trazodone has been researched along with Priapism in 41 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Priapism: A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE CELL ANEMIA, advanced malignancy, spinal trauma; and certain drug treatments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine." | 7.68 | Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. ( Bardin, ED; Krieger, JN, 1990) |
| "A case of priapism associated with trazodone is described." | 7.67 | Priapism associated with trazodone therapy: case report. ( Lansky, MR; Selzer, J, 1984) |
| "To investigate the mechanism of drug-induced priapism, we gave the antipsychotic agent chlorpromazine and the antidepressant trazodone to 14 dogs by intravenous and intracorporeal injection." | 7.67 | Priapism induced by chlorpromazine and trazodone: mechanism of action. ( Abber, JC; Juenemann, KP; Lue, TF; Luo, JA; Tanagho, EA, 1987) |
| "The association of priapism with trazodone is reviewed based on data reported to the Food and Drug Administration." | 7.67 | Trazodone and priapism. ( Hollister, LE; Peabody, CA; Warner, MD; Whiteford, HA, 1987) |
| "Priapism is a prolonged erection lasting more than four hours." | 5.91 | [Refractory ischemic priapism due to trazodone]. ( Sempels, M; Vaesen, F, 2023) |
| "Priapism is a urologic disorder and medical emergency with a variety of known etiologies including the use of psychotropic medications." | 5.30 | Priapism following trazodone overdose with cocaine use. ( Henderson, S; Markowitz, JS; Myrick, H, 1998) |
| "Treatment with the antidepressant trazodone has been associated with the occurrence of prolonged penile erection and priapism." | 5.07 | Pathophysiology of prolonged penile erection associated with trazodone use. ( Azadzoi, KM; Blanco, R; Goldstein, I; Krane, RJ; Nadig, PW; Pittard, JT; Saenz de Tejada, I; Ware, JC, 1991) |
| " Trazodone is the drug most commonly associated with the rare but very serious adverse effect of priapism." | 4.83 | Counseling patients about sexual issues. ( Gutierrez, MA; Stimmel, GL, 2006) |
| "From this review, it is concluded that there are very few data to suggest that trazodone improves sleep in patients without mood disorder, though it does increase total sleep in patients with major depressive disorder." | 4.82 | The use of trazodone as a hypnotic: a critical review. ( James, SP; Mendelson, WB, 2004) |
| "We examined whether patients are appropriately screened for previous prolonged erections or priapism and counseled about trazodone complications, specifically prolonged erections and priapism, prior to trazodone treatment." | 4.02 | Pretreatment screening and counseling on prolonged erections for patients prescribed trazodone. ( Deolanker, J; Luu, T; Sadeghi-Nejad, H; Shah, T, 2021) |
| "Our patient presented to the emergency department with priapism, approximately 3 months after beginning a pharmacologic regimen of escitalopram, prazosin, trazodone, and methylphenidate for PTSD." | 3.85 | Recurrent Priapism in a Military Veteran Receiving Treatment for PTSD. ( George, AK; Mann, RA, 2017) |
| "Herein we describe the use of intracavernous methylene blue (MB), a guanylate cyclase inhibitor, or internal pudendal artery embolization for the treatment of priapism." | 3.70 | Alternative approaches to the management of priapism. ( Angle, JF; deHoll, JD; Shin, PA; Steers, WD, 1998) |
| "Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine." | 3.68 | Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. ( Bardin, ED; Krieger, JN, 1990) |
| "A case of priapism associated with trazodone is described." | 3.67 | Priapism associated with trazodone therapy: case report. ( Lansky, MR; Selzer, J, 1984) |
| "As trazodone has been implicated in cardiac disorders, a further search was conducted using the term cardiac and trazodone." | 2.43 | A review of the evidence for the efficacy and safety of trazodone in insomnia. ( Mendelson, WB, 2005) |
