trazodone has been researched along with Long QT Syndrome in 8 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A dose-response relationship was identified for level of care and medical outcome." | 1.72 | Single-substance trazodone exposures reported to US poison centers from 2000 to 2019. ( Husak, N; Klein-Schwartz, W; Leonard, JB; Seung, H, 2022) |
| "She was found to have seizure activity without cerebral edema." | 1.51 | Arrhythmias in Severe Trazodone Overdose. ( Lee, MY; Soe, KK, 2019) |
| "Trazodone has been associated with prolonged QT-interval and increased risk of polymorphous ventricular tachycardias clinically and has demonstrated in vitro inhibition of hERG (human ether-รก-go-go-related gene) channel current." | 1.33 | Effect of trazodone on hERG channel current and QT-interval. ( Appleton, N; Lansdell, K; Tarantino, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Husak, N | 1 |
| Leonard, JB | 1 |
| Seung, H | 1 |
| Klein-Schwartz, W | 1 |
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Soe, KK | 1 |
| Lee, MY | 1 |
| Tellone, V | 1 |
| Rosignoli, MT | 1 |
| Picollo, R | 1 |
| Dragone, P | 1 |
| Del Vecchio, A | 1 |
| Comandini, A | 1 |
| Radicioni, M | 1 |
| Leuratti, C | 1 |
| Calisti, F | 1 |
| Tarantino, P | 1 |
| Appleton, N | 1 |
| Lansdell, K | 1 |
| Dattilo, PB | 1 |
| Nordin, C | 1 |
| Service, JA | 1 |
| Waring, WS | 1 |
| Levenson, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Single Centre, Single Dose, Randomised, Negative and Positive-controlled, Double-blind Trazodone vs. Negative Control (Placebo), Open-label vs. Positive Control (Moxifloxacin), 5-way Cross-over QT/QTc Study[NCT03516630] | Phase 1 | 20 participants (Actual) | Interventional | 2017-03-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for trazodone and Long QT Syndrome
| Article | Year |
|---|---|
Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Antidepressive Agents, Second-Generation; Cross- | 2020 |
7 other studies available for trazodone and Long QT Syndrome
| Article | Year |
|---|---|
Single-substance trazodone exposures reported to US poison centers from 2000 to 2019.
Topics: Databases, Factual; Humans; Long QT Syndrome; Poison Control Centers; Poisons; Retrospective Studies | 2022 |
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
Arrhythmias in Severe Trazodone Overdose.
Topics: Anti-Anxiety Agents; Anticonvulsants; Bundle-Branch Block; Dopamine; Drug Overdose; Electrocardiogra | 2019 |
Effect of trazodone on hERG channel current and QT-interval.
Topics: Action Potentials; Animals; Cell Line; Cisapride; Dose-Response Relationship, Drug; ERG1 Potassium C | 2005 |
Prolonged QT associated with an overdose of trazodone.
Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Depression; Drug Overdose; Electrocardio | 2007 |
QT Prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone.
Topics: Adult; Antidepressive Agents, Second-Generation; Atrioventricular Node; Drug Overdose; Electrocardio | 2008 |
Prolonged QT interval after trazodone overdose.
Topics: Adult; Charcoal; Drug Overdose; Electrocardiography; Female; Gastric Lavage; Humans; Long QT Syndrom | 1999 |