trazodone has been researched along with Erectile Dysfunction in 33 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The unusual side effect of priapism associated with the antidepressant trazodone has led researchers to evaluate its use for the treatment of erectile dysfunction." | 9.09 | Oral trazodone is not effective therapy for erectile dysfunction: a double-blind, placebo controlled trial. ( Costabile, RA; Spevak, M, 1999) |
| "This study examined the efficacy of trazodone 200 mg/day in patients with erectile dysfunction (ED) without major organic findings." | 9.09 | Trazodone: a double-blind, placebo-controlled, randomized study of its effects in patients with erectile dysfunction without major organic findings. ( Bonte, L; Declercq, G; Demyttenaere, K; Enzlin, P; Vanderborght, W; Vanderschueren, D, 2000) |
| "to assess the effectiveness of oral trazodone 150 mg/d for treatment of erectile dysfunction." | 9.08 | Trazodone, a double blind trial for treatment of erectile dysfunction. ( de la Fuente, RB; Kropman, RF; Lycklama à Nijeholt, AA; Meinhardt, W; Schmitz, PI; Zwartendijk, J, 1997) |
| "The aim of this study was to determine the effectiveness and safety of yohimbine and trazodone used together for the treatment of pure psychogenic impotence." | 9.07 | Effect of yohimbine-trazodone on psychogenic impotence: a randomized, double-blind, placebo-controlled study. ( Barbieri, L; Galli, L; Guazzoni, G; Miani, A; Montorsi, F; Pizzini, G; Rigatti, P; Strambi, LF, 1994) |
| "To determine the efficacy and safety of trazodone in the treatment of erectile dysfunction (ED) in a meta-analysis." | 8.82 | Trazodone for erectile dysfunction: a systematic review and meta-analysis. ( Fink, HA; MacDonald, R; Rutks, IR; Wilt, TJ, 2003) |
| "Anecdotal reports of increased libido and sexual function in patients taking trazodone have led to its empirical use in patients with erectile dysfunction." | 7.69 | Oral trazodone as empirical therapy for erectile dysfunction: a retrospective review. ( Albo, M; Costabile, RA; Lance, R; Steers, WD, 1995) |
| "We describe a physician who successfully treated his own impotence for the last 4 years with trazodone, an antidepressant that may induce priapism." | 7.68 | Treatment of impotence with trazodone: a case report. ( Lal, S; Rios, O; Thavundayil, JX, 1990) |
| "Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine." | 7.68 | Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. ( Bardin, ED; Krieger, JN, 1990) |
| "The unusual side effect of priapism associated with the antidepressant trazodone has led researchers to evaluate its use for the treatment of erectile dysfunction." | 5.09 | Oral trazodone is not effective therapy for erectile dysfunction: a double-blind, placebo controlled trial. ( Costabile, RA; Spevak, M, 1999) |
| "This study examined the efficacy of trazodone 200 mg/day in patients with erectile dysfunction (ED) without major organic findings." | 5.09 | Trazodone: a double-blind, placebo-controlled, randomized study of its effects in patients with erectile dysfunction without major organic findings. ( Bonte, L; Declercq, G; Demyttenaere, K; Enzlin, P; Vanderborght, W; Vanderschueren, D, 2000) |
| "To examine the effects of hypnotic suggestions or the administration of testosterone or trazodone to impotent men with no detectable organic cause for the impotence." | 5.08 | Efficacy of testosterone, trazodone and hypnotic suggestion in the treatment of non-organic male sexual dysfunction. ( Ağargün, MY; Aydin, S; Ercan, M; Kara, H; Odabaş, O, 1996) |
| "to assess the effectiveness of oral trazodone 150 mg/d for treatment of erectile dysfunction." | 5.08 | Trazodone, a double blind trial for treatment of erectile dysfunction. ( de la Fuente, RB; Kropman, RF; Lycklama à Nijeholt, AA; Meinhardt, W; Schmitz, PI; Zwartendijk, J, 1997) |