| "Nomifensine was withdrawn from markets worldwide because of reports of serious hypersensitivity reactions, especially hemolytic anemia, and marketing of bupropion in the United States was delayed after seizures occurred in bulimic patients in clinical trials." | 2.37 | Adverse reactions to five new antidepressants. ( Hayes, PE; Kristoff, CA, 1986) |
| "Patients with sickle cell anemia or trait and intracavernosal injection-related IP presented sooner than idiopathic cases and those from psychiatric medication (P < ." | 1.62 | Patient Education Is Associated With Reduced Delay to Presentation for Management of Ischemic Priapism: A Retrospective Review of 123 Men. ( Anderson, WB; Cowper, M; Deebel, NA; Dutta, R; Matz, EL; Overholt, TL; Scarberry, KA; Terlecki, RP, 2021) |
| "Priapism is a serious urological and a medical emergency which has often been associated with psychotropic medications (including the antidepressant trazodone), use of marijuana and alcohol, and other factors." | 1.43 | Priapism: What cause: mental illness, psychotropic medications or poly-substance abuse? ( Khan, QS; Lokhande, A; Tucker, P, 2016) |
| "Female priapism is a rare condition that is not commonly described in the literature." | 1.40 | Female clitoral priapism: an over-the-counter option for management. ( Unger, CA; Walters, MD, 2014) |
| "Priapism is a urologic disorder and medical emergency with a variety of known etiologies including the use of psychotropic medications." | 1.30 | Priapism following trazodone overdose with cocaine use. ( Henderson, S; Markowitz, JS; Myrick, H, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (36.59) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 8 (19.51) | 29.6817 |
| 2010's | 6 (14.63) | 24.3611 |
| 2020's | 4 (9.76) | 2.80 |
| Authors | Studies |
|---|---|
| Vaesen, F | 1 |
| Sempels, M | 1 |
| Zhao, H | 1 |
| Berdahl, C | 1 |
| Bresee, C | 1 |
| Moradzadeh, A | 1 |
| Houman, J | 1 |
| Kim, H | 1 |
| Eilber, K | 1 |
| Pevnick, J | 1 |
| Anger, JT | 1 |
| Shah, T | 1 |
| Deolanker, J | 1 |
| Luu, T | 1 |
| Sadeghi-Nejad, H | 1 |
| Dutta, R | 1 |
| Matz, EL | 1 |
| Overholt, TL | 1 |
| Anderson, WB | 1 |
| Deebel, NA | 1 |
| Cowper, M | 1 |
| Terlecki, RP | 1 |
| Scarberry, KA | 1 |
| Matz, A | 1 |
| Ambinder, D | 1 |
| Spencer, E | 1 |
| Phillips, J | 1 |
| Wong, NC | 1 |
| Mann, RA | 1 |
| George, AK | 1 |
| Khan, QS | 1 |
| Tucker, P | 1 |
| Lokhande, A | 1 |
| Unger, CA | 1 |
| Walters, MD | 1 |
| Birur, B | 1 |
| Fargason, RE | 1 |
| Moore, N | 1 |
| Hewett, ML | 1 |
| Kem, DL | 1 |
| Posey, DJ | 1 |
| McDougle, CJ | 1 |
| Brushwood, DB | 1 |
| Kimberlin, CL | 1 |
| James, SP | 1 |
| Mendelson, WB | 2 |
| Wilt, TJ | 1 |
| Fink, HA | 1 |
| du Toit, RM | 1 |
| Millson, RC | 1 |
| Heaton, JP | 1 |
| Adams, MA | 1 |
| Simon, HB | 1 |
| Stimmel, GL | 1 |
| Gutierrez, MA | 1 |
| Aronoff, GM | 1 |
| Scher, M | 1 |
| Krieger, JN | 2 |
| Juergens, S | 1 |
| Lansky, MR | 1 |
| Selzer, J | 1 |
| Thavundayil, JX | 1 |
| Hambalek, R | 1 |
| Kin, NM | 1 |
| Krishnan, B | 1 |
| Lal, S | 1 |
| Balon, R | 1 |
| Pecknold, JC | 1 |
| Langer, SF | 1 |
| deHoll, JD | 1 |
| Shin, PA | 1 |
| Angle, JF | 1 |
| Steers, WD | 1 |
| Myrick, H | 1 |
| Markowitz, JS | 1 |
| Henderson, S | 1 |
| Adaikan, PG | 1 |
| Lau, LC | 1 |
| Vasatha, KS | 1 |
| Susheela, K | 1 |
| Ratnam, SS | 1 |
| Saenz de Tejada, I | 1 |
| Ware, JC | 1 |
| Blanco, R | 1 |
| Pittard, JT | 1 |
| Nadig, PW | 1 |
| Azadzoi, KM | 1 |
| Krane, RJ | 1 |
| Goldstein, I | 1 |
| Bardin, ED | 1 |
| Fishbain, DA | 1 |
| Hayes, PE | 1 |
| Kristoff, CA | 1 |
| Carson, CC | 1 |
| Mino, RD | 1 |
| Hanno, PM | 1 |
| Lopez, R | 1 |
| Wein, AJ | 1 |
| Abber, JC | 1 |
| Lue, TF | 1 |
| Luo, JA | 1 |
| Juenemann, KP | 1 |
| Tanagho, EA | 1 |
| Warner, MD | 1 |
| Peabody, CA | 1 |
| Whiteford, HA | 1 |
| Hollister, LE | 1 |
| Benkelfat, C | 1 |
| Gay, C | 1 |
| Renardet, M | 1 |
| Raskin, DE | 1 |
| Sacks, M | 1 |
| Miller, F | 1 |
| Gunn, J | 1 |
| Paul, E | 1 |
| Sellew, A | 1 |
| Patt, N | 1 |
4 reviews available for trazodone and Priapism
| Article | Year |
|---|---|
The use of trazodone as a hypnotic: a critical review.
Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Comorbidity; Depressive Disorder; Humans; Hypn | 2004 |
A review of the evidence for the efficacy and safety of trazodone in insomnia.
Topics: Adult; Age Factors; Aged; Antidepressive Agents, Second-Generation; Clinical Trials as Topic; Depres | 2005 |
Counseling patients about sexual issues.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Antidepressive Agents; Counseling; Cyclic Nucleotide Phosphodie | 2006 |
Adverse reactions to five new antidepressants.
Topics: Acute Kidney Injury; Amoxapine; Animals; Antidepressive Agents; Bupropion; Cardiovascular Diseases; | 1986 |
1 trial available for trazodone and Priapism
| Article | Year |
|---|---|
Pathophysiology of prolonged penile erection associated with trazodone use.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Humans; In Vitro Technique | 1991 |
36 other studies available for trazodone and Priapism
| Article | Year |
|---|---|
[Refractory ischemic priapism due to trazodone].
Topics: Adult; Humans; Male; Penile Erection; Penis; Priapism; Trazodone | 2023 |
Priapism from Recreational Intracavernosal Injections in a High-Risk Metropolitan Community.
Topics: Adult; Emergency Service, Hospital; Erectile Dysfunction; Humans; Illicit Drugs; Injections; Los Ang | 2019 |
Pretreatment screening and counseling on prolonged erections for patients prescribed trazodone.
Topics: Adult; Antidepressive Agents, Second-Generation; Directive Counseling; Humans; Male; Mass Screening; | 2021 |
Patient Education Is Associated With Reduced Delay to Presentation for Management of Ischemic Priapism: A Retrospective Review of 123 Men.
Topics: Anemia, Sickle Cell; Humans; Male; Patient Education as Topic; Priapism; Retrospective Studies; Traz | 2021 |
Review of Priapism Litigation in the United States.
Topics: Erectile Dysfunction; Humans; Insurance Claim Review; Male; Malpractice; Priapism; Psychotropic Drug | 2021 |
Recurrent Priapism in a Military Veteran Receiving Treatment for PTSD.
Topics: Adult; Citalopram; Humans; Male; Methylphenidate; Prazosin; Priapism; Psychotropic Drugs; Stress Dis | 2017 |
Priapism: What cause: mental illness, psychotropic medications or poly-substance abuse?
Topics: Adrenergic alpha-1 Receptor Antagonists; Depressive Disorder, Major; Hepatitis C; Humans; Male; Midd | 2016 |
Female clitoral priapism: an over-the-counter option for management.
Topics: Adult; Bupropion; Clitoris; Female; Humans; Male; Nonprescription Drugs; Pain; Priapism; Pseudoephed | 2014 |
Delayed-onset of psychopharmacologically induced priapism: A cautionary case report.
Topics: Adult; Antipsychotic Agents; Drug Interactions; Drug Substitution; Drug-Related Side Effects and Adv | 2015 |
What is causing this patient's priapism?
Topics: Anti-Anxiety Agents; Humans; Male; Middle Aged; Priapism; Trazodone | 2015 |
Priapism associated with trazodone in an adolescent with autism.
Topics: Adolescent; Autistic Disorder; Depressive Disorder; Humans; Male; Priapism; Selective Serotonin Reup | 2002 |
Voluntary undertaking rule and duty to warn.
