Page last updated: 2024-11-05

trazodone and Pregnancy

trazodone has been researched along with Pregnancy in 14 studies

Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"A prospective single-blind study was conducted to compare flunitrazepam vs trazodone in the premedication of patients undergoing day-case surgery for termination of pregnancy, with particular regard to the degree of preoperative sedation, intraoperative analgesia and postoperative recovery."5.07[Trazodone versus flunitrazepam in premedication in day-care surgery]. ( Andriolli, A; Bonazzi, M; Laveneziana, D; Marsicano, M; Prampolini, F; Riva, A; Speranza, R, 1994)
" One drug, trazodone, caused arrhythmia consistent with blockade of the hERG (human ether-a-go-go related gene) potassium channel."3.78Antidepressants cause bradycardia and heart block in GD 13 rat embryos in vitro. ( Ababneh, D; Ritchie, H; Webster, WS, 2012)
"Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment."2.78Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial. ( Emamian, F; Ghadami, MR; Khazaie, H; Knight, DC; Tahmasian, M, 2013)
"Preeclampsia is a pregnancy-related condition that causes high blood pressure and proteinuria after 20 weeks of pregnancy."1.72Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications. ( Gao, N; Hong, H; Ma, Y; Peng, Y; Wan, A, 2022)
"Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia."1.62Trazodone effects on developing brain. ( Allen, LB; Anderson, A; Genaro-Mattos, TC; Korade, Z; Mirnics, K; Porter, NA; Tallman, KA, 2021)
"Trazodone was tested for its ability to elevate serum prolactin levels in mature female rats."1.27Effects of acute and chronic trazodone administration on serum prolactin levels in adult female rats. ( Fernstrom, JD; Fernstrom, MH; Van Itallie, CM, 1983)
"Etoperidone was administered to pregnant rats and rabbits during the period of organogenesis."1.26Teratological study of etoperidone in the rat and rabbit. ( Barcellona, PS; Campana, A; Fanelli, O, 1977)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19905 (35.71)18.7374
1990's1 (7.14)18.2507
2000's3 (21.43)29.6817
2010's3 (21.43)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Peng, Y1
Hong, H1
Gao, N1
Wan, A1
Ma, Y1
Korade, Z1
Allen, LB1
Anderson, A1
Tallman, KA1
Genaro-Mattos, TC1
Porter, NA1
Mirnics, K1
Khazaie, H1
Ghadami, MR1
Knight, DC1
Emamian, F1
Tahmasian, M1
Nigmatullina, RR1
Matveeva, VL1
Chibireva, MD1
Ababneh, D1
Ritchie, H1
Webster, WS1
Einarson, A1
Bonari, L1
Voyer-Lavigne, S1
Addis, A1
Matsui, D1
Johnson, Y1
Koren, G1
Hsiao, SY1
Cherng, CF1
Yang, YK1
Yeh, TL1
Yu, L1
Klier, CM1
Mossaheb, N1
Saria, A1
Schloegelhofer, M1
Zernig, G1
Fernstrom, JD1
Van Itallie, CM1
Fernstrom, MH1
Nastri, D1
Amatruda, G1
Della Corte, V1
Di Vito, A1
Iannizzaro, W1
Bonazzi, M1
Riva, A1
Marsicano, M1
Prampolini, F1
Speranza, R1
Andriolli, A1
Laveneziana, D1
Barcellona, PS1
Fanelli, O1
Campana, A1
Mazzi, C1
Montanini, R1
Riva, LP1
Verbeeck, RK1
Ross, SG1
McKenna, EA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT05753943]0 participants Expanded AccessNo longer available
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for trazodone and Pregnancy

ArticleYear
Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial.
    Psychiatry research, 2013, Dec-30, Volume: 210, Issue:3

    Topics: Actigraphy; Adult; Antidepressive Agents, Second-Generation; Depression; Depression, Postpartum; Dip

2013
A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2003, Volume: 48, Issue:2

    Topics: Antidepressive Agents, Second-Generation; Female; Follow-Up Studies; Humans; Piperazines; Pregnancy;

2003
[Trazodone versus flunitrazepam in premedication in day-care surgery].
    Minerva anestesiologica, 1994, Volume: 60, Issue:3

    Topics: Abortion, Induced; Adolescent; Adult; Ambulatory Surgical Procedures; Analgesia; Anesthesia Recovery

1994

Other Studies

11 other studies available for trazodone and Pregnancy

ArticleYear
Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications.
    BMC genomics, 2022, Oct-19, Volume: 23, Issue:1

    Topics: Biomarkers; Chemokines; Computational Biology; Dexamethasone; Female; Gene Expression Profiling; Hum

2022
Trazodone effects on developing brain.
    Translational psychiatry, 2021, 02-01, Volume: 11, Issue:1

    Topics: Brain; Child; Cholesterol; Female; Humans; Infant, Newborn; Maternal Exposure; Oxidoreductases Actin

2021
[The influence of selective serotonin re-uptake inhibitor fluoxetine on inotropic function of myocardium in the ontogenesis of rats].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2014, Volume: 100, Issue:3

    Topics: Age Factors; Animals; Animals, Newborn; Cardiotonic Agents; Dose-Response Relationship, Drug; Female

2014
Antidepressants cause bradycardia and heart block in GD 13 rat embryos in vitro.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2012, Volume: 95, Issue:2

    Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Bradycardia; Calcium Channels; Female; Heart;

2012
Prenatal bupropion exposure enhances the cocaine reward and stress susceptibility in adult mice.
    The Chinese journal of physiology, 2005, Dec-31, Volume: 48, Issue:4

    Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Bupropion; Citalopram; Cocaine; Conditio

2005
Pharmacokinetics and elimination of quetiapine, venlafaxine, and trazodone during pregnancy and postpartum.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6

    Topics: Adolescent; Antipsychotic Agents; Bipolar Disorder; Cyclohexanols; Dibenzothiazepines; Female; Human

2007
Effects of acute and chronic trazodone administration on serum prolactin levels in adult female rats.
    Life sciences, 1983, Dec-19, Volume: 33, Issue:25

    Topics: Animals; Diestrus; Dose-Response Relationship, Drug; Estrus; Female; Piperazines; Pregnancy; Proestr

1983
[Propanidid and trazodone in ultrashort anesthesia].
    Minerva anestesiologica, 1980, Volume: 46, Issue:4

    Topics: Adult; Aged; Anesthesia; Anesthesia, Obstetrical; Female; Humans; Middle Aged; Minor Surgical Proced

1980
Teratological study of etoperidone in the rat and rabbit.
    Toxicology, 1977, Volume: 8, Issue:1

    Topics: Animals; Behavior, Animal; Body Weight; Female; Fetal Death; Fetus; Maternal-Fetal Exchange; Piperaz

1977
[Action of trazodone on the secretion of pituitary hormones. Behavior of prolactin and somatotropin].
    Minerva medica, 1979, Mar-17, Volume: 70, Issue:13

    Topics: Acromegaly; Adenoma; Adult; Amenorrhea; Female; Galactorrhea; Growth Hormone; Humans; Lactation Diso

1979
Excretion of trazodone in breast milk.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:3

    Topics: Adult; Female; Humans; Kinetics; Lactation; Milk, Human; Pregnancy; Trazodone

1986