Page last updated: 2024-11-05

trazodone and Fibromyalgia

trazodone has been researched along with Fibromyalgia in 3 studies

Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.

Fibromyalgia: A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)

Research Excerpts

ExcerptRelevanceReference
"Treatment with trazodone significantly improved global fibromyalgia severity, sleep quality, and depression, as well as pain interference with daily activities although without showing a direct effect on bodily pain."9.15Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study. ( Calandre, EP; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM, 2011)
"Despite its frequent use as a hypnotic, trazodone has not been systematically assessed in fibromyalgia patients."9.14Trazodone for the treatment of fibromyalgia: an open-label, 12-week study. ( Calandre, EP; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM, 2010)
"Treatment with trazodone significantly improved global fibromyalgia severity, sleep quality, and depression, as well as pain interference with daily activities although without showing a direct effect on bodily pain."5.15Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study. ( Calandre, EP; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM, 2011)
"Despite its frequent use as a hypnotic, trazodone has not been systematically assessed in fibromyalgia patients."5.14Trazodone for the treatment of fibromyalgia: an open-label, 12-week study. ( Calandre, EP; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM, 2010)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morillas-Arques, P2
Rodriguez-Lopez, CM2
Molina-Barea, R2
Rico-Villademoros, F2
Calandre, EP2
Bellometti, S1
Galzigna, L1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Open Label Trial Concerning the Effectiveness of Trazodone in the Treatment of Fibromyalgia (Phase I) and Its Augmentation With Pregabalin in Trazodone Partial Responders (Phase II)[NCT00791739]Phase 466 participants (Actual)Interventional2008-04-30Completed
Evaluation of Spa Therapy in the Treatment of Fibromyalgia : a Randomized, Controlled, Open Multicenter Study[NCT02265029]220 participants (Actual)Interventional2014-09-30Completed
Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313]152 participants (Actual)Interventional2015-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for trazodone and Fibromyalgia

ArticleYear
Trazodone for the treatment of fibromyalgia: an open-label, 12-week study.
    BMC musculoskeletal disorders, 2010, Sep-10, Volume: 11

    Topics: Adult; Aged; Female; Fibromyalgia; Humans; Hypnotics and Sedatives; Male; Middle Aged; Selective Ser

2010
Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study.
    BMC musculoskeletal disorders, 2011, May-16, Volume: 12

    Topics: Adult; Analgesics; Analysis of Variance; Anti-Anxiety Agents; Antidepressive Agents, Second-Generati

2011
Function of the hypothalamic adrenal axis in patients with fibromyalgia syndrome undergoing mud-pack treatment.
    International journal of clinical pharmacology research, 1999, Volume: 19, Issue:1

    Topics: Adrenocorticotropic Hormone; Antidepressive Agents, Second-Generation; beta-Endorphin; Combined Moda

1999
Function of the hypothalamic adrenal axis in patients with fibromyalgia syndrome undergoing mud-pack treatment.
    International journal of clinical pharmacology research, 1999, Volume: 19, Issue:1

    Topics: Adrenocorticotropic Hormone; Antidepressive Agents, Second-Generation; beta-Endorphin; Combined Moda

1999
Function of the hypothalamic adrenal axis in patients with fibromyalgia syndrome undergoing mud-pack treatment.
    International journal of clinical pharmacology research, 1999, Volume: 19, Issue:1

    Topics: Adrenocorticotropic Hormone; Antidepressive Agents, Second-Generation; beta-Endorphin; Combined Moda

1999
Function of the hypothalamic adrenal axis in patients with fibromyalgia syndrome undergoing mud-pack treatment.
    International journal of clinical pharmacology research, 1999, Volume: 19, Issue:1

    Topics: Adrenocorticotropic Hormone; Antidepressive Agents, Second-Generation; beta-Endorphin; Combined Moda

1999