trazodone has been researched along with Sleep Apnea, Obstructive in 8 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obstructive sleep apnea with comorbid ischemic stroke may be a distinctive phenotype which responds quite well to trazodone, decreasing OSA severity without increasing nocturnal hypoxia." | 9.41 | Trazodone improves obstructive sleep apnea after ischemic stroke: a randomized, double-blind, placebo-controlled, crossover pilot study. ( Chen, CL; Chen, CY; Yu, CC, 2021) |
| "Obstructive sleep apnea (OSA) is a highly prevalent type of sleep-disordered breathing, which is often comorbid with affective disorders such as anxiety." | 5.91 | Successful treatment of auto-trilevel positive airway pressure plus trazodone for obstructive sleep apnea complicated by anxiety disorder: a case report. ( He, X; Lang, Q; Pei, ZM; Yan, HY, 2023) |
| "Obstructive sleep apnea with comorbid ischemic stroke may be a distinctive phenotype which responds quite well to trazodone, decreasing OSA severity without increasing nocturnal hypoxia." | 5.41 | Trazodone improves obstructive sleep apnea after ischemic stroke: a randomized, double-blind, placebo-controlled, crossover pilot study. ( Chen, CL; Chen, CY; Yu, CC, 2021) |
| " Pitolisant, a novel histamine-3 receptor antagonist/inverse agonist, gained approval for the treatment of excessive daytime sleepiness in adults with narcolepsy as well as obstructive sleep apnea." | 5.05 | New pharmacologic agents for insomnia and hypersomnia. ( Earl, DC; Van Tyle, KM, 2020) |
| "Trazodone may increase arousal threshold without compromising upper airway muscles, which should improve OSA." | 2.80 | Trazodone Effects on Obstructive Sleep Apnea and Non-REM Arousal Threshold. ( Deyoung, PN; Edwards, BA; Malhotra, A; McSharry, DG; Orr, JE; Owens, R; Smales, ET; Velasquez, A; Wellman, A, 2015) |
| "Obstructive sleep apnea (OSA) is a highly prevalent type of sleep-disordered breathing, which is often comorbid with affective disorders such as anxiety." | 1.91 | Successful treatment of auto-trilevel positive airway pressure plus trazodone for obstructive sleep apnea complicated by anxiety disorder: a case report. ( He, X; Lang, Q; Pei, ZM; Yan, HY, 2023) |
| "Obstructive sleep apnea hypopnea syndrome (OSAHS) is a prevalent disorder, for which there are no universally effective pharmacotherapeutics." | 1.30 | The effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldog. ( Fenik, P; Hendricks, JC; Pack, AI; Panckeri, K; Veasey, SC, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| He, X | 1 |
| Lang, Q | 1 |
| Pei, ZM | 1 |
| Yan, HY | 1 |
| Earl, DC | 1 |
| Van Tyle, KM | 1 |
| Chen, CY | 1 |
| Chen, CL | 1 |
| Yu, CC | 1 |
| Eckert, DJ | 1 |
| Malhotra, A | 3 |
| Wellman, A | 2 |
| White, DP | 2 |
| Smales, ET | 1 |
| Edwards, BA | 1 |
| Deyoung, PN | 1 |
| McSharry, DG | 1 |
| Velasquez, A | 1 |
| Owens, R | 1 |
| Orr, JE | 1 |
| Brownlow, JA | 1 |
| Harb, GC | 1 |
| Ross, RJ | 1 |
| Heinzer, RC | 1 |
| Jordan, AS | 1 |
| Lo, YL | 1 |
| Dover, L | 1 |
| Stevenson, K | 1 |
| Veasey, SC | 1 |
| Fenik, P | 1 |
| Panckeri, K | 1 |
| Pack, AI | 1 |
| Hendricks, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression[NCT04162743] | Phase 4 | 22 participants (Actual) | Interventional | 2019-02-01 | Completed | ||
| The Effects of Trazodone on the Severity of Obstructive Sleep Apnea[NCT01817907] | 15 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Apnea-Hypopnea Index (AHI) is an index of sleep apnea severity that encompasses the frequency of apneas (cessations in breathing) and hypopneas (reductions in airflow). (NCT01817907)
Timeframe: Participants will be assessed on 2 nights over an average period of 2 weeks.
| Intervention | events/hour (Mean) |
|---|---|
| Placebo | 38.7 |
| Trazodone | 28.5 |
Subjects will have an epiglottic pressure catheter placed during their sleep studies. We will use the swing in the epiglottic pressure trace just prior to arousal to calculate the respiratory drive stimulus that is associated with an a respiratory induced arousal. (NCT01817907)
Timeframe: Participants will be assessed on 2 nights over an average period of 2 weeks.
| Intervention | cmH2O (Mean) |
|---|---|
| Placebo | -19.3 |
| Trazodone | -20.3 |
2 reviews available for trazodone and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
New pharmacologic agents for insomnia and hypersomnia.
Topics: Azepines; Carbamates; Dementia; Disorders of Excessive Somnolence; GABA-A Receptor Agonists; Humans; | 2020 |
Treatment of Sleep Disturbances in Post-Traumatic Stress Disorder: A Review of the Literature.
Topics: Antipsychotic Agents; Cognitive Behavioral Therapy; Dreams; Eye Movement Desensitization Reprocessin | 2015 |
4 trials available for trazodone and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Trazodone improves obstructive sleep apnea after ischemic stroke: a randomized, double-blind, placebo-controlled, crossover pilot study.
Topics: Aged; Blood Pressure Monitoring, Ambulatory; Brain Ischemia; Cross-Over Studies; Double-Blind Method | 2021 |
Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold.
Topics: Adult; Arousal; Continuous Positive Airway Pressure; Cross-Over Studies; Female; Humans; Hypnotics a | 2014 |
Trazodone Effects on Obstructive Sleep Apnea and Non-REM Arousal Threshold.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Continuous Positive Airway Pressure; Cross-Ov | 2015 |
Trazodone increases arousal threshold in obstructive sleep apnoea.
Topics: Adult; Arousal; Female; Humans; Male; Middle Aged; Polysomnography; Sleep Apnea, Obstructive; Sleep | 2008 |
2 other studies available for trazodone and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Successful treatment of auto-trilevel positive airway pressure plus trazodone for obstructive sleep apnea complicated by anxiety disorder: a case report.
Topics: Anxiety; Anxiety Disorders; Female; Humans; Middle Aged; Sleep Apnea Syndromes; Sleep Apnea, Obstruc | 2023 |
The effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldog.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Polysomnography; Respira | 1999 |