Page last updated: 2024-08-18

trehalose and Dry Eye

trehalose has been researched along with Dry Eye in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (13.04)29.6817
2010's9 (39.13)24.3611
2020's11 (47.83)2.80

Authors

AuthorsStudies
Cagini, C; Di Lascio, G; Lupidi, M; Mariniello, M; Meschini, G; Messina, M; Torroni, G1
Diz-Arias, E; Fernández-Jimenez, E; Peral, A1
Huang, Q; Huang, W; Li, E; Wang, L; Xiang, Z; Zhou, J1
Blasco-Martínez, A; Chiambaretta, F; Del Prado Sanz, E; Farrant, S; Mateo-Orobia, AJ; Pablo-Júlvez, LE1
D'souza, S; Ghosh, A; Jeyabalan, N; Nelson, EJR; Panigrahi, T; Sethu, S; Shetty, R; Shivakumar, S1
Kaarniranta, K; Laihia, J1
Mirsaitova, DR; Panova, IE; Titov, AV1
Kucuk, B; Ozsaygili, C; Yildirim, Y1
Anfuso, CD; Corsaro, R; Cristaldi, M; Lupo, G; Olivieri, M; Pezzino, S; Rusciano, D; Spampinato, G1
Balestrazzi, A; Cagini, C; Di Lascio, G; Mariniello, M; Martone, G; Torroni, G1
Brar, S; Ganesh, S; Vanga, HR1
Esclatine, A; Hernandez, E; Labetoulle, M; Lussignol, M; Taisne, C1
Bremond-Gignac, D; Chiambaretta, F; Doan, S1
Cejka, C; Cejkova, J; Kubinova, S1
Guthoff, RF; Hovakimyan, M; Ramoth, T; Stachs, O1
Grzesiak, J; Hill-Bator, A; Marycz, K; Misiuk-Hojło, M1
Baar, C; dos Santos, VA; Garhofer, G; Kaya, S; Nepp, J; Rosner, P; Schmetterer, L; Schmidl, D; Unterhuber, A; Werkmeister, RM; Witkowska, KJ1
Baudouin, C; Chiambaretta, F; Doan, S; Fekih, LE; Khairallah, M; Labetoulle, M; Messaoud, R; Rocher, N1
Chen, W; Lin, Y; Liu, M; Luyckx, J; Qu, J; Ye, Y; Zhang, J; Zhang, X1
Baudouin, C; Chen, W; Li, J; Liu, G; Roubeix, C; Shi, S; Wang, Y1
Guthoff, R; Hovakimyan, M; Löbler, M; Ramoth, T; Schmitz, KP; Stachs, O; Witt, M1
Matsuo, T; Morimoto, N; Tsuchida, Y1
Matsuo, T1

Reviews

2 review(s) available for trehalose and Dry Eye

ArticleYear
Trehalose for Ocular Surface Health.
    Biomolecules, 2020, 05-25, Volume: 10, Issue:5

    Topics: Animals; Antioxidants; Clinical Trials as Topic; Cornea; Corneal Diseases; Dry Eye Syndromes; Humans; Trehalose

2020
Trehalose in ophthalmology.
    Histology and histopathology, 2019, Volume: 34, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Clinical Trials as Topic; Cornea; Disease Models, Animal; Dry Eye Syndromes; Humans; Ophthalmology; Oxidative Stress; Rabbits; Trehalose; Ultraviolet Rays; Wound Healing

2019

Trials

10 trial(s) available for trehalose and Dry Eye

ArticleYear
Dry eye and inflammation of the ocular surface after cataract surgery: effectiveness of a tear film substitute based on trehalose/hyaluronic acid vs hyaluronic acid to resolve signs and symptoms.
    Journal of cataract and refractive surgery, 2021, 11-01, Volume: 47, Issue:11

    Topics: Cataract; Dry Eye Syndromes; Humans; Hyaluronic Acid; Inflammation; Prospective Studies; Tears; Trehalose

2021
Trehalose augments autophagy to mitigate stress induced inflammation in human corneal cells.
    The ocular surface, 2019, Volume: 17, Issue:4

