trehalose has been researched along with Disease Models, Animal in 81 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 12 (14.81) | 29.6817 |
2010's | 44 (54.32) | 24.3611 |
2020's | 25 (30.86) | 2.80 |
Authors | Studies |
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Akopyan, AA; Dubrovina, NI; Ovsyukova, MV; Pupyshev, AB; Tenditnik, MV; Tikhonova, MA | 1 |
Geisslinger, G; Kraft, V; Schmitz, K; Sisignano, M; Tegeder, I; Wilken-Schmitz, A | 1 |
Akopyan, AA; Amstislavskaya, TG; Bgatova, NP; Dubrovina, NI; Goncharova, NV; Korolenko, TA; Lin, CL; Ovsyukova, MV; Pupyshev, AB; Tenditnik, MV; Tikhonova, MA; Zavjalov, EL | 1 |
Guan, D; Jia, R; Qian, W; Shi, R; Wu, Y | 1 |
Akopyan, AA; Amstislavskaya, TG; Bashirzade, AA; Belichenko, VM; Dubrovina, NI; Fedoseeva, LA; Korolenko, TA; Ovsyukova, MV; Pupyshev, AB; Tenditnik, MV; Tikhonova, MA | 1 |
Choi, HJ; Huh, YE; Kwon, Y; Moon, SH | 1 |
Deng, Y; Jing, MJ; Liu, C; Liu, K; Liu, W; Ma, Z; Wang, C; Xu, B; Yan, DY | 1 |
Khaksari, M; Mirzaee, M; Nasouti, R; Nazari-Robati, M | 1 |
Li, Y; Liu, X; Pan, J; Sun, L; Xiao, Y; Zhang, J; Zhang, Z; Zhao, Q | 1 |
Bellisario, V; Berry, A; Chiarotti, F; Cirulli, F; Foglieni, C; Gambardella, L; Lombardi, M; Marconi, M; Matarrese, P; Musillo, C; Vona, R | 1 |
Chintapalli, SV; Crowley, JR; DeBosch, BJ; Ferey, JL; Good, M; Heitmeier, MR; Higashiyama, T; Higgins, CB; Hruz, PW; Mihi, B; Shaikh, N; Shankar, K; Stothard, AI; Swarts, BM; Tarr, PI; Wankhade, UD; Zhang, Y | 1 |
Ban, J; Chen, J; Chen, S; Chen, Y; He, X; He, Y; Li, C; Liu, F; Wei, Y | 1 |
Gao, H; Huang, S; Jia, Z; Liu, S; Wang, P; Yang, Y; Zhang, A; Zhang, Y; Zhou, N | 1 |
Chung, UI; Echigo, R; Karatsu, K; Mochizuki, M; Sasaki, N; Shimohata, N; Suzuki, S; Uchikawa, S | 1 |
Cavadas, C; Cunha-Santos, J; Gaspar, LS; Greif, H; Nobre, RJ; Nóbrega, C; Paixão, S; Pereira de Almeida, L; Santana, MM; Silva, TP; Trevino-Garcia, A | 1 |
Arakawa, H; Furuki, T; Hisaeda, H; Imai, T; Izumi, T; Kato, T; Obi, S; Ohno, H; Ohshima, N; Ohtsu, Y; Olia, A; Sakurai, M; Shimokawa, C; Suzue, K; Takeuchi, T | 1 |
Jiang, Q; Shi, D; Shi, T; Wang, R; Wu, R; Xu, X; Yan, W | 1 |
Hsiung, GR; Liu, Y; Song, W; Wang, J | 1 |
Ariyasu, T; Baba, R; Harada, M; Hino, K; Honma, Y; Katsuki, Y; Kawashima, A; Mihara, H; Sato-Morita, M | 1 |
Chen, D; Wang, L; Xiao, Z; Yang, J; Zhou, S | 1 |
Gao, F; He, W; Hu, S; Lan, Y; Li, Z; Wang, G; Wang, X; Wang, Z; Xu, B; Zhang, J; Zhao, K | 1 |
Ganesh, S; Sinha, P; Verma, B | 1 |
Chen, Y; Dai, L; Hu, Q; Song, Z; Wang, L; Xiong, J; Yuan, H; Zheng, C; Zhu, L | 1 |
Deng, J; Gong, Y; Guo, T; Hao, S; Hou, Z; Ren, P; Wang, B | 1 |
Dubey, SK; K C, S; Kakoty, V; Kesharwani, P; Taliyan, R; Yang, CH | 1 |
Abd-Elsalam, WH; Abouelatta, SM; Saber, MM | 1 |
Dubey, SK; K C, S; Kakoty, V; Taliyan, R; Yang, CH | 1 |
Adlard, PA; Finkelstein, DI; Hare, DJ; Perronnes, K; Portbury, AJ; Portbury, SD; Sgambelloni, C | 1 |
Biczo, G; Dawson, D; Elperin, J; French, SW; Gorelick, FS; Gretler, S; Gukovskaya, AS; Gukovsky, I; Hegyi, P; Husain, SZ; Lotshaw, E; Lugea, A; Malla, SR; Mareninova, OA; Rakonczay, Z; Ruchala, P; Shalbueva, N; Vegh, ET; Wen, L; Whitelegge, J | 1 |