| "The aim of this study was to determine the effectiveness and safety of yohimbine and trazodone used together for the treatment of pure psychogenic impotence." | 5.07 | Effect of yohimbine-trazodone on psychogenic impotence: a randomized, double-blind, placebo-controlled study. ( Barbieri, L; Galli, L; Guazzoni, G; Miani, A; Montorsi, F; Pizzini, G; Rigatti, P; Strambi, LF, 1994) |
| "We investigated 3 agents with antiserotoninergic activity (oral trazodone, ketanserin and mianserin) in a double-blind randomized placebo controlled design in terms of the effectiveness in erectile dysfunction." | 5.07 | The efficacy of anti-serotoninergic agents in the treatment of erectile dysfunction. ( Altuğ, U; Erol, D; Germiyanoğlu, C; Gürdal, M; Kurt, U; Ozkardeş, H, 1994) |
| "To determine the efficacy and safety of trazodone in the treatment of erectile dysfunction (ED) in a meta-analysis." | 4.82 | Trazodone for erectile dysfunction: a systematic review and meta-analysis. ( Fink, HA; MacDonald, R; Rutks, IR; Wilt, TJ, 2003) |
| "To determine the affinities of human penile alpha-adrenoceptors and cloned human alpha-adrenoceptor subtypes for trazodone, an antidepressant with reported beneficial effects in erectile dysfunction." | 3.70 | Affinity of trazodone for human penile alpha1- andalpha2-adrenoceptors. ( Goepel, M; Krege, S; Michel, MC; Sperling, H, 2000) |
| "Anecdotal reports of increased libido and sexual function in patients taking trazodone have led to its empirical use in patients with erectile dysfunction." | 3.69 | Oral trazodone as empirical therapy for erectile dysfunction: a retrospective review. ( Albo, M; Costabile, RA; Lance, R; Steers, WD, 1995) |
| "We describe a physician who successfully treated his own impotence for the last 4 years with trazodone, an antidepressant that may induce priapism." | 3.68 | Treatment of impotence with trazodone: a case report. ( Lal, S; Rios, O; Thavundayil, JX, 1990) |
| "Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine." | 3.68 | Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. ( Bardin, ED; Krieger, JN, 1990) |
| "Bupropion SR in the treatment of PTSD had no significant effect in the current sample." | 2.73 | A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder. ( Becker, ME; Beckham, JC; Bukenya, DS; Dennis, MF; Hertzberg, MA; Moore, SD, 2007) |
| "To investigate the efficacy in treating erectile dysfunction and to develop a natural drug without complications, the results of ginseng treatments are compared to placebo and other drug." | 2.68 | Clinical efficacy of Korean red ginseng for erectile dysfunction. ( Choi, HK; Rha, KH; Seong, DH, 1995) |
| "Trazodone is a second-generation antidepressant approved by the U." | 1.39 | A nationwide population study of trazodone use in urology patients. ( Chen, KK; Chen, TJ; Cheng, WM; Lin, AT; Lin, TP, 2013) |
| "Trazodone hydrochloride is an oral antidepressant agent which has been associated with the improvement of erections in impotent men and the development of prolonged erections or priapism in potent men." | 1.28 | Effects of intracavernosal trazodone hydrochloride: animal and human studies. ( Azadzoi, KM; Goldstein, I; Krane, RJ; Payton, T, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.06) | 18.7374 |
| 1990's | 15 (45.45) | 18.2507 |
| 2000's | 13 (39.39) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, H | 1 |
| Berdahl, C | 1 |
| Bresee, C | 1 |
| Moradzadeh, A | 1 |
| Houman, J | 1 |
| Kim, H | 1 |
| Eilber, K | 1 |
| Pevnick, J | 1 |
| Anger, JT | 1 |
| Matz, A | 1 |
| Ambinder, D | 1 |
| Spencer, E | 1 |
| Phillips, J | 1 |
| Wong, NC | 1 |
| Cheng, WM | 1 |
| Lin, TP | 1 |
| Lin, AT | 1 |
| Chen, KK | 1 |
| Chen, TJ | 1 |
| Chen, CJ | 1 |
| Kuo, TB | 1 |
| Tseng, YJ | 1 |
| Yang, CC | 1 |
| Thomas, JA | 1 |
| Brushwood, DB | 1 |
| Kimberlin, CL | 1 |
| Fink, HA | 2 |
| MacDonald, R | 1 |
| Rutks, IR | 1 |
| Wilt, TJ | 2 |
| Padma-Nathan, H | 1 |
| Christ, G | 1 |
| Adaikan, G | 1 |
| Becher, E | 1 |
| Brock, G | 1 |
| Carrier, S | 1 |
| Carson, C | 1 |
