Page last updated: 2024-11-05

trazodone and Drug Overdose

trazodone has been researched along with Drug Overdose in 23 studies

Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.

Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Research Excerpts

ExcerptRelevanceReference
"BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone."5.48Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018)
"Priapism is a urologic disorder and medical emergency with a variety of known etiologies including the use of psychotropic medications."5.30Priapism following trazodone overdose with cocaine use. ( Henderson, S; Markowitz, JS; Myrick, H, 1998)
"She was found to have seizure activity without cerebral edema."1.51Arrhythmias in Severe Trazodone Overdose. ( Lee, MY; Soe, KK, 2019)
"Trazodone is an atypical antidepressant with no established safety in children."1.51Unintentional trazodone overdoses in children ≤6 years of age: data from poison center over a period of 16 years. ( El Zahran, T; Geller, RJ; Herrington, L; Hon, S; Morgan, BW, 2019)
"BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone."1.48Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018)
"The seizure was successfully treated with benzodiazepines."1.32Seizure secondary to citalopram overdose. ( Cuenca, PJ; Hoefle, JD; Holt, KR, 2004)
"Priapism is a urologic disorder and medical emergency with a variety of known etiologies including the use of psychotropic medications."1.30Priapism following trazodone overdose with cocaine use. ( Henderson, S; Markowitz, JS; Myrick, H, 1998)
"We present a patient with BAL-confirmed eosinophilic pneumonia (EP) and respiratory failure after a trazodone overdose."1.29Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose. ( Roth, BJ; Sakata, V; Salerno, SM; Strong, JS, 1995)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (26.09)18.2507
2000's9 (39.13)29.6817
2010's7 (30.43)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Nendumba, G1
Boland, L1
Haufroid, V1
Laterre, PF1
Hantson, P1
Soe, KK1
Lee, MY1
Little, K1
Lin, CM1
Reynolds, PM1
El Zahran, T1
Morgan, BW1
Hon, S1
Herrington, L1
Geller, RJ1
Perza, MN1
Schneider, LA1
Rosini, JM1
Cooper, CM1
Baron, JM1
Waldo, SW1
Treit, K1
Goldschlager, N1
Devresse, A1
Maldague, P1
Coulier, B1
Pierard, F1
Gielen, I1
Cuenca, PJ1
Holt, KR1
Hoefle, JD1
Bateman, DN1
Chick, J1
Good, AM1
Kelly, CA1
Masterton, G1
Lu, BY1
Woofter, C1
Escalona, R1
Vantaggiato, DR1
De Giovanni, N1
Dattilo, PB1
Nordin, C1
Chung, KJ1
Wang, YC1
Liu, BM1
Supernaw, RB1
Service, JA1
Waring, WS1
Salerno, SM1
Strong, JS1
Roth, BJ1
Sakata, V1
Dharnidharka, VR1
Nadeau, K1
Cannon, CL1
Harris, HW1
Rosen, S1
Myrick, H1
Markowitz, JS1
Henderson, S1
Levenson, JL1
Vanpee, D1
Laloyaux, P1
Gillet, JB1
Roberge, RJ1
Luellen, JR1
Reed, S1
Adson, DE1
Erickson-Birkedahl, S1
Kotlyar, M1
Balestrieri, G1
Cerudelli, B1
Ciaccio, S1
Rizzoni, D1

Reviews

1 review available for trazodone and Drug Overdose

ArticleYear
Ciprofloxacin overdose: acute renal failure with prominent apoptotic changes.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1998, Volume: 31, Issue:4

    Topics: Acute Kidney Injury; Adolescent; Anti-Infective Agents; Antidepressive Agents, Second-Generation; Ap

1998

Other Studies

22 other studies available for trazodone and Drug Overdose

ArticleYear
Intravenous Lipid Emulsion in a Case of Trazodone Overdose.
    The primary care companion for CNS disorders, 2022, 03-08, Volume: 24, Issue:2

    Topics: Antidepressive Agents; Drug Overdose; Fat Emulsions, Intravenous; Humans; Trazodone

2022
Arrhythmias in Severe Trazodone Overdose.
    The American journal of case reports, 2019, Dec-27, Volume: 20

    Topics: Anti-Anxiety Agents; Anticonvulsants; Bundle-Branch Block; Dopamine; Drug Overdose; Electrocardiogra

2019
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose.
    The American journal of case reports, 2018, May-25, Volume: 19