Bianchi, F; Boppana, VS; Del Re, DP; Forte, M; Frati, G; Nagarajan, N; Rubattu, S; Sadoshima, J; Saito, T; Schirone, L; Sciarretta, S; Shirakabe, A; Tong, M; Valenti, V; Vecchione, C; Volpe, M; Yee, D; Zhai, P | 1 |
Adlard, PA; Bishop, DP; Doble, PA; Finkelstein, DI; Hare, DJ; Portbury, SD | 1 |
Muller, S | 1 |
Massenzio, F; Mengoni, I; Miti, A; Monti, B; Peña-Altamira, E; Petralla, S; Piffaretti, D; Polazzi, E; Virgili, M; Zuccheri, G | 1 |
Akopyan, AA; Dubrovina, NI; Korolenko, TA; Pupyshev, AB; Tenditnik, MV; Tikhonova, MA | 1 |
Cejka, C; Cejkova, J; Kubinova, S | 1 |
DeBosch, BJ; Zhang, Y | 1 |
Bultman, KM; Cramer, RA; Dhingra, S; Kerkaert, JD; Thammahong, A | 1 |
Gonzalez-y-Merchand, J; Helguera-Repetto, C; Hernández-Pando, R; Ramírez, AS; Rodríguez, JE; Salas, LP; Soto, CY | 1 |
Hamaishi, M; Imai, K; Isaka, M; Orihashi, K; Sueda, T; Takahashi, S | 1 |
Balroop, J; Kashem, Z; Ko, EH; Lai, M; Lee, H; Wei, N; Zhang, M | 1 |
Chen, S; Jia, L; Le, W; Shen, Y; Song, L; Tang, Y; Zhang, X | 1 |
Hatano, M; Nomoto, A; Ohba, S; Someno, T; Wada, S | 1 |
Fan, Y; Li, J; Shi, R; Wang, X; Zhao, S | 1 |
Emanuele, E | 1 |
Abe, N; Doi, K; Iwata, K; Katoh, M; Nojima, H; Ohata, A; Saito, Y; Tamura, N | 1 |
Borchardt, RK; Botts, MR; Huang, M; Hull, CM | 1 |
Cheon, H; Cho, JM; Jeong, YT; Jin, SM; Kang, SW; Kim, J; Kim, JH; Kim, KH; Kim, S; Komatsu, M; Lee, MK; Lee, MS; Lim, YM; Oh, SH; Quan, W | 1 |
Beger, RD; Bowyer, JF; Chigurupati, S; Hanig, JP; Mann, D; Paule, MG; Raymick, J; Sarkar, S; Schmitt, T; Schmued, LC | 1 |
Ballester, MI; Berthier, A; García-Cabrero, AM; Heredia, M; Payá, M; Sánchez, MP; Sanz, P; Serratosa, JM | 1 |
Chen, CM; Chen, WL; Hsieh-Li, HM; Hsu, KC; Huang, SH; Huang, YJ; Kung, PJ; Lee, GC; Lee-Chen, GJ; Lin, CH; Lin, JY; Tao, YC; Wang, CM; Wu, YR; Yang, JM | 1 |
Duan, W; Guo, Y; Han, H; Hong, K; Li, C; Li, Y; Wang, J; Wang, X; Yu, X | 1 |
Brotchie, JM; He, Q; Koprich, JB; Wang, J; Wang, Y; Xiao, BG; Yu, WB | 1 |
Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; Pedro, JM; Pizarro-Estrella, E; Rodríguez-Arribas, M; Yakhine-Diop, SM | 1 |
Ferguson, SA; Law, CD; Sarkar, S | 1 |
Imaizumi, T; Itoh, K; Maruyama, A; Matsumiya, T; Miki, Y; Mimura, J; Mori, F; Tanji, K; Wakabayashi, K | 1 |
Dong, Z; Duan, H; Ji, X; Jiang, P; Li, M; Li, X; Ma, B; Ma, X; Ni, Z; Wang, B; Wei, Q | 1 |
Bassell, GJ; Deng, Q; Easley, CA; Hales, CM; Holler, CJ; Hu, WT; Hudson, K; Kukar, T; McEachin, ZT; Rossoll, W; Taylor, G; Watkins, WJ | 1 |
Ren, J; Wang, Q | 1 |
Butt, A; Ireland, PM; Korbsrisate, S; Kovacs-Simon, A; Pumirat, P; Sarkar-Tyson, M; Titball, RW; Vanaporn, M | 1 |
Hayashi, C; Igarashi, M; Iijima, K; Iwanami, F; Ohba, S; Sawa, R; Shibuya, Y; Umekita, M; Wada, S | 1 |
Alber, M; Bornemann, S; Deenen, R; DeJesus, MA; Ehrt, S; Hartman, T; Ioerger, TR; Jacobs, WR; Kalscheuer, R; Köhrer, K; Koliwer-Brandl, H; Korte, J; Syson, K; Trujillo, CM | 1 |
Bajaj, L; Bondar, VV; Bremner, L; Chaudhury, A; Cooper, JD; Lotfi, P; Neilson, JR; Nelvagal, HR; Pal, R; Palmieri, M; Pautler, RG; Pereira, FA; Rodney, GG; Saleem, U; Sanagasetti, D; Sardiello, M; Seymour, ML; Stinnett, GR; Tse, DY; Wu, SM | 1 |
Altavilla, D; Bellocco, E; Bitto, A; Fiumara, T; Laganà, G; Magazù, S; Migliardo, F; Minutoli, L; Polito, F; Squadrito, F; Venuti, FS | 1 |
Yang, CR; Yu, RK | 1 |