| Corbin, J | 1 |
| Francis, S | 1 |
| DeBusk, R | 1 |
| Eardley, I | 1 |
| Hedlund, H | 1 |
| Hutter, A | 1 |
| Jackson, G | 1 |
| Kloner, R | 1 |
| Lin, CS | 1 |
| Lin, S | 1 |
| McVary, K | 1 |
| McCullough, A | 1 |
| Nehra, A | 1 |
| Porst, H | 1 |
| Schulman, C | 1 |
| Seftel, A | 1 |
| Sharlip, I | 1 |
| Stief, C | 1 |
| Teloken, C | 1 |
| Becker, ME | 1 |
| Hertzberg, MA | 1 |
| Moore, SD | 1 |
| Dennis, MF | 1 |
| Bukenya, DS | 1 |
| Beckham, JC | 1 |
| Taneja, R | 1 |
| Lance, R | 1 |
| Albo, M | 1 |
| Costabile, RA | 2 |
| Steers, WD | 1 |
| Tordjman, G | 1 |
| Montorsi, F | 1 |
| Strambi, LF | 1 |
| Guazzoni, G | 1 |
| Galli, L | 1 |
| Barbieri, L | 1 |
| Rigatti, P | 1 |
| Pizzini, G | 1 |
| Miani, A | 1 |
| Kurt, U | 1 |
| Ozkardeş, H | 1 |
| Altuğ, U | 1 |
| Germiyanoğlu, C | 1 |
| Gürdal, M | 1 |
| Erol, D | 1 |
| Chiang, PH | 1 |
| Tsai, EM | 1 |
| Chiang, CP | 1 |
| Choi, HK | 1 |
| Seong, DH | 1 |
| Rha, KH | 1 |
| Aydin, S | 1 |
| Odabaş, O | 1 |
| Ercan, M | 1 |
| Kara, H | 1 |
| Ağargün, MY | 1 |
| Giuliano, F | 1 |
| Meinhardt, W | 1 |
| Schmitz, PI | 1 |
| Kropman, RF | 1 |
| de la Fuente, RB | 1 |
| Lycklama à Nijeholt, AA | 1 |
| Zwartendijk, J | 1 |
| Spevak, M | 1 |
| Trummer, H | 1 |
| Krege, S | 1 |
| Goepel, M | 1 |
| Sperling, H | 1 |
| Michel, MC | 1 |
| Enzlin, P | 1 |
| Vanderschueren, D | 1 |
| Bonte, L | 1 |
| Vanderborght, W | 1 |
| Declercq, G | 1 |
| Demyttenaere, K | 1 |
| Andersson, KE | 1 |
| Lenk, S | 1 |
| Adaikan, PG | 2 |
| Ng, SC | 1 |
| Chan, C | 1 |
| Ratnam, SS | 2 |
| Lau, LC | 1 |
| Vasatha, KS | 1 |
| Susheela, K | 1 |
| Azadzoi, KM | 1 |
| Payton, T | 1 |
| Krane, RJ | 1 |
| Goldstein, I | 1 |
| Lal, S | 1 |
| Rios, O | 1 |
| Thavundayil, JX | 1 |
| Bardin, ED | 1 |
| Krieger, JN | 1 |
| Tasini, M | 1 |
6 reviews available for trazodone and Erectile Dysfunction
| Article | Year |
|---|---|
Pharmacological aspects of erectile dysfunction.
Topics: Adult; Aged; Alprostadil; Apomorphine; Drug Interactions; Erectile Dysfunction; Humans; Male; Middle | 2002 |
Trazodone for erectile dysfunction: a systematic review and meta-analysis.
Topics: Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Erectile Dysfunction; Hu | 2003 |
[Treatment of impotence].
Topics: Alprostadil; Androgens; Attitude to Health; Erectile Dysfunction; Humans; Male; Papaverine; Penile P | 1994 |
[Treatment per os of disorders of erection].
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Antidepressive Agents, Second-Generation; Apomor | 1997 |
[Oral therapy of erectile dysfunction].
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Apomorphine; Dopamine Agonists; Erectile | 2000 |
Pharmacology of erectile function and dysfunction.
Topics: Animals; Apomorphine; Dopamine Agonists; Endothelins; Erectile Dysfunction; Humans; Male; Penile Ere | 2001 |
10 trials available for trazodone and Erectile Dysfunction
| Article | Year |
|---|---|
A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder.
Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Attention; Bupropion; Chronic | 2007 |
A rational combination pharmacotherapy in men with erectile dysfunction who initially failed to oral sildenafil citrate alone: a pilot study.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Coitus; Combined Modality Therapy; Dose-Respo | 2007 |
Effect of yohimbine-trazodone on psychogenic impotence: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Oral; Adult; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Ere | 1994 |
The efficacy of anti-serotoninergic agents in the treatment of erectile dysfunction.
Topics: Adult; Aged; Double-Blind Method; Erectile Dysfunction; Humans; Ketanserin; Male; Mianserin; Middle | 1994 |
The role of trazodone in the treatment of erectile dysfunction.
Topics: Adult; Aged; Animals; Erectile Dysfunction; Humans; In Vitro Techniques; Male; Middle Aged; Muscle C | 1994 |
Clinical efficacy of Korean red ginseng for erectile dysfunction.
