trazodone has been researched along with Drug Withdrawal Symptoms in 20 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trazodone is a non-tricyclic antidepressant drug with specific antagonistic activities at 5-HT(2) and alpha-1 adrenoceptors." | 2.69 | Combined use of trazodone-naltrexone versus clonidine-naltrexone in rapid withdrawal from methadone treatment. A comparative inpatient study. ( Conte, G; De Risio, S; Pozzi, G, 2000) |
| "Alternatively, tricyclic antidepressant withdrawal symptoms often respond to anticholinergics, such as atropine or benztropine mesylate." | 2.40 | Antidepressant withdrawal reactions. ( Wolfe, RM, 1997) |
| "Intensity of withdrawal symptoms was evaluated by tail-flick assay latencies and three behavioural measurements (rearing, jumping and grooming) in each group." | 1.32 | Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice. ( Backler, MM; Bar-Hamburger, R; Herman, I; Pick, CG; Rigai, T; Schreiber, S; Shamir, D, 2003) |
| "Three cases developed withdrawal symptoms of trazodone despite gradual discontinuation of therapeutic doses of the drug." | 1.29 | Mechanisms of the development of trazodone withdrawal symptoms. ( Fukushima, Y; Ishida, M; Kaneko, S; Otani, K; Tanaka, O; Yasui, N, 1994) |
| "Trazodone is a new psychotropic drug which has a marked norepinephrine receptor blocking power; moreover, it inhibits serotonin reuptake and was fully effective in the treatment of man's withdrawal syndrome (17 alcoholic inpatients)." | 1.26 | Alcohol withdrawal syndrome: treatment with trazodone. ( Albano, C; Farelli, S; Maffini, M; Roccatagliata, G, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (50.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schreiber, S | 1 |
| Backler, MM | 1 |
| Herman, I | 1 |
| Shamir, D | 1 |
| Rigai, T | 1 |
| Bar-Hamburger, R | 1 |
| Pick, CG | 1 |
| Le Bon, O | 1 |
| Murphy, JR | 1 |
| Staner, L | 1 |
| Hoffmann, G | 1 |
| Kormoss, N | 1 |
| Kentos, M | 1 |
| Dupont, P | 1 |
| Lion, K | 1 |
| Pelc, I | 1 |
| Verbanck, P | 1 |
| Borras, L | 1 |
| de Timary, P | 1 |
| Constant, EL | 1 |
| Huguelet, P | 1 |
| Eytan, A | 1 |
| Roccatagliata, G | 1 |
| Albano, C | 1 |
| Maffini, M | 1 |
| Farelli, S | 1 |
| Montgomery, I | 1 |
| Oswald, I | 1 |
| Morgan, K | 1 |
| Adam, K | 1 |
| Otani, K | 1 |
| Tanaka, O | 1 |
| Kaneko, S | 1 |
| Ishida, M | 1 |
| Yasui, N | 1 |
| Fukushima, Y | 1 |
| Ansseau, M | 1 |
| De Roeck, J | 1 |
| Wolfe, RM | 1 |
| Mirassou, MM | 1 |
| Rickels, K | 1 |
| Schweizer, E | 1 |
| Garcia España, F | 1 |
| Case, G | 1 |
| DeMartinis, N | 1 |
| Greenblatt, D | 1 |
| Pozzi, G | 1 |
| Conte, G | 1 |
| De Risio, S | 1 |
| Fedeli, S | 1 |
| Ferri, FA | 1 |
| Fogari, R | 1 |
| Valeri, P | 1 |
| Pimpinella, G | 1 |
| Troiani, MP | 1 |
| Morrone, LA | 1 |
| Romanelli, L | 1 |
| Ostow, M | 1 |
| Silvestrini, B | 1 |
| Montalbetti, DJ | 1 |
| Zis, AP | 1 |
| Peabody, CA | 1 |
| Menza, MA | 1 |
| Theilman, SB | 1 |
| Christenbury, MM | 1 |
| Small, GW | 1 |
| Purcell, JJ | 1 |
1 review available for trazodone and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Antidepressant withdrawal reactions.
Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clomipramine; Cyclohe | 1997 |
5 trials available for trazodone and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Double-blind, placebo-controlled study of the efficacy of trazodone in alcohol post-withdrawal syndrome: polysomnographic and clinical evaluations.
Topics: Adolescent; Adult; Aged; Alcoholism; Antidepressive Agents, Second-Generation; Central Nervous Syste | 2003 |
Trazodone in benzodiazepine dependence.
Topics: Adult; Ambulatory Care; Benzodiazepines; Drug Administration Schedule; Female; Hospitalization; Huma | 1993 |
Trazodone and valproate in patients discontinuing long-term benzodiazepine therapy: effects on withdrawal symptoms and taper outcome.
Topics: Adult; Aged; Anti-Anxiety Agents; Antimanic Agents; Benzodiazepines; Double-Blind Method; Female; Hu | 1999 |
Combined use of trazodone-naltrexone versus clonidine-naltrexone in rapid withdrawal from methadone treatment. A comparative inpatient study.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analysis of Variance; Clonidine; Drug Therapy, Combina | 2000 |
Blockade of acute opiate-withdrawal symptoms by trazodone treatment.
Topics: Acute Disease; Anxiety; Clinical Trials as Topic; Heroin Dependence; Humans; Piperazines; Substance | 1979 |
14 other studies available for trazodone and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Disease Models, An | 2003 |
Successful treatment of alcohol withdrawal with trazodone.
Topics: Adult; Alcoholism; Antidepressive Agents, Second-Generation; Central Nervous System Depressants; Eth | 2006 |
Alcohol withdrawal syndrome: treatment with trazodone.
Topics: Adult; Brain; Ethanol; Female; Humans; Male; Neurotransmitter Agents; Piperazines; Substance Withdra | 1980 |
Trazodone enhances sleep in subjective quality but not in objective duration.
Topics: Aged; Electroencephalography; Electromyography; Female; Humans; Male; Middle Aged; Piperazines; Slee | 1983 |
Mechanisms of the development of trazodone withdrawal symptoms.
Topics: Adult; Female; Humans; Male; Middle Aged; Serotonin; Substance Withdrawal Syndrome; Trazodone | 1994 |
Rectal antidepressant medication in the treatment of depression.
Topics: Adult; Depressive Disorder; Humans; Male; Postoperative Complications; Pyloric Stenosis; Recurrence; | 1998 |
Effects of trazodone and m-chlorophenylpiperazine (m-CPP) on acute dependence in mice.
Topics: Acute Disease; Animals; Behavior, Animal; Male; Mice; Morphine Dependence; Piperazines; Receptors, S | 1991 |
Pharmacologic treatment of manic and depressive illness.
Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bipolar Disorder; Central Nervous System Sti | 1985 |
Trazodone and the mental pain hypothesis of depression.
Topics: Depressive Disorder; Ethanol; Humans; Receptors, Serotonin; Serotonin; Substance Withdrawal Syndrome | 1986 |
Cholinergic rebound following trazodone withdrawal?
Topics: Adult; Aged; Female; Humans; Male; Parasympatholytics; Substance Withdrawal Syndrome; Trazodone | 1988 |
Trazodone withdrawal and formication.
Topics: Aged; Depressive Disorder; Humans; Male; Paresthesia; Substance Withdrawal Syndrome; Trazodone | 1987 |
Withdrawal syndrome in a depressed patient treated with trazodone.
Topics: Adult; Anxiety Disorders; Depersonalization; Depressive Disorder; Dreams; Humans; Male; Sleep Initia | 1986 |
Hypomania following withdrawal of trazodone.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Substance Withdrawal Syndrome; Trazodo | 1986 |
Trazodone and cocaine abuse.
Topics: Adult; Cocaine; Humans; Male; Piperazines; Substance Withdrawal Syndrome; Substance-Related Disorder | 1985 |