Chen, W; Lin, Y; Liu, M; Luyckx, J; Qu, J; Ye, Y; Zhang, J; Zhang, X | 1 |
Breger, JA; Chayakulkeeree, M; Daniel, HM; Djordjevic, JT; Himmelreich, U; Krockenberger, MB; Malik, R; Meyer, W; Mylonakis, E; Ngamskulrungroj, P; Perfect, JR; Toffaletti, D; Wilson, C | 1 |
Aigaki, T; Kobayashi, T; Matsuo, T; Tsuda, M | 1 |
Bothner, B; Cramer, RA; Grahl, N; Movahed, N; Paderu, P; Park, S; Perfect, JR; Perlin, DS; Puttikamonkul, S; Willger, SD | 1 |
Casarejos, MJ; de Yébenes, JG; Gomez, A; Mena, MA; Perucho, J; Solano, RM | 1 |
Baudouin, C; Chen, W; Li, J; Liu, G; Roubeix, C; Shi, S; Wang, Y | 1 |
Detweiler, CS; Jorgensen, DR; Nagy, TA; Pilonieta, MC | 1 |
Chung, UI; Echigo, R; Fujisawa, A; Karatsu, K; Kayasuga-Kariya, Y; Kita, Y; Mochizuki, M; Nakamura, M; Ohto, T; Sasaki, N; Shimizu, T; Shimohata, N; Suzuki, S; Yano, F | 1 |
Goedert, M; Lavenir, I; Ozcelik, S; Schaeffer, V; Tolnay, M; Winkler, DT | 1 |
Doi, H; Ikeda, T; Jana, NR; Kurosawa, M; Machida, Y; Nekooki, M; Niu, S; Nukina, N; Tanaka, M | 1 |
Adachi, H; Katsuno, M; Sobue, G | 1 |
Apt, AS; Driscoll, PC; Harris, R; McAlister, MS; Mischenko, VV; Murphy, HN; Robertson, BD; Stewart, GR; Young, DB | 1 |
Machida, Y; Nukina, N; Tanaka, M | 1 |
Ashwell, G; Brodigan, TM; Forsythe, ME; Hanover, JA; Hennessey, PT; Krause, M; Love, DC | 1 |
Berger, Z; Davies, JE; Rubinsztein, DC | 1 |
Altavilla, D; Bellocco, E; Bitto, A; Fiumara, T; Giuliani, D; Guarini, S; Laganà, G; Magazù, S; Minutoli, L; Polito, F; Ruggeri, P; Squadrito, F | 1 |
Argüelles, JC; González-Párraga, P; Martínez-Esparza, M; Pedreño, Y; Sentandreu, R; Valentín, E | 1 |
7 review(s) available for trehalose and Disease Models, Animal
Article | Year |
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The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy.
Topics: alpha-Synuclein; Animals; Autophagy; Brain; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Parkinson Disease; Protein Aggregates; Trehalose | 2021 |
Trehalose in ophthalmology.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Clinical Trials as Topic; Cornea; Disease Models, Animal; Dry Eye Syndromes; Humans; Ophthalmology; Oxidative Stress; Rabbits; Trehalose; Ultraviolet Rays; Wound Healing | 2019 |
Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms.
Topics: Animals; Autophagy; Blood Glucose; Disease Models, Animal; Humans; Metabolic Diseases; Mice; Trehalose | 2019 |
Can trehalose prevent neurodegeneration? Insights from experimental studies.
Topics: Animals; Autophagy; Disease Models, Animal; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Protein Stability; Trehalose | 2014 |
Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?
Topics: Animals; Autophagy; Disease Models, Animal; Food; Humans; Isothiocyanates; Lithium; Neurodegenerative Diseases; Resveratrol; Sirolimus; Spermidine; Stilbenes; Sulfoxides; Trehalose; Valproic Acid | 2015 |
A novel therapeutic strategy for polyglutamine diseases by stabilizing aggregation-prone proteins with small molecules.
Topics: Amyloid; Animals; Disease Models, Animal; Forecasting; Humans; Huntington Disease; Models, Biological; Peptides; Trehalose | 2005 |
Oculopharyngeal muscular dystrophy: potential therapies for an aggregate-associated disorder.