Topics: Adult; Aged; Erectile Dysfunction; Humans; Male; Middle Aged; Panax; Penile Erection; Plant Extracts | 1995 |
Efficacy of testosterone, trazodone and hypnotic suggestion in the treatment of non-organic male sexual dysfunction.
Topics: Adult; Erectile Dysfunction; Humans; Hypnosis; Libido; Male; Middle Aged; Selective Serotonin Reupta | 1996 |
Trazodone, a double blind trial for treatment of erectile dysfunction.
Topics: Adrenergic alpha-Antagonists; Double-Blind Method; Erectile Dysfunction; Humans; Male; Placebos; Sel | 1997 |
Oral trazodone is not effective therapy for erectile dysfunction: a double-blind, placebo controlled trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Cros | 1999 |
Trazodone: a double-blind, placebo-controlled, randomized study of its effects in patients with erectile dysfunction without major organic findings.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Depression; Double-Blind Method; | 2000 |
17 other studies available for trazodone and Erectile Dysfunction
| Article | Year |
|---|---|
Priapism from Recreational Intracavernosal Injections in a High-Risk Metropolitan Community.
Topics: Adult; Emergency Service, Hospital; Erectile Dysfunction; Humans; Illicit Drugs; Injections; Los Ang | 2019 |
Review of Priapism Litigation in the United States.
Topics: Erectile Dysfunction; Humans; Insurance Claim Review; Male; Malpractice; Priapism; Psychotropic Drug | 2021 |
A nationwide population study of trazodone use in urology patients.
Topics: Adolescent; Adult; Aged; Erectile Dysfunction; Humans; Male; Middle Aged; Off-Label Use; Phosphodies | 2013 |
Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Case-Control Studies; Electrocardiography; Erectile | 2009 |
Voluntary undertaking rule and duty to warn.
Topics: Duty to Warn; Erectile Dysfunction; Humans; Male; Patient Education as Topic; Pharmacists; Postopera | 2002 |
Is antidepressant plus sildenafil a recipe for priapism?
Topics: Antidepressive Agents; Drug Therapy, Combination; Erectile Dysfunction; Humans; Male; Phosphodiester | 2004 |
Pharmacotherapy for erectile dysfunction.
Topics: alpha-MSH; Apomorphine; Dopamine Agonists; Drug Therapy, Combination; Erectile Dysfunction; Humans; | 2004 |
Priapism with trazodone (Desyrel).
Topics: Adult; Erectile Dysfunction; Humans; Male; Middle Aged; Penis; Piperazines; Priapism; Trazodone | 1984 |
Oral trazodone as empirical therapy for erectile dysfunction: a retrospective review.
Topics: Administration, Oral; Adult; Affect; Aged; Aged, 80 and over; Chi-Square Distribution; Erectile Dysf | 1995 |
Affinity of trazodone for human penile alpha1- andalpha2-adrenoceptors.
Topics: Antidepressive Agents, Second-Generation; Erectile Dysfunction; Humans; Male; Penis; Receptors, Adre | 2000 |
[Progress in therapy of erectile dysfunction. New orally administered drugs].
Topics: Administration, Oral; Apomorphine; Clinical Trials as Topic; Erectile Dysfunction; Humans; Male; Phe | 2002 |
Oral trazodone in the treatment of total secondary impotence in a diabetic patient.
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Erectile Dysfunction; Humans; Male; Middle Aged; Ti | 1991 |
[Neurotransmitters of penile erection other than vasoactive intestinal polypeptide. Physiologic data and therapeutic consequences].
Topics: Alprostadil; Erectile Dysfunction; Humans; Male; Neurotransmitter Agents; Papaverine; Penile Erectio | 1990 |
Effects of intracavernosal trazodone hydrochloride: animal and human studies.
Topics: Adrenergic alpha-Antagonists; Adult; Animals; Erectile Dysfunction; Humans; Male; Penile Erection; P | 1990 |
Treatment of impotence with trazodone: a case report.
Topics: Erectile Dysfunction; Humans; Male; Middle Aged; Penile Erection; Trazodone | 1990 |
Pharmacological priapism: comparison of trazodone- and papaverine-associated cases.
Topics: Depressive Disorder; Erectile Dysfunction; Humans; Male; Papaverine; Priapism; Trazodone | 1990 |
Complex partial seizures in a patient receiving trazodone.
Topics: Carbamazepine; Depressive Disorder; Epilepsy, Temporal Lobe; Erectile Dysfunction; Humans; Male; Mid | 1986 |