trazodone has been researched along with Innate Inflammatory Response in 6 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings supported the protective effects of l-carnitine on rat testes due to suppression of oxidative stress, inflammation and enhancing autophagy." | 8.12 | l-carnitine modulates autophagy, oxidative stress and inflammation in trazodone induced testicular toxicity. ( Khedr, NF; Werida, RH, 2022) |
| "These findings supported the protective effects of l-carnitine on rat testes due to suppression of oxidative stress, inflammation and enhancing autophagy." | 4.12 | l-carnitine modulates autophagy, oxidative stress and inflammation in trazodone induced testicular toxicity. ( Khedr, NF; Werida, RH, 2022) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| "The anti-inflammatory activity of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), was studied on the carrageenan-induced paw inflammation in the rat." | 3.72 | Studies on the anti-inflammatory effect of fluoxetine in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR, 2004) |
| "Trazodone is a drug that was introduced in the clinic almost 40 years ago." | 1.48 | Evaluating the dose-dependent mechanism of action of trazodone by estimation of occupancies for different brain neurotransmitter targets. ( Settimo, L; Taylor, D, 2018) |
| "Trazodone (TDZ) is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors." | 1.42 | Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK. ( Da Pozzo, E; Daniele, S; Martini, C; Zappelli, E, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Khedr, NF | 1 |
| Werida, RH | 1 |
| Settimo, L | 1 |
| Taylor, D | 1 |
| Daniele, S | 1 |
| Da Pozzo, E | 1 |
| Zappelli, E | 1 |
| Martini, C | 1 |
| Abdel-Salam, OM | 2 |
| Nofal, SM | 1 |
| El-Shenawy, SM | 1 |
| Baiuomy, AR | 1 |
| Arbid, MS | 1 |
| Irvin, W | 1 |
| MacDonald, G | 1 |
| Smith, JK | 1 |
| Kim, WY | 1 |
6 other studies available for trazodone and Innate Inflammatory Response
| Article | Year |
|---|---|
l-carnitine modulates autophagy, oxidative stress and inflammation in trazodone induced testicular toxicity.
Topics: Animals; Antioxidants; Autophagy; Carnitine; Inflammation; Lipid Peroxidation; Male; Oxidative Stres | 2022 |
Evaluating the dose-dependent mechanism of action of trazodone by estimation of occupancies for different brain neurotransmitter targets.
Topics: Animals; Antidepressive Agents; Brain; Dementia; Depression; Depressive Disorder; Humans; Hypnotics | 2018 |
Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK.
Topics: Anti-Inflammatory Agents; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Line; Cell Proliferatio | 2015 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
Studies on the anti-inflammatory effect of fluoxetine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyc | 2004 |
Dexamethasone-induced posterior reversible encephalopathy syndrome.
Topics: Anti-Inflammatory Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Dexamethasone; Dopamine A | 2007 |