittman, JS; Guiberson, NGL; Kharel, P; Pineda, A; Wragg, RT1
Hoffmann, AC; Kazman, A; Klucken, J; Menges, S; Mielenz, D; Minakaki, G; Salvi, R; Savitskiy, S; Vicente Miranda, H; Winkler, J; Xiang, W1
Banerjee, R; Chaudhary, RK; Kardani, J; Roy, I; Singh, K1
Chao, CY; Chen, CM; Chen, IC; Chen, WL; Hsieh-Li, HM; Hsu, KC; Lee, CM; Lee, GC; Lee-Chen, GJ; Lin, CH; Lin, TH; Wu, YC; Wu, YR; Yang, JM1
Imaizumi, T; Itoh, K; Maruyama, A; Matsumiya, T; Miki, Y; Mimura, J; Mori, F; Tanji, K; Wakabayashi, K1
Feng, C; Ge, P; Li, Y; Lu, B; Luo, T; Luo, Y; Piao, M; Wang, C; Zhang, Y1
Darley-Usmar, V; Redmann, M; Volpicelli-Daley, L; Wani, WY; Zhang, J1
Carlisle, RE; Dickhout, JG; Upagupta, C1

Other Studies

12 other study(ies) available for trehalose and Protein Aggregation, Pathological

ArticleYear
Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington's disease cell models.
    Scientific reports, 2020, 09-23, Volume: 10, Issue:1

    Topics: Animals; Autophagy; Cyclic AMP Response Element-Binding Protein; Gene Knockdown Techniques; Glycerol; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Huntingtin Protein; Huntington Disease; Mutation; Osmolar Concentration; PC12 Cells; Protein Aggregation, Pathological; Protein Folding; Rats; Sorbitol; Sucrose; Trehalose

2020
Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation.
    Cell death & disease, 2017, 10-05, Volume: 8, Issue:10

    Topics: alpha-Synuclein; Animals; Autophagosomes; Autophagy; Cell Survival; Disaccharides; Humans; Lysosomes; Microtubule-Associated Proteins; Neurons; Parkinson Disease; Primary Cell Culture; Protein Aggregation, Pathological; Rats; RNA-Binding Proteins; Trehalose

2017
Paradoxical Effect of Trehalose on the Aggregation of α-Synuclein: Expedites Onset of Aggregation yet Reduces Fibril Load.
    ACS chemical neuroscience, 2018, 06-20, Volume: 9, Issue:6

    Topics: alpha-Synuclein; Amyloid; Humans; Molecular Dynamics Simulation; Parkinson Disease; Protein Aggregation, Pathological; Protein Conformation; Trehalose

2018
Synergy between the small intrinsically disordered protein Hsp12 and trehalose sustain viability after severe desiccation.
    eLife, 2018, 07-16, Volume: 7

    Topics: Cell Membrane; Dehydration; Heat-Shock Proteins; Intrinsically Disordered Proteins; Microbial Viability; Protein Aggregation, Pathological; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Stress, Physiological; Trehalose

2018
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones.
    Nature communications, 2018, 09-28, Volume: 9, Issue:1

    Topics: Animals; Brain Diseases; Caenorhabditis elegans Proteins; Cell Line, Tumor; Cells, Cultured; HEK293 Cells; Humans; Mice, Knockout; Munc18 Proteins; Mutation, Missense; Neurons; Organic Chemicals; Phenylbutyrates; Protein Aggregates; Protein Aggregation, Pathological; Saccharomyces cerevisiae Proteins; Sorbitol; Trehalose

2018
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.
    Scientific reports, 2019, 01-24, Volume: 9, Issue:1

    Topics: alpha-Synuclein; Animals; Autophagy; Cell Line, Tumor; Escherichia coli; Glioma; Humans; Lysosomes; Neurons; Parkinson Disease; Protein Aggregation, Pathological; Rats; Rats, Wistar; Recombinant Proteins; Sirolimus; Trehalose

2019
Deciphering the roles of trehalose and Hsp104 in the inhibition of aggregation of mutant huntingtin in a yeast model of Huntington's disease.
    Neuromolecular medicine, 2014, Volume: 16, Issue:2

    Topics: Cytosol; Endocytosis; Gene Expression Regulation, Fungal; Genes, Reporter; Heat-Shock Proteins; Humans; Huntingtin Protein; Mutation, Missense; Nerve Tissue Proteins; Oxidative Stress; Peptide Fragments; Prions; Protein Aggregates; Protein Aggregation, Pathological; Protein Folding; Protein Transport; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Trehalase; Trehalose

2014
Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3.
    CNS & neurological disorders drug targets, 2016, Volume: 15, Issue:3

    Topics: Analysis of Variance; Ataxin-3; Autophagy; Cell Line, Tumor; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Lactulose; Melibiose; Neuroblastoma; Peptides; Protein Aggregation, Pathological; Reactive Oxygen Species; Repressor Proteins; Transfection; Trehalose

2016
Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.
    Biochemical and biophysical research communications, 2015, Oct-02, Volume: 465, Issue:4

    Topics: Administration, Oral; alpha-Synuclein; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Disease Models, Animal; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Lewy Body Disease; Maltose; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Molecular Chaperones; Protein Aggregation, Pathological; Receptors, sigma; Sigma-1 Receptor; Solubility; Trehalose

2015
Trehalose Inhibits Protein Aggregation Caused by Transient Ischemic Insults Through Preservation of Proteasome Activity, Not via Induction of Autophagy.
    Molecular neurobiology, 2017, Volume: 54, Issue:9

    Topics: Animals; Autophagy; Brain Ischemia; Cell Line, Tumor; Humans; Male; Proteasome Endopeptidase Complex; Protein Aggregation, Pathological; Rats; Rats, Wistar; Trehalose

2017
Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.
    Redox biology, 2017, Volume: 11

    Topics: alpha-Synuclein; Animals; Apoptosis; Autophagy; Cell Survival; Humans; Mice; Neurons; Parkinson Disease; Protein Aggregation, Pathological; TOR Serine-Threonine Kinases; Trehalose

2017
Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.
    Biochemical and biophysical research communications, 2017, 04-22, Volume: 486, Issue:1

    Topics: Benzothiazoles; Cell Line; Docosahexaenoic Acids; Endoplasmic Reticulum Stress; Epithelial Cells; Glycerol; Humans; Kidney Tubules, Proximal; Molecular Weight; Phenylbutyrates; Protein Aggregates; Protein Aggregation, Pathological; Protein Folding; Staining and Labeling; Taurochenodeoxycholic Acid; Thapsigargin; Thiazoles; Trehalose; Unfolded Protein Response; Xenobiotics

2017