    Topics: Autophagy; Biomarkers; Blotting, Western; Cells, Cultured; Cornea; Cytokines; Dry Eye Syndromes; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inflammation; Male; Prospective Studies; Single-Blind Method; Tears; Trehalose

2019
The short term effect of trehalose and different doses of sodium hyaluronate on anterior corneal aberrations in dry eye patients.
    Cutaneous and ocular toxicology, 2021, Volume: 40, Issue:1

    Topics: Aberrometry; Adult; Aged; Cornea; Dry Eye Syndromes; Female; Humans; Hyaluronic Acid; Lubricant Eye Drops; Male; Middle Aged; Prospective Studies; Treatment Outcome; Trehalose; Young Adult

2021
Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders.
    International ophthalmology, 2021, Volume: 41, Issue:9

    Topics: Cataract; Dry Eye Syndromes; Female; Humans; Hyaluronic Acid; Male; Ophthalmic Solutions; Prospective Studies; Tears; Trehalose

2021
Comparison of efficacy of trehalose-based eye drops versus topical 0.1% Hyaluronic Acid for management of clinically significant dry eye using non-invasive investigational modalities.
    International ophthalmology, 2021, Volume: 41, Issue:10

    Topics: Adult; Dry Eye Syndromes; Humans; Hyaluronic Acid; Middle Aged; Ophthalmic Solutions; Prospective Studies; Tears; Trehalose

2021
Comparison of the effect of a hyaluronate-trehalose solution to hyaluronate alone on Ocular Surface Disease Index in patients with moderate to severe dry eye disease.
    Current medical research and opinion, 2018, Volume: 34, Issue:8

    Topics: Adult; Dry Eye Syndromes; Female; Humans; Hyaluronic Acid; Male; Middle Aged; Ophthalmic Solutions; Single-Blind Method; Trehalose

2018
[Characterisation of tear film dynamics after application of trehalose for treatment of dry eye].
    Klinische Monatsblatter fur Augenheilkunde, 2013, Volume: 230, Issue:12

    Topics: Adult; Diagnostic Techniques, Ophthalmological; Dry Eye Syndromes; Female; Humans; Male; Middle Aged; Ophthalmic Solutions; Reproducibility of Results; Sensitivity and Specificity; Surface Tension; Tears; Treatment Outcome; Trehalose; Viscosity; Young Adult

2013
Tear film thickness after treatment with artificial tears in patients with moderate dry eye disease.
    Cornea, 2015, Volume: 34, Issue:4

    Topics: Administration, Topical; Adult; Double-Blind Method; Drug Combinations; Dry Eye Syndromes; Female; Fourier Analysis; Humans; Hyaluronic Acid; Lubricant Eye Drops; Male; Middle Aged; Surveys and Questionnaires; Tears; Tomography, Optical Coherence; Trehalose; Viscosupplements

2015
A randomized, controlled study of the efficacy and safety of a new eyedrop formulation for moderate to severe dry eye syndrome.
    European journal of ophthalmology, 2017, Jan-19, Volume: 27, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Drug Combinations; Dry Eye Syndromes; Female; France; Humans; Hyaluronic Acid; Male; Middle Aged; Ophthalmic Solutions; Patient Satisfaction; Surveys and Questionnaires; Treatment Outcome; Trehalose; Young Adult

2017
Trehalose eye drops in the treatment of dry eye syndrome.
    Ophthalmology, 2002, Volume: 109, Issue:11

    Topics: Adult; Aged; Double-Blind Method; Dry Eye Syndromes; Female; Fluorescein; Humans; Male; Middle Aged; Ophthalmic Solutions; Rose Bengal; Safety; Treatment Outcome; Trehalose

2002

Other Studies

11 other study(ies) available for trehalose and Dry Eye

ArticleYear
Improving ocular surface comfort in contact lens wearers.
    Contact lens & anterior eye : the journal of the British Contact Lens Association, 2022, Volume: 45, Issue:3

    Topics: Contact Lenses, Hydrophilic; Dry Eye Syndromes; Fluorescein; Humans; Lubricant Eye Drops; Prospective Studies; Tears; Trehalose

2022
Autophagy Protects Ocular Surface Against Overactivated Inflammation by Degrading Retinoic Acid-Induced Gene-I in Human Conjunctival Epithelial Cells.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2022, Volume: 38, Issue:5

    Topics: Autophagy; Dry Eye Syndromes; Epithelial Cells; Humans; Inflammation; RNA; Trehalose; Tretinoin

2022
Efficacy of artificial tears containing trehalose and hyaluronic acid for dry eye disease in women aged 42-54 versus ≥ 55 years.
    Contact lens & anterior eye : the journal of the British Contact Lens Association, 2023, Volume: 46, Issue:4

    Topics: Dry Eye Syndromes; Female; Humans; Hyaluronic Acid; Hyperemia; Lubricant Eye Drops; Male; Tears; Trehalose

2023
[The effects of a trehalose-based drug used after laser keratorefractive surgeries].
    Vestnik oftalmologii, 2020, Volume: 136, Issue:4

    Topics: Dry Eye Syndromes; Humans; Keratomileusis, Laser In Situ; Myopia; Tears; Trehalose

2020
Poly 2-methacryloyloxyethyl Phosphorylcholine Protects Corneal Cells and Contact Lenses from Desiccation Damage.
    Optometry and vision science : official publication of the American Academy of Optometry, 2021, 02-01, Volume: 98, Issue:2

    Topics: Animals; Cells, Cultured; Contact Lenses, Hydrophilic; Desiccation; Dry Eye Syndromes; Epithelium, Corneal; Humans; Hyaluronic Acid; Hypromellose Derivatives; Phosphorylcholine; Polymethacrylic Acids; Prosthesis Failure; Sodium Dodecyl Sulfate; Swine; Trehalose

2021
Commercially Available Eye Drops Containing Trehalose Protect Against Dry Conditions via Autophagy Induction.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2021, Volume: 37, Issue:7

    Topics: Autophagy; Dry Eye Syndromes; HeLa Cells; Humans; Lubricant Eye Drops; Trehalose; Tumor Cells, Cultured

2021
Trehalose-based eye drops preserve viability and functionality of cultured human corneal epithelial cells during desiccation.
    BioMed research international, 2014, Volume: 2014

    Topics: Cell Line; Cell Survival; Cells, Cultured; Desiccation; Dry Eye Syndromes; Epithelium, Corneal; Humans; Ophthalmic Solutions; Trehalose

2014
Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis.
    Experimental eye research, 2009, Volume: 89, Issue:3

    Topics: Animals; Apoptosis; Conjunctiva; Disease Models, Animal; Drug Evaluation, Preclinical; Dry Eye Syndromes; Epithelium, Corneal; Female; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Ophthalmic Solutions; Tears; Trehalose

2009
Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system.
    Molecular vision, 2012, Volume: 18

    Topics: Animals; Base Sequence; Cornea; Cornified Envelope Proline-Rich Proteins; Cytokines; Disease Models, Animal; DNA Primers; Dry Eye Syndromes; Female; Gene Expression Profiling; HSP70 Heat-Shock Proteins; Immunohistochemistry; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred C57BL; Occludin; Ophthalmic Solutions; Protein Precursors; RNA, Messenger; Trehalose

2012
Evaluation of protective effects of trehalose on desiccation of epithelial cells in three dimensional reconstructed human corneal epithelium.
    Current eye research, 2012, Volume: 37, Issue:11

    Topics: Cell Count; Cell Survival; Desiccation; Dry Eye Syndromes; Epithelium, Corneal; Humans; Imaging, Three-Dimensional; Microscopy, Confocal; Ophthalmic Solutions; Tight Junctions; Tissue Culture Techniques; Tomography, Optical Coherence; Trehalose

2012
Trehalose protects corneal epithelial cells from death by drying.
    The British journal of ophthalmology, 2001, Volume: 85, Issue:5

    Topics: Cell Survival; Cells, Cultured; Desiccation; Dose-Response Relationship, Drug; Dry Eye Syndromes; Epithelium, Corneal; Fluorescent Dyes; Humans; Maltose; Ophthalmic Solutions; Statistics, Nonparametric; Trehalose

2001