Topics: Duty to Warn; Erectile Dysfunction; Humans; Male; Patient Education as Topic; Pharmacists; Postopera | 2002 |
Is antidepressant plus sildenafil a recipe for priapism?
Topics: Antidepressive Agents; Drug Therapy, Combination; Erectile Dysfunction; Humans; Male; Phosphodiester | 2004 |
Priapism.
Topics: Adult; Dibenzothiazepines; Drug Therapy, Combination; Humans; Male; Priapism; Quetiapine Fumarate; R | 2004 |
On call. I am 47 years old and I've always been healthy. My main problem is insomnia. Sleeping pills don't work well, and they make me feel groggy. Finally, my doctor gave me a prescription for Desyrel, and he seems to have hit the bull's-eye. I've been s
Topics: Antidepressive Agents, Second-Generation; Humans; Male; Priapism; Sleep Initiation and Maintenance D | 2006 |
Trazodone associated with priapism.
Topics: Depression; Humans; Male; Piperazines; Priapism; Trazodone | 1984 |
Antidepressant side effects.
Topics: Antidepressive Agents, Tricyclic; Female; Humans; Male; Piperazines; Priapism; Prolactin; Trazodone | 1984 |
Trazodone and priapism.
Topics: Combined Modality Therapy; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Male; Midd | 1983 |
Priapism with trazodone (Desyrel).
Topics: Adult; Erectile Dysfunction; Humans; Male; Middle Aged; Penis; Piperazines; Priapism; Trazodone | 1984 |
Priapism associated with trazodone therapy: case report.
Topics: Adult; Depressive Disorder; Humans; Male; Piperazines; Priapism; Trazodone | 1984 |
Prolonged penile erections induced by hydroxyzine: possible mechanism of action.
Topics: Adult; Humans; Hydroxyzine; Insect Bites and Stings; Male; Models, Molecular; Molecular Conformation | 1994 |
Fluoxetine-induced sexual dysfunction and yohimbine.
Topics: Drug Therapy, Combination; Fluoxetine; Humans; Male; Penile Erection; Priapism; Sexual Dysfunctions, | 1993 |
Priapism: trazodone versus nefazodone.
Topics: Antidepressive Agents, Second-Generation; Depressive Disorder; Humans; Male; Middle Aged; Piperazine | 1996 |
Alternative approaches to the management of priapism.
Topics: Adult; Alprostadil; Anemia, Sickle Cell; Embolization, Therapeutic; Enzyme Inhibitors; Guanylate Cyc | 1998 |
Priapism following trazodone overdose with cocaine use.
Topics: Adult; Cardiovascular Agents; Cocaine; Cocaine-Related Disorders; Drug Interactions; Drug Overdose; | 1998 |
[Neurotransmitters of penile erection other than vasoactive intestinal polypeptide. Physiologic data and therapeutic consequences].
Topics: Alprostadil; Erectile Dysfunction; Humans; Male; Neurotransmitter Agents; Papaverine; Penile Erectio | 1990 |
Pharmacological priapism: comparison of trazodone- and papaverine-associated cases.
Topics: Depressive Disorder; Erectile Dysfunction; Humans; Male; Papaverine; Priapism; Trazodone | 1990 |
Re: Priapism associated with trazodone therapy.
Topics: Humans; Male; Parasympatholytics; Priapism; Trazodone | 1989 |
Priapism associated with trazodone therapy.
Topics: Adult; Humans; Male; Priapism; Trazodone | 1988 |
Trazodone-induced priapism.
Topics: Adult; Humans; Male; Priapism; Trazodone | 1988 |
Priapism induced by chlorpromazine and trazodone: mechanism of action.
Topics: Animals; Chlorpromazine; Dogs; Male; Penile Erection; Penis; Priapism; Regional Blood Flow; Trazodon | 1987 |
Trazodone and priapism.
Topics: Adolescent; Adult; Age Factors; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Priapis | 1987 |
Use of interactive computer technology in open clinical trials. Study with trazodone in depressed patients.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Computers; Depressive Disorder; Dizziness; Female | 1986 |
Trazodone and priapism.
Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Male; Piperazines; Priapism; T | 1985 |
Unusual erectile activity as a side effect of trazodone.
Topics: Depressive Disorder; Humans; Male; Middle Aged; Piperazines; Priapism; Trazodone | 1985 |
More on trazodone and priapism.
Topics: Depressive Disorder; Humans; Male; Middle Aged; Piperazines; Priapism; Trazodone | 1985 |