    Topics: Benzodiazepines; Bupropion; Cyproheptadine; Dopamine Uptake Inhibitors; Drug Overdose; Fluoxetine; H

2018
Unintentional trazodone overdoses in children ≤6 years of age: data from poison center over a period of 16 years.
    Clinical toxicology (Philadelphia, Pa.), 2019, Volume: 57, Issue:1

    Topics: Child, Preschool; Dose-Response Relationship, Drug; Drug Overdose; Female; Georgia; Humans; Male; Po

2019
Suspected tricyclic antidepressant overdose successfully treated with lipids.
    Journal of emergency nursing, 2013, Volume: 39, Issue:3

    Topics: Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Doxepin; Drug Overdose; Fat Em

2013
Case records of the Massachusetts General Hospital. Case 4-2015. A 49-year-old man with obtundation followed by agitation and acidosis.
    The New England journal of medicine, 2015, Jan-29, Volume: 372, Issue:5

    Topics: Acidosis; Calcium Oxalate; Chromatography, High Pressure Liquid; Consciousness Disorders; Diagnosis,

2015
Possible acute myocardial infarction in a hypothermic patient.
    Archives of internal medicine, 2011, Sep-12, Volume: 171, Issue:16

    Topics: Acute Disease; Anticonvulsants; Antimanic Agents; Benzodiazepines; Bipolar Disorder; Drug Overdose;

2011
Focal parietal necrosis of the sigmoid due to atypical neuroleptics: a case report.
    Acta gastro-enterologica Belgica, 2012, Volume: 75, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Citalopram

2012
Seizure secondary to citalopram overdose.
    The Journal of emergency medicine, 2004, Volume: 26, Issue:2

    Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Anticonvulsants; Antidepressive Agents, Second-Generation;

2004
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
    European journal of clinical pharmacology, 2004, Volume: 60, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Ove

2004
A case of prolonged peyote-induced psychosis resolved by sleep.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:10

    Topics: Drug Overdose; Hallucinogens; Humans; Indians, North American; Male; Mescaline; Middle Aged; Psychos

2004
Suicide by multidrug ingestion: hypothesis on the role played by the self-administration of activated charcoal.
    The American journal of forensic medicine and pathology, 2007, Volume: 28, Issue:1

    Topics: Aged; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Charcoal; Dipyrone; D

2007
Prolonged QT associated with an overdose of trazodone.
    The Journal of clinical psychiatry, 2007, Volume: 68, Issue:8

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Depression; Drug Overdose; Electrocardio

2007
Management of ventricular dysrhythmia secondary to trazodone overdose.
    The Journal of emergency medicine, 2008, Volume: 35, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Drug Overdose; Electric Countershock; Female; Humans; Magnesium Sulfa

2008
QT Prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Atrioventricular Node; Drug Overdose; Electrocardio

2008
Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose.
    American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:6 Pt 1

    Topics: Acute Disease; Adult; Drug Overdose; Female; Humans; Lung; Pulmonary Eosinophilia; Radiography; Resp

1995
Priapism following trazodone overdose with cocaine use.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1998, Volume: 10, Issue:2

    Topics: Adult; Cardiovascular Agents; Cocaine; Cocaine-Related Disorders; Drug Interactions; Drug Overdose;

1998
Prolonged QT interval after trazodone overdose.
    The American journal of psychiatry, 1999, Volume: 156, Issue:6

    Topics: Adult; Charcoal; Drug Overdose; Electrocardiography; Female; Gastric Lavage; Humans; Long QT Syndrom

1999
Seizure and hyponatraemia after overdose of trazadone.
    The American journal of emergency medicine, 1999, Volume: 17, Issue:4

    Topics: Antidepressive Agents, Second-Generation; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Humans; Hyp

1999
False-positive amphetamine screen following a trazodone overdose.
    Journal of toxicology. Clinical toxicology, 2001, Volume: 39, Issue:2

    Topics: Adult; Amphetamine; Antidepressive Agents, Second-Generation; Drug Overdose; False Positive Reaction

2001
An unusual presentation of sertraline and trazodone overdose.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:11

    Topics: Adult; Antidepressive Agents, Second-Generation; Drug Overdose; Humans; Male; Serotonin Syndrome; Se

2001
Hyponatraemia and seizure due to overdose of trazodone.
    BMJ (Clinical research ed.), 1992, Mar-14, Volume: 304, Issue:6828

    Topics: Aged; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Humans; Hyponatremia; Trazodone

1992