trazodone has been researched along with Disease Models, Animal in 23 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule." | 7.67 | Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984) |
| "Thus, it is important to identify the seizure risks associated with antidepressants." | 5.56 | Trazodone increases seizures in a genetic WAG/Rij rat model of absence epilepsy while decreasing them in penicillin-evoked focal seizure model. ( Aygun, H, 2020) |
| " First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances." | 5.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| "Trazodone hydrochloride is used in the treatment of neuropathic pain." | 3.72 | Trazodone hydrochloride attenuates thermal hyperalgesia in a chronic constriction injury rat model. ( Okuda, K; Takanishi, T; Ueda, S; Yoshimoto, K, 2003) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| "Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule." | 3.67 | Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984) |
| " The results indicate that chronic administration of imipramine or of electroshock led to the abolition of the behavioural depression and of the EEG synchronisation induced by clonidine." | 3.66 | Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat. ( Passarelli, F; Scotti de Carolis, A, 1983) |
| "Insomnia is a common and disabling complaint for which there is a need for improved treatments." | 2.73 | A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers. ( Hutson, PH; Ivarsson, M; Nutt, DJ; Paterson, LM; Wilson, SJ, 2007) |
| " In a 9 week dosing regimen, trazodone decreased microglial NLRP3 inflammasome expression and phosphorylated p38 mitogen-activated protein kinase levels, which correlated with the NLRP3 inflammasome, the UPR effector ATF4, and total tau levels." | 1.72 | Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice. ( Cella, C; de Oliveira, P; Dijk, DJ; Gilmour, G; Locker, N; Mendis, A; Ravindran, KKG; Wafford, K; Winsky-Sommerer, R, 2022) |
| "Clemizole and trazodone were previously identified in a larval zebrafish model for Dravet syndrome." | 1.72 | Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder. ( Baraban, SC; Moog, M, 2022) |
| "Neuropathic pain is a chronic debilitating condition caused by injury or disease of the nerves of the somatosensory system." | 1.62 | Synergistic interaction between trazodone and gabapentin in rodent models of neuropathic pain. ( Amato, A; Di Giorgio, FP; di Matteo, A; Durando, L; Garrone, B; Milanese, C; Pistillo, L; Tongiani, S, 2021) |
| "Thus, it is important to identify the seizure risks associated with antidepressants." | 1.56 | Trazodone increases seizures in a genetic WAG/Rij rat model of absence epilepsy while decreasing them in penicillin-evoked focal seizure model. ( Aygun, H, 2020) |
| " First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances." | 1.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| " Following recovery, animals were dosed with caffeine (10 mg/kg) alone or in combination with zolpidem (10 mg/kg) or trazodone (20 mg/kg)." | 1.35 | Characterisation of the effects of caffeine on sleep in the rat: a potential model of sleep disruption. ( Hutson, PH; Ivarsson, M; Nutt, DJ; Paterson, LM; Wilson, SJ, 2009) |
| "Intensity of withdrawal symptoms was evaluated by tail-flick assay latencies and three behavioural measurements (rearing, jumping and grooming) in each group." | 1.32 | Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice. ( Backler, MM; Bar-Hamburger, R; Herman, I; Pick, CG; Rigai, T; Schreiber, S; Shamir, D, 2003) |
| "Bilaterally olfactory bulbectomized rats were compared with intact rats in their responsiveness to the acute and chronic administration of nomifensine and trazodone in the learned immobility test of Porsolt." | 1.27 | Effect of bilateral olfactory bulbectomy in the rat, alone or in combination with antidepressants, on the learned immobility model of depression. ( Earley, B; Górka, Z; Leonard, BE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (17.39) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 7 (30.43) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| de Oliveira, P | 1 |
| Cella, C | 1 |
| Locker, N | 1 |
| Ravindran, KKG | 1 |
| Mendis, A | 1 |
| Wafford, K | 1 |
| Gilmour, G | 1 |
| Dijk, DJ | 1 |
| Winsky-Sommerer, R | 1 |
| Moog, M | 1 |
| Baraban, SC | 1 |
| Schreiber, S | 2 |
| Pick, CG | 2 |
| Aygun, H | 1 |
| Elhesaisy, N | 1 |
| Swidan, S | 1 |
| Garrone, B | 1 |
| di Matteo, A | 1 |
| Amato, A | 1 |
| Pistillo, L | 1 |
| Durando, L | 1 |
| Milanese, C | 1 |
| Di Giorgio, FP | 1 |
| Tongiani, S | 1 |
| Halliday, M | 1 |
| Radford, H | 1 |
| Zents, KAM | 1 |
| Molloy, C | 1 |
| Moreno, JA | 1 |
| Verity, NC | 1 |
| Smith, E | 1 |