Topics: Animals; Disease Models, Animal; Doxycycline; Humans; Inclusion Bodies; Muscular Dystrophy, Oculopharyngeal; Peptides; Poly(A)-Binding Protein II; Protein Structure, Tertiary; Trehalose; Trinucleotide Repeats | 2006 |
1 trial(s) available for trehalose and Disease Models, Animal
Article | Year |
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Excipients: not so inert? When the excipient plays the role of an active substance, as exemplified by systemic lupus.
Topics: Animals; Autophagy; Disease Models, Animal; Excipients; Humans; Lupus Erythematosus, Systemic; Mice; Peptide Fragments; Trehalose | 2018 |
73 other study(ies) available for trehalose and Disease Models, Animal
Article | Year |
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Restoration of Parkinson's Disease-Like Deficits by Activating Autophagy through mTOR-Dependent and mTOR-Independent Mechanisms in Pharmacological and Transgenic Models of Parkinson's Disease in Mice.
Topics: Adenine; Animals; Autophagy; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Transgenic; MTOR Inhibitors; Neuroinflammatory Diseases; Neuroprotective Agents; Parkinson Disease; Parkinson Disease, Secondary; Signal Transduction; Sirolimus; Substantia Nigra; TOR Serine-Threonine Kinases; Trehalose | 2021 |
Trehalose Reduces Nerve Injury Induced Nociception in Mice but Negatively Affects Alertness.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Maze Learning; Mice; Mice, Inbred C57BL; Nociception; Sciatic Nerve; Trehalose | 2021 |
Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice.
Topics: Animals; Autophagy; Disease Models, Animal; Male; Memory Disorders; Mice; Neuroinflammatory Diseases; Problem Behavior; Trehalose | 2021 |
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; beta-Defensins; Computational Biology; Disease Models, Animal; Female; Gingiva; Inflammation Mediators; Lactobacillus helveticus; Periodontitis; Probiotics; Rats; Rats, Sprague-Dawley; Trehalose | 2022 |
Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Disease Models, Animal; Mice; Mice, Transgenic; Sirolimus; Therapies, Investigational; TOR Serine-Threonine Kinases; Trehalose | 2022 |
Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Olfaction Disorders; Parkinson Disease; Prodromal Symptoms; Rotenone; Trehalose; Tyrosine 3-Monooxygenase | 2022 |
Effect of trehalose on manganese-induced mitochondrial dysfunction and neuronal cell damage in mice.
Topics: Animals; Apoptosis; Autophagy; Behavior, Animal; Disease Models, Animal; Manganese; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Mitophagy; Neurons; Oxidative Stress; Protective Agents; Trehalose | 2019 |
Trehalose protects against spinal cord injury through regulating heat shock proteins 27 and 70 and caspase-3 genes expression.
Topics: Animals; Caspase 3; Disease Models, Animal; Gene Expression; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Locomotion; Male; Neuroprotective Agents; Rats; Rats, Wistar; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Trehalose | 2019 |
Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.
Topics: Aging; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Galactose; Male; Memory Disorders; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Signal Transduction; Trehalose | 2020 |
Trehalose administration in C57BL/6N old mice affects healthspan improving motor learning and brain anti-oxidant defences in a sex-dependent fashion: a pilot study.
Topics: Animals; Antioxidants; Autophagy; Brain; Disease Models, Animal; Female; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Motor Skills; Oxidative Stress; Pilot Projects; Sex Characteristics; Trehalose; Ubiquitinated Proteins | 2020 |
Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice.
Topics: Animals; Bacterial Proteins; Caco-2 Cells; Clostridioides difficile; Clostridium Infections; Diabetes Mellitus; Disaccharidases; Disease Models, Animal; Energy Metabolism; Fasting; Feces; Glucose; HEK293 Cells; Hepatocytes; Humans; Intestinal Mucosa; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Trehalose | 2020 |
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
Topics: Animals; Apoptosis; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Nucleus; Crystallization; Cytokines; Disease Models, Animal; Inflammation; Inflammation Mediators; Lysosomes; Macrophages, Alveolar; Male; Mice, Inbred C57BL; Protein Transport; Pulmonary Fibrosis; Silicon Dioxide; Substrate Specificity; Trehalose | 2020 |
Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Autophagy; Biomarkers; Cells, Cultured; Disease Models, Animal; Inflammation Mediators; Kidney; Male; Mice, Inbred C57BL; Nephritis; Neutrophil Infiltration; Oxidative Stress; Reperfusion Injury; Signal Transduction; Trehalose | 2020 |
Trehalose decreases blood clotting in the cerebral space after experimental subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Blood Coagulation; Disease Models, Animal; Fibrinolysis; Humans; Male; Rabbits; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Trehalose | 2020 |
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.
