trazodone has been researched along with Pregnancy in 14 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective single-blind study was conducted to compare flunitrazepam vs trazodone in the premedication of patients undergoing day-case surgery for termination of pregnancy, with particular regard to the degree of preoperative sedation, intraoperative analgesia and postoperative recovery." | 5.07 | [Trazodone versus flunitrazepam in premedication in day-care surgery]. ( Andriolli, A; Bonazzi, M; Laveneziana, D; Marsicano, M; Prampolini, F; Riva, A; Speranza, R, 1994) |
| " One drug, trazodone, caused arrhythmia consistent with blockade of the hERG (human ether-a-go-go related gene) potassium channel." | 3.78 | Antidepressants cause bradycardia and heart block in GD 13 rat embryos in vitro. ( Ababneh, D; Ritchie, H; Webster, WS, 2012) |
| "Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment." | 2.78 | Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial. ( Emamian, F; Ghadami, MR; Khazaie, H; Knight, DC; Tahmasian, M, 2013) |
| "Preeclampsia is a pregnancy-related condition that causes high blood pressure and proteinuria after 20 weeks of pregnancy." | 1.72 | Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications. ( Gao, N; Hong, H; Ma, Y; Peng, Y; Wan, A, 2022) |
| "Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia." | 1.62 | Trazodone effects on developing brain. ( Allen, LB; Anderson, A; Genaro-Mattos, TC; Korade, Z; Mirnics, K; Porter, NA; Tallman, KA, 2021) |
| "Trazodone was tested for its ability to elevate serum prolactin levels in mature female rats." | 1.27 | Effects of acute and chronic trazodone administration on serum prolactin levels in adult female rats. ( Fernstrom, JD; Fernstrom, MH; Van Itallie, CM, 1983) |
| "Etoperidone was administered to pregnant rats and rabbits during the period of organogenesis." | 1.26 | Teratological study of etoperidone in the rat and rabbit. ( Barcellona, PS; Campana, A; Fanelli, O, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, Y | 1 |
| Hong, H | 1 |
| Gao, N | 1 |
| Wan, A | 1 |
| Ma, Y | 1 |
| Korade, Z | 1 |
| Allen, LB | 1 |
| Anderson, A | 1 |
| Tallman, KA | 1 |
| Genaro-Mattos, TC | 1 |
| Porter, NA | 1 |
| Mirnics, K | 1 |
| Khazaie, H | 1 |
| Ghadami, MR | 1 |
| Knight, DC | 1 |
| Emamian, F | 1 |
| Tahmasian, M | 1 |
| Nigmatullina, RR | 1 |
| Matveeva, VL | 1 |
| Chibireva, MD | 1 |
| Ababneh, D | 1 |
| Ritchie, H | 1 |
| Webster, WS | 1 |
| Einarson, A | 1 |
| Bonari, L | 1 |
| Voyer-Lavigne, S | 1 |
| Addis, A | 1 |
| Matsui, D | 1 |
| Johnson, Y | 1 |
| Koren, G | 1 |
| Hsiao, SY | 1 |
| Cherng, CF | 1 |
| Yang, YK | 1 |
| Yeh, TL | 1 |
| Yu, L | 1 |
| Klier, CM | 1 |
| Mossaheb, N | 1 |
| Saria, A | 1 |
| Schloegelhofer, M | 1 |
| Zernig, G | 1 |
| Fernstrom, JD | 1 |
| Van Itallie, CM | 1 |
| Fernstrom, MH | 1 |
| Nastri, D | 1 |
| Amatruda, G | 1 |
| Della Corte, V | 1 |
| Di Vito, A | 1 |
| Iannizzaro, W | 1 |
| Bonazzi, M | 1 |
| Riva, A | 1 |
| Marsicano, M | 1 |
| Prampolini, F | 1 |
| Speranza, R | 1 |
| Andriolli, A | 1 |
| Laveneziana, D | 1 |
| Barcellona, PS | 1 |
| Fanelli, O | 1 |
| Campana, A | 1 |
| Mazzi, C | 1 |
| Montanini, R | 1 |
| Riva, LP | 1 |
| Verbeeck, RK | 1 |
| Ross, SG | 1 |
| McKenna, EA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT05753943] | 0 participants | Expanded Access | No longer available | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for trazodone and Pregnancy
| Article | Year |
|---|---|
Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial.
Topics: Actigraphy; Adult; Antidepressive Agents, Second-Generation; Depression; Depression, Postpartum; Dip | 2013 |
A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy.
Topics: Antidepressive Agents, Second-Generation; Female; Follow-Up Studies; Humans; Piperazines; Pregnancy; | 2003 |
[Trazodone versus flunitrazepam in premedication in day-care surgery].
Topics: Abortion, Induced; Adolescent; Adult; Ambulatory Surgical Procedures; Analgesia; Anesthesia Recovery | 1994 |
11 other studies available for trazodone and Pregnancy
| Article | Year |
|---|---|
Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications.
Topics: Biomarkers; Chemokines; Computational Biology; Dexamethasone; Female; Gene Expression Profiling; Hum | 2022 |
Trazodone effects on developing brain.
Topics: Brain; Child; Cholesterol; Female; Humans; Infant, Newborn; Maternal Exposure; Oxidoreductases Actin | 2021 |
[The influence of selective serotonin re-uptake inhibitor fluoxetine on inotropic function of myocardium in the ontogenesis of rats].
Topics: Age Factors; Animals; Animals, Newborn; Cardiotonic Agents; Dose-Response Relationship, Drug; Female | 2014 |
Antidepressants cause bradycardia and heart block in GD 13 rat embryos in vitro.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Bradycardia; Calcium Channels; Female; Heart; | 2012 |
Prenatal bupropion exposure enhances the cocaine reward and stress susceptibility in adult mice.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Bupropion; Citalopram; Cocaine; Conditio | 2005 |
Pharmacokinetics and elimination of quetiapine, venlafaxine, and trazodone during pregnancy and postpartum.
Topics: Adolescent; Antipsychotic Agents; Bipolar Disorder; Cyclohexanols; Dibenzothiazepines; Female; Human | 2007 |
Effects of acute and chronic trazodone administration on serum prolactin levels in adult female rats.
Topics: Animals; Diestrus; Dose-Response Relationship, Drug; Estrus; Female; Piperazines; Pregnancy; Proestr | 1983 |
[Propanidid and trazodone in ultrashort anesthesia].
Topics: Adult; Aged; Anesthesia; Anesthesia, Obstetrical; Female; Humans; Middle Aged; Minor Surgical Proced | 1980 |
Teratological study of etoperidone in the rat and rabbit.
Topics: Animals; Behavior, Animal; Body Weight; Female; Fetal Death; Fetus; Maternal-Fetal Exchange; Piperaz | 1977 |
[Action of trazodone on the secretion of pituitary hormones. Behavior of prolactin and somatotropin].
Topics: Acromegaly; Adenoma; Adult; Amenorrhea; Female; Galactorrhea; Growth Hormone; Humans; Lactation Diso | 1979 |
Excretion of trazodone in breast milk.
Topics: Adult; Female; Humans; Kinetics; Lactation; Milk, Human; Pregnancy; Trazodone | 1986 |