| Ortori, CA | 1 |
| Barrett, DA | 1 |
| Bushell, M | 1 |
| Mallucci, GR | 1 |
| Paterson, LM | 2 |
| Wilson, SJ | 2 |
| Nutt, DJ | 2 |
| Hutson, PH | 2 |
| Ivarsson, M | 2 |
| Gaur, V | 1 |
| Kumar, A | 1 |
| Fernández-Dueñas, V | 1 |
| Poveda, R | 1 |
| Fernández, A | 1 |
| Sánchez, S | 1 |
| Planas, E | 1 |
| Ciruela, F | 1 |
| Marinescu, IP | 1 |
| Predescu, A | 1 |
| Udriştoiu, T | 1 |
| Marinescu, D | 1 |
| Borowicz, KK | 1 |
| Gurdziel, E | 1 |
| Czuczwar, SJ | 1 |
| Backler, MM | 1 |
| Herman, I | 1 |
| Shamir, D | 1 |
| Rigai, T | 1 |
| Bar-Hamburger, R | 1 |
| Okuda, K | 1 |
| Takanishi, T | 1 |
| Yoshimoto, K | 1 |
| Ueda, S | 1 |
| Abdel-Salam, OM | 1 |
| Nofal, SM | 1 |
| El-Shenawy, SM | 1 |
| Leonard, BE | 2 |
| Hingtgen, JN | 1 |
| Hendrie, HC | 1 |
| Aprison, MH | 1 |
| Passarelli, F | 1 |
| Scotti de Carolis, A | 1 |
| Katkov, YA | 1 |
| Otmakhova, NA | 1 |
| Gurevich, EV | 1 |
| Nesterova, IV | 1 |
| Bobkova, NV | 1 |
| Górka, Z | 1 |
| Earley, B | 1 |
1 trial available for trazodone and Disease Models, Animal
| Article | Year |
|---|---|
A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers.
Topics: Adult; Animals; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Disease Models, Ani | 2007 |
22 other studies available for trazodone and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Disease Progression; Humans; Inflammasomes; Male | 2022 |
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder.
Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Humans; Larva; Munc18 Proteins; Ra | 2022 |
Trazodone and mirtazapine: A possible opioid involvement in their use (at low dose) for sleep?
Topics: Analgesics; Analgesics, Opioid; Animals; Antidepressive Agents; Depression; Disease Models, Animal; | 2020 |
Trazodone increases seizures in a genetic WAG/Rij rat model of absence epilepsy while decreasing them in penicillin-evoked focal seizure model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, | 2020 |
Trazodone Loaded Lipid Core Poly (ε-caprolactone) Nanocapsules: Development, Characterization and in Vivo Antidepressant Effect Evaluation.
Topics: Animals; Antidepressive Agents; Delayed-Action Preparations; Depression; Disease Models, Animal; Dru | 2020 |
Synergistic interaction between trazodone and gabapentin in rodent models of neuropathic pain.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Depressive Disorder, Major; Disease Models, Animal; Drug S | 2021 |
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Topics: Animals; Behavior, Animal; Chalcones; Disease Models, Animal; eIF-2 Kinase; Frontotemporal Dementia; | 2017 |
Characterisation of the effects of caffeine on sleep in the rat: a potential model of sleep disruption.
Topics: Animals; Body Temperature; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Elec | 2009 |
Protective effect of desipramine, venlafaxine and trazodone against experimental animal model of transient global ischemia: possible involvement of NO-cGMP pathway.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Brain; Catalase; Cyclic GMP; Cyclohe | 2010 |
Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain.
Topics: Acetaminophen; Analgesics; Animals; Disease Models, Animal; Drug Combinations; Fentanyl; Male; Mice; | 2011 |
Comparative study of neuroprotective effect of tricyclics vs. trazodone on animal model of depressive disorder.
Topics: Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Dexamethasone; Disease Models, Anima | 2012 |
Trazodone reduces the anticonvulsant action of certain classical antiepileptics in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; Drug Interactions; Elec | 2012 |
Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Disease Models, An | 2003 |
Trazodone hydrochloride attenuates thermal hyperalgesia in a chronic constriction injury rat model.
Topics: Animals; Antidepressive Agents, Second-Generation; Disease Models, Animal; Hot Temperature; Hyperalg | 2003 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
Pharmacology of new antidepressants.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder; Disease Models, Animal; Dopamine; Humans | 1984 |
Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Humans; Male; Methy | 1984 |
Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Depression; Disease Models, Animal; Electroencephalogra | 1983 |
Antidepressants suppress bulbectomy-induced augmentation of voluntary alcohol consumption in C57B1/6j but not in DBA/2j mice.
Topics: Alcohol Drinking; Amitriptyline; Animals; Antidepressive Agents; Arousal; Depressive Disorder; Disea | 1994 |
Effect of bilateral olfactory bulbectomy in the rat, alone or in combination with antidepressants, on the learned immobility model of depression.
Topics: Amygdala; