trazodone has been researched along with Sensitivity and Specificity in 10 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trazodone is a second-generation antidepressant with serotonin antagonist activity." | 1.35 | HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma. ( Amore, M; Colliva, C; Fanali, S; Mercolini, L; Raggi, MA, 2008) |
| " The developed assay method was applied to a pharmacokinetic study after intravenous injection of apicidin in rats at a dose of 1 mg/kg." | 1.33 | Development of a liquid chromatography/electrospray tandem mass spectrometry assay for the quantification of apicidin, a novel histone deacetylase inhibitor, in rat serum: application to a pharmacokinetic study. ( Han, JW; Kim, CH; Kim, J; Park, EH; Shin, BS; Yoo, SD; Yoon, CH, 2005) |
| " The assay was applied to a pharmacokinetic study in mice to determine dosing schedules that would approximate therapeutic ZD6474 levels determined in humans." | 1.33 | Rapid and sensitive LC/MS/MS analysis of the novel tyrosine kinase inhibitor ZD6474 in mouse plasma and tissues. ( Bradshaw, EL; Gustafson, DL; Long, ME; Zirrolli, JA, 2005) |
| " The present results suggest that brain microdialysis methods may be applicable to pharmacokinetic and pharmacodynamic studies of psychotrophic agents." | 1.30 | Pharmacokinetic and pharmacodynamic analyses of trazodone in rat striatum by in vivo microdialysis. ( Chen, CF; Cheng, FC; Kuo, JS; Tsai, TH; Wu, YS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Olivieri, S | 1 |
| Bovi, G | 1 |
| Petrucci, V | 1 |
| Alfieri, A | 1 |
| Oggianu, L | 1 |
| Picollo, R | 1 |
| Devastato, C | 1 |
| Dragone, P | 1 |
| Garofolo, F | 1 |
| Tongiani, S | 1 |
| Patel, BN | 1 |
| Sharma, N | 1 |
| Sanyal, M | 1 |
| Shrivastav, PS | 1 |
| Sauvage, FL | 1 |
| Picard, N | 1 |
| Saint-Marcoux, F | 1 |
| Gaulier, JM | 1 |
| Lachâtre, G | 1 |
| Marquet, P | 1 |
| Choong, E | 1 |
| Rudaz, S | 1 |
| Kottelat, A | 1 |
| Haldemann, S | 1 |
| Guillarme, D | 1 |
| Veuthey, JL | 1 |
| Eap, CB | 1 |
| Shin, BS | 1 |
| Kim, J | 1 |
| Yoon, CH | 1 |
| Kim, CH | 1 |
| Park, EH | 1 |
| Han, JW | 1 |
| Yoo, SD | 1 |
| Zirrolli, JA | 1 |
| Bradshaw, EL | 1 |
| Long, ME | 1 |
| Gustafson, DL | 1 |
| Kang, X | 1 |
| Pan, C | 1 |
| Xu, Q | 1 |
| Yao, Y | 1 |
| Wang, Y | 1 |
| Qi, D | 1 |
| Gu, Z | 1 |
| Mercolini, L | 1 |
| Colliva, C | 1 |
| Amore, M | 1 |
| Fanali, S | 1 |
| Raggi, MA | 1 |
| Lambert, WE | 1 |
| Van Bocxlaer, JF | 1 |
| De Leenheer, AP | 1 |
| Cheng, FC | 1 |
| Tsai, TH | 1 |
| Wu, YS | 1 |
| Kuo, JS | 1 |
| Chen, CF | 1 |
1 review available for trazodone and Sensitivity and Specificity
| Article | Year |
|---|---|
Potential of high-performance liquid chromatography with photodiode array detection in forensic toxicology.
Topics: Adult; Azides; Chloroquine; Chromatography, High Pressure Liquid; Cocaine; Dothiepin; Female; Forens | 1997 |
9 other studies available for trazodone and Sensitivity and Specificity
| Article | Year |
|---|---|
Juvenile rat and pediatric trazodone studies: how to gain extra sensitivity to overcome bioanalytical challenges.
Topics: Animals; Anti-Anxiety Agents; Blood Specimen Collection; Calibration; Capillaries; Chromatography, L | 2019 |
High throughput and sensitive determination of trazodone and its primary metabolite, m-chlorophenylpiperazine, in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Humans; Piperazines; Sensitivity and Specificity; Tandem Mass Spectrometry; | 2008 |
General unknown screening procedure for the characterization of human drug metabolites in forensic toxicology: applications and constraints.
Topics: Chromatography, High Pressure Liquid; Dibenzothiazepines; Drug Discovery; Forensic Toxicology; Human | 2009 |
Quantification of 4 antidepressants and a metabolite by LC-MS for therapeutic drug monitoring.
Topics: Antidepressive Agents; Bupropion; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stabil | 2011 |
Development of a liquid chromatography/electrospray tandem mass spectrometry assay for the quantification of apicidin, a novel histone deacetylase inhibitor, in rat serum: application to a pharmacokinetic study.
Topics: Animals; Antiprotozoal Agents; Chromatography, High Pressure Liquid; Histone Deacetylase Inhibitors; | 2005 |
Rapid and sensitive LC/MS/MS analysis of the novel tyrosine kinase inhibitor ZD6474 in mouse plasma and tissues.
Topics: Acetates; Animals; Antineoplastic Agents; Calibration; Chemistry, Pharmaceutical; Chromatography; Ch | 2005 |
The investigation of electrospun polymer nanofibers as a solid-phase extraction sorbent for the determination of trazodone in human plasma.
Topics: Absorption; Antidepressive Agents, Second-Generation; Blood Chemical Analysis; Calibration; Chromato | 2007 |
HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma.
Topics: Acetonitriles; Antidepressive Agents; Buffers; Chromatography, High Pressure Liquid; Depression; Dru | 2008 |
Pharmacokinetic and pharmacodynamic analyses of trazodone in rat striatum by in vivo microdialysis.
Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis Solutions; Drug Monitoring; | 1999 |