trazodone has been researched along with Seizures in 16 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thus, it is important to identify the seizure risks associated with antidepressants." | 5.56 | Trazodone increases seizures in a genetic WAG/Rij rat model of absence epilepsy while decreasing them in penicillin-evoked focal seizure model. ( Aygun, H, 2020) |
| "The threshold for seizures is lowered by tramadol." | 2.41 | Lethal combination of tramadol and multiple drugs affecting serotonin. ( Levine, BS; Pestaner, JP; Ripple, MG; Smialek, JE, 2000) |
| "Nomifensine was withdrawn from markets worldwide because of reports of serious hypersensitivity reactions, especially hemolytic anemia, and marketing of bupropion in the United States was delayed after seizures occurred in bulimic patients in clinical trials." | 2.37 | Adverse reactions to five new antidepressants. ( Hayes, PE; Kristoff, CA, 1986) |
| "Clemizole and trazodone were previously identified in a larval zebrafish model for Dravet syndrome." | 1.72 | Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder. ( Baraban, SC; Moog, M, 2022) |
| "Thus, it is important to identify the seizure risks associated with antidepressants." | 1.56 | Trazodone increases seizures in a genetic WAG/Rij rat model of absence epilepsy while decreasing them in penicillin-evoked focal seizure model. ( Aygun, H, 2020) |
| "She was found to have seizure activity without cerebral edema." | 1.51 | Arrhythmias in Severe Trazodone Overdose. ( Lee, MY; Soe, KK, 2019) |
| "The seizure was successfully treated with benzodiazepines." | 1.32 | Seizure secondary to citalopram overdose. ( Cuenca, PJ; Hoefle, JD; Holt, KR, 2004) |
| "Seizures were more common in the amoxapine (24." | 1.27 | Relative toxicity of cyclic antidepressants. ( Gorman, RL; Klein-Schwartz, W; Oderda, GM; Wedin, GP, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Moog, M | 1 |
| Baraban, SC | 1 |
| Aygun, H | 1 |
| Soe, KK | 1 |
| Lee, MY | 1 |
| Waldo, SW | 1 |
| Treit, K | 1 |
| Goldschlager, N | 1 |
| Cuenca, PJ | 1 |
| Holt, KR | 1 |
| Hoefle, JD | 1 |
| Rudorfer, MV | 1 |
| Golden, RN | 2 |
| Potter, WZ | 1 |
| Bowdan, ND | 1 |
| Lanes, T | 1 |
| Ravaris, CL | 1 |
| Ripple, MG | 1 |
| Pestaner, JP | 1 |
| Levine, BS | 1 |
| Smialek, JE | 1 |
| Baughan, E | 1 |
| Jawad, SS | 1 |
| Brown, TM | 1 |
| Miller, H | 1 |
| Evans, DL | 1 |
| Hayes, PE | 1 |
| Kristoff, CA | 1 |
| Flomenbaum, N | 1 |
| Price, D | 1 |
| Wedin, GP | 1 |
| Oderda, GM | 1 |
| Klein-Schwartz, W | 1 |
| Gorman, RL | 1 |
| Dorn, JM | 1 |
| Lefkowitz, D | 1 |
| Kilgo, G | 1 |
| Lee, S | 1 |
4 reviews available for trazodone and Seizures
| Article | Year |
|---|---|
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trial | 1984 |
Lethal combination of tramadol and multiple drugs affecting serotonin.
Topics: Adult; Alcoholism; Analgesics, Opioid; Cyclohexanols; Dibenzothiazepines; Drug Interactions; Fatal O | 2000 |
The new antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Fluoxetine; Maprotiline; Nomifensine; Seizures; Trazod | 1988 |
Adverse reactions to five new antidepressants.
Topics: Acute Kidney Injury; Amoxapine; Animals; Antidepressive Agents; Bupropion; Cardiovascular Diseases; | 1986 |
1 trial available for trazodone and Seizures
| Article | Year |
|---|---|
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trial | 1984 |
12 other studies available for trazodone and Seizures
| Article | Year |
|---|---|
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder.
Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Humans; Larva; Munc18 Proteins; Ra | 2022 |
Trazodone increases seizures in a genetic WAG/Rij rat model of absence epilepsy while decreasing them in penicillin-evoked focal seizure model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, | 2020 |
Arrhythmias in Severe Trazodone Overdose.
Topics: Anti-Anxiety Agents; Anticonvulsants; Bundle-Branch Block; Dopamine; Drug Overdose; Electrocardiogra | 2019 |
Possible acute myocardial infarction in a hypothermic patient.
Topics: Acute Disease; Anticonvulsants; Antimanic Agents; Benzodiazepines; Bipolar Disorder; Drug Overdose; | 2011 |
Seizure secondary to citalopram overdose.
Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Anticonvulsants; Antidepressive Agents, Second-Generation; | 2004 |
Seizure possibly caused by trazodone HCl.
Topics: Adult; Depressive Disorder; Female; Humans; Piperazines; Seizures; Trazodone | 1983 |
Prolonged ECT seizure duration in a patient taking trazodone.
Topics: Aged; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Seizures; Trazodone | 1993 |
Effect of overdose of trazodone.
Topics: Aged; Female; Humans; Hyponatremia; Seizures; Trazodone | 1992 |
Recognition and management of antidepressant overdoses: tricyclics and trazodone.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antidepressive Agents, Tricyclic; Fever; Humans; Hypoten | 1986 |
Relative toxicity of cyclic antidepressants.
Topics: Adolescent; Adult; Aged; Amoxapine; Anthracenes; Antidepressive Agents, Tricyclic; Arrhythmias, Card | 1986 |
A case of phenytoin toxicity possibly precipitated by trazodone.
Topics: Adult; Dizziness; Drug Interactions; Humans; Male; Phenytoin; Schizophrenia, Paranoid; Seizures; Tra | 1986 |
Seizures and trazodone therapy.
Topics: Depressive Disorder; Female; Humans; Middle Aged; Piperazines; Seizures; Trazodone | 1985 |