Topics: Animals; Ataxin-3; Disease Models, Animal; Machado-Joseph Disease; Mice; Mice, Transgenic; Phenotype; Trehalose | 2020 |
CD8
Topics: Animals; CD8-Positive T-Lymphocytes; Clostridiales; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Faecalibacterium prausnitzii; Female; Gastrointestinal Microbiome; Humans; Immunosuppressive Agents; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; RNA, Ribosomal, 16S; Ruminococcus; T-Lymphocytes, Regulatory; Trehalose | 2020 |
Trehalose reduces bone loss in experimental biliary cirrhosis rats via ERK phosphorylation regulation by enhancing autophagosome formation.
Topics: 3T3 Cells; Animals; Autophagosomes; Bone Diseases, Metabolic; Bone Resorption; Cell Differentiation; Disease Models, Animal; Liver Cirrhosis, Biliary; Male; MAP Kinase Signaling System; Mice; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Phosphorylation; RANK Ligand; Rats; Rats, Sprague-Dawley; Signal Transduction; Trehalose | 2020 |
Trehalose Inhibits Aβ Generation and Plaque Formation in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Mice; Mice, Transgenic; Plaque, Amyloid; Trehalose | 2020 |
Trehalose alleviates oxidative stress-mediated liver injury and Mallor-Denk body formation via activating autophagy in mice.
Topics: Administration, Oral; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Disease Models, Animal; Endoplasmic Reticulum Stress; Hepatocytes; Humans; Liver; Liver Diseases; Mallory Bodies; Mice; Oxidative Stress; Pyridines; Trehalose | 2021 |
A diet-induced type 2 diabetes model in Drosophila.
Topics: Animals; Body Weight; Diabetes Mellitus, Type 2; Dietary Sugars; Disease Models, Animal; Drosophila melanogaster; Energy Metabolism; Hemolymph; Humans; Trehalose | 2021 |
An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities.
Topics: Animals; Betacoronavirus 1; Cell Line, Tumor; Coronavirus Infections; Disease Models, Animal; DNA-Binding Proteins; Lysosomes; Male; Mice, Inbred BALB C; Neurodegenerative Diseases; Progranulins; Swine; Trehalose | 2020 |
Trehalose Ameliorates Seizure Susceptibility in Lafora Disease Mouse Models by Suppressing Neuroinflammation and Endoplasmic Reticulum Stress.
Topics: Animals; Autophagy; Brain; Calcium-Binding Proteins; Disease Models, Animal; Disease Susceptibility; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Glucans; Inflammation; Lafora Disease; Membrane Proteins; Mice, Knockout; Microfilament Proteins; Nerve Tissue Proteins; Pentylenetetrazole; Protein Tyrosine Phosphatases, Non-Receptor; Seizures; Trehalose; Ubiquitin-Protein Ligases | 2021 |
Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line; Disease Models, Animal; Epithelial Cells; Fibrosis; Humans; Inflammation Mediators; Interleukin-6; Kidney Tubules; Male; Mice, Inbred C57BL; Nephritis, Interstitial; Rats; Renal Insufficiency, Chronic; Signal Transduction; Trehalose | 2021 |
Role of mass effect and trehalose on early erythrolysis after experimental intracerebral hemorrhage.
Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Erythrocytes; Hematoma; Male; Rats; Rats, Sprague-Dawley; Trehalose | 2022 |
Trehalosomes: Colon targeting trehalose-based green nanocarriers for the maintenance of remission in inflammatory bowel diseases.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Colon; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Design; Inflammation; Inflammatory Bowel Diseases; Oxidative Stress; Plant Extracts; Protective Agents; Rabbits; Trehalose | 2021 |
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Butyric Acid; Disease Models, Animal; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Wistar; Trehalose | 2021 |
Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cognition Disorders; Disease Models, Animal; Green Fluorescent Proteins; Humans; Laser Therapy; Mass Spectrometry; Maze Learning; Metals; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neuroprotective Agents; Presenilin-1; Recombinant Fusion Proteins; Trehalose | 2017 |
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.
Topics: Acute Disease; Animals; Arginine; Autophagy; Bile Acids and Salts; Calcium Signaling; Ceruletide; Choline Deficiency; Cyclophilins; Disease Models, Animal; Endoplasmic Reticulum Stress; Ethionine; Genetic Predisposition to Disease; Humans; Lipid Metabolism; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Proton-Translocating ATPases; Pancreas; Pancreatitis; Peptidyl-Prolyl Isomerase F; Phenotype; Rats; Time Factors; Trehalose | 2018 |
Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.
Topics: Animals; Animals, Newborn; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; Mice, Transgenic; Myocardial Infarction; Rats; Trehalose; Ventricular Remodeling | 2018 |
Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury.
Topics: Animals; Brain; Brain Injuries, Traumatic; Cerebral Cortex; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Trehalose; Zinc | 2018 |
Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose.
Topics: Amyotrophic Lateral Sclerosis; Animals; Autophagy; Cells, Cultured; Disease Models, Animal; Microglia; Neuroprotective Agents; Point Mutation; Rats; Rats, Wistar; Superoxide Dismutase-1; Trehalose; Up-Regulation | 2018 |
Therapeutic activation of autophagy by combined treatment with rapamycin and trehalose in a mouse MPTP-induced model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autophagy; Behavior, Animal; Cognition; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Sirolimus; Substantia Nigra; Trehalose; Tyrosine 3-Monooxygenase | 2019 |
An Ssd1 Homolog Impacts Trehalose and Chitin Biosynthesis and Contributes to Virulence in Aspergillus fumigatus.
Topics: Animals; Aspergillus fumigatus; Cell Wall; Chitin; Disease Models, Animal; Female; Fungal Proteins; Gene Expression Regulation, Fungal; Homeostasis; Host Microbial Interactions; Invasive Pulmonary Aspergillosis; Mice; Mutation; Spores, Fungal; Trehalose; Virulence | 2019 |
Transcription of genes involved in sulfolipid and polyacyltrehalose biosynthesis of Mycobacterium tuberculosis in experimental latent tuberculosis infection.
Topics: Animals; Cell Wall; Chromatography, Thin Layer; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Lipids; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Oxygen; Polyketide Synthases; RNA, Ribosomal, 16S; Trehalose; Tuberculosis, Pulmonary | 2013 |
Trehalose protects against spinal cord ischemia in rabbits.
Topics: Animals; Anterior Horn Cells; Cytoprotection; Disease Models, Animal; Drug Administration Schedule; Infusions, Intra-Arterial; Infusions, Intravenous; Motor Activity; Neuroprotective Agents; Paraparesis; Paraplegia; Rabbits; Spinal Cord; Spinal Cord Injuries; Time Factors; Trehalose | 2014 |
Delineating the relationships among the formation of reactive oxygen species, cell membrane instability and innate autoimmunity in intestinal reperfusion injury.
Topics: Animals; Autoimmunity; Cell Membrane; Disease Models, Animal; Immunity, Innate; Intestinal Mucosa; Ischemia; Male; Mesenteric Ischemia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Superoxide Dismutase-1; Trehalose; Vascular Diseases | 2014 |
MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Autophagy; Cell Survival; Disease Models, Animal; Male; Mice; Mice, Transgenic; Motor Neurons; Spinal Cord; Superoxide Dismutase; TOR Serine-Threonine Kinases; Trehalose | 2014 |
Structure and biological properties of lentztrehalose: a novel trehalose analog.
Topics: Actinobacteria; Animals; Antineoplastic Agents; Bone Density Conservation Agents; Carcinoma, Ehrlich Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; Humans; Mice; Mice, Inbred ICR; Molecular Structure; Non-Nutritive Sweeteners; Osteoporosis, Postmenopausal; Sarcoma 180; Substrate Specificity; Survival Analysis; Trehalase; Trehalose; Tumor Burden; Weight Gain | 2014 |
Quality assessment of platelets stored in a modified platelet additive solution with trehalose at low temperature (10 °C) and in vivo effects on rabbit model of thrombocytopenia.
Topics: Animals; Blood Platelets; Blood Preservation; Disease Models, Animal; Humans; Platelet Transfusion; Plateletpheresis; Quality Assurance, Health Care; Rabbits; Temperature; Thrombocytopenia; Treatment Outcome; Trehalose | 2015 |
Trehalose solution protects mesothelium and reduces bowel adhesions.
Topics: Animals; Cecum; Cell Line; Cytoprotection; Disease Models, Animal; Epithelial Cells; Epithelium; Female; Humans; Hyaluronic Acid; Intestinal Mucosa; Intestines; Isotonic Solutions; Rabbits; Ringer's Solution; Tissue Adhesions; Trehalose | 2014 |
Developmental cell fate and virulence are linked to trehalose homeostasis in Cryptococcus neoformans.
Topics: Adaptation, Physiological; Animals; Cryptococcus neoformans; Disease Models, Animal; Homeostasis; Meningoencephalitis; Mice; Spores, Fungal; Trehalose | 2014 |
Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Protein 7; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Humans; Insulin; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microtubule-Associated Proteins; Models, Molecular; Protein Multimerization; Protein Structure, Quaternary; Recombinant Proteins; Trehalose | 2014 |
Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Encephalitis; Glial Fibrillary Acidic Protein; Glucose Transporter Type 1; Male; Mice; Mice, Inbred C57BL; Microglia; Molecular Chaperones; Nerve Tissue Proteins; Neuroprotective Agents; Parkinsonian Disorders; Trehalose; Tyrosine 3-Monooxygenase; Zonula Occludens-1 Protein | 2014 |
Pharmacological Interventions to Ameliorate Neuropathological Symptoms in a Mouse Model of Lafora Disease.
Topics: Animals; Brain; Disease Models, Animal; Fluorescent Antibody Technique; Gliosis; Glucans; Hippocampus; Inclusion Bodies; Lafora Disease; Metformin; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neuropsychological Tests; Phenylbutyrates; Protein Aggregates; Trehalose; Ubiquitin-Protein Ligases; Ubiquitinated Proteins | 2016 |
The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment.
Topics: Animals; Autophagy; Cell Line; Computer-Aided Design; Digestion; Disease Models, Animal; Drug Design; Drug Stability; Hydrogen Bonding; Hydrolysis; Lactulose; Melibiose; Mice, Transgenic; Molecular Docking Simulation; Molecular Structure; Neurodegenerative Diseases; Neuroprotective Agents; Peptides; Protein Aggregates; Purkinje Cells; Structure-Activity Relationship; TATA-Box Binding Protein; Time Factors; Transfection; Trehalase; Trehalose | 2015 |
Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Autophagy; Body Weight; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Movement Disorders; Neurologic Examination; Statistics, Nonparametric; Superoxide Dismutase; Survival Analysis; Trehalose | 2015 |
Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Autophagy; Behavior, Animal; Blood Glucose; Cattle; Cell Survival; Dependovirus; Disease Models, Animal; Dopaminergic Neurons; Extremities; Female; Humans; Microtubule-Associated Proteins; Parkinson Disease; Rats, Sprague-Dawley; Solubility; Substantia Nigra; Trehalose; Tyrosine 3-Monooxygenase | 2016 |
Chronic MPTP treatment produces hyperactivity in male mice which is not alleviated by concurrent trehalose treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Disease Models, Animal; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Probenecid; Trehalose | 2015 |
Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.
Topics: Administration, Oral; alpha-Synuclein; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Disease Models, Animal; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Lewy Body Disease; Maltose; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Molecular Chaperones; Protein Aggregation, Pathological; Receptors, sigma; Sigma-1 Receptor; Solubility; Trehalose | 2015 |
Effect of Vanadyl Rosiglitazone, a New Insulin-Mimetic Vanadium Complexes, on Glucose Homeostasis of Diabetic Mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Drinking Behavior; Feeding Behavior; Homeostasis; Insulin; Male; Metformin; Mice; Quercetin; Rosiglitazone; Spectrophotometry, Infrared; Thiazolidinediones; Trehalose; Vanadium | 2016 |
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
Topics: Animals; Autophagy; Blotting, Western; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; Frontotemporal Dementia; Gene Expression; Granulins; Haploinsufficiency; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Progranulins; Real-Time Polymerase Chain Reaction; Trehalose; Up-Regulation | 2016 |
mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1.
Topics: Animals; Apoptosis; Autophagy; Calcium Signaling; Cardiotonic Agents; Diabetic Cardiomyopathies; Disease Models, Animal; Enzyme Activation; Forkhead Box Protein O1; Genetic Predisposition to Disease; Insulin Resistance; Mice, Knockout; Myocardial Contraction; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Proto-Oncogene Proteins c-akt; Time Factors; TOR Serine-Threonine Kinases; Trehalose; Ventricular Function, Left | 2016 |
Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts.
Topics: Animals; Biofilms; Burkholderia pseudomallei; Disease Models, Animal; Larva; Macrophages; Melioidosis; Mice; Moths; Sequence Deletion; Stress, Physiological; Temperature; Trehalase; Trehalose; Virulence; Virulence Factors | 2017 |
Stability and Bioavailability of Lentztrehaloses A, B, and C as Replacements for Trehalose.
Topics: Animals; Bacteroides fragilis; Biological Availability; Candida albicans; Cell Line, Tumor; Disease Models, Animal; Enterococcus faecalis; Feces; Female; Humans; Intestinal Mucosa; Intestines; Mice; Mice, Inbred ICR; Micrococcus luteus; Mycobacterium smegmatis; Trehalose | 2016 |
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
Topics: Animals; Bacterial Proteins; Chromatography, Thin Layer; Disease Models, Animal; Female; Gene Expression Profiling; Gene Knockdown Techniques; Glucosyltransferases; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Phosphoric Monoester Hydrolases; Real-Time Polymerase Chain Reaction; Sugar Phosphates; Trehalose; Tuberculosis | 2016 |
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.
Topics: Animals; Astrocytes; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Brain; Cell Nucleus; Disease Models, Animal; Fibroblasts; Gene Knockdown Techniques; HeLa Cells; Heterocyclic Compounds, 3-Ring; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Membrane Glycoproteins; Mice; Mice, Transgenic; Molecular Chaperones; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Phosphorylation; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Signal Transduction; Trehalose | 2017 |
Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock.
Topics: Animals; Anti-Inflammatory Agents; Biophysical Phenomena; Biophysics; Blood Pressure; Cell Membrane; Cytokines; Diffusion; Disease Models, Animal; Edema; I-kappa B Proteins; Lipopolysaccharides; Liver; Liver Diseases; Lung; Lung Diseases; Male; Models, Biological; Neutrons; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Scattering, Radiation; Shock, Septic; Sucrose; Time Factors; Toll-Like Receptor 4; Trehalose; Water | 2008 |
Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease.
Topics: Administration, Oral; Analysis of Variance; Animals; Body Weight; Corpus Striatum; Disease Models, Animal; Hand Strength; Humans; Huntingtin Protein; Huntington Disease; Maze Learning; Mice; Mice, Transgenic; Microarray Analysis; Motor Activity; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Peptides; Psychomotor Performance; Stem Cell Transplantation; Survival Analysis; Trehalose; Trinucleotide Repeat Expansion | 2009 |
Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis.
Topics: Animals; Apoptosis; Conjunctiva; Disease Models, Animal; Drug Evaluation, Preclinical; Dry Eye Syndromes; Epithelium, Corneal; Female; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Ophthalmic Solutions; Tears; Trehalose | 2009 |
The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii.
Topics: Animals; Caenorhabditis elegans; Cryptococcosis; Cryptococcus; Disease Models, Animal; DNA, Fungal; Fungal Proteins; Gene Deletion; Glucosyltransferases; Mice; Mice, Inbred BALB C; Microbial Viability; Molecular Sequence Data; Sequence Analysis, DNA; Trehalose; Virulence | 2009 |
Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Body Weight; Disease Models, Animal; Drosophila; Female; Glucose; Hemolymph; Humans; Insulysin; Male; Neurons; Trehalose | 2010 |
Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.
Topics: Animals; Aspergillus fumigatus; Cell Wall; Culture Media; Disease Models, Animal; Invasive Pulmonary Aspergillosis; Lung; Mice; Mutation; Phosphoric Monoester Hydrolases; Survival Analysis; Trehalose; Virulence | 2010 |
Trehalose protects from aggravation of amyloid pathology induced by isoflurane anesthesia in APP(swe) mutant mice.
Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Disease Models, Animal; Female; Humans; Isoflurane; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Plaque, Amyloid; Treatment Outcome; Trehalose | 2012 |
Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system.
Topics: Animals; Base Sequence; Cornea; Cornified Envelope Proline-Rich Proteins; Cytokines; Disease Models, Animal; DNA Primers; Dry Eye Syndromes; Female; Gene Expression Profiling; HSP70 Heat-Shock Proteins; Immunohistochemistry; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred C57BL; Occludin; Ophthalmic Solutions; Protein Precursors; RNA, Messenger; Trehalose | 2012 |
A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production.
Topics: Animals; Betaine; Disease Models, Animal; Gene Deletion; Hydrogen Peroxide; Hydrogen-Ion Concentration; Macrophages; Membrane Transport Proteins; Mice; Salinity; Salmonella Infections, Animal; Salmonella typhimurium; Salts; Stress, Physiological; Trehalose | 2012 |
Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Hemolysis; Humans; Inflammation; Lipid Peroxidation; Male; Mice; NF-kappa B; Oxidative Stress; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Subarachnoid Hemorrhage; Trehalose; Vasospasm, Intracranial | 2012 |
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy.
Topics: Animals; Autophagy; Brain Stem; Cell Survival; Cerebral Cortex; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Neurons; Spinal Cord; tau Proteins; Tauopathies; Transcription Factor TFIIH; Transcription Factors; Trehalose | 2012 |
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease.
Topics: Animals; Brain; Cell Death; Cell Line; Disease Models, Animal; Glucose; Humans; Huntingtin Protein; Huntington Disease; Liver; Mice; Mice, Transgenic; Motor Activity; Myoglobin; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Peptides; Trehalose | 2004 |
Sweet relief for Huntington disease.
Topics: Animals; Disease Models, Animal; Humans; Huntington Disease; Mice; Mice, Transgenic; Peptides; Trehalose | 2004 |
The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis.
Topics: alpha-Amylases; Animals; Archaeal Proteins; Catalysis; Cell Proliferation; Cell Wall; Disaccharides; Disease Models, Animal; DNA Primers; Glucose; Glucose-6-Phosphate; Glucosyltransferases; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycobacterium tuberculosis; Phosphoric Monoester Hydrolases; Recombinant Proteins; Time Factors; Trehalose; Tuberculosis | 2005 |
A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout.
Topics: Animals; Caenorhabditis elegans; Carmine; Disease Models, Animal; DNA Primers; Fluorescent Antibody Technique; Glycogen; Immunoblotting; Insulin Resistance; Larva; Mutation; N-Acetylglucosaminyltransferases; Oxazines; Polymerase Chain Reaction; Signal Transduction; Trehalose; Triglycerides | 2005 |
The disaccharide trehalose inhibits proinflammatory phenotype activation in macrophages and prevents mortality in experimental septic shock.
Topics: Animals; Disease Models, Animal; Immunophenotyping; Inflammation Mediators; Macrophages; Male; Rats; Rats, Sprague-Dawley; Shock, Septic; Trehalose | 2007 |
Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stress.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Catalase; Disease Models, Animal; Female; Gene Deletion; Glutathione Reductase; Hot Temperature; Hydrogen Peroxide; Hyphae; Mice; Microbial Viability; Morphogenesis; Osmotic Pressure; Oxidative Stress; Superoxide Dismutase; Survival Analysis; Trehalase; Trehalose; Virulence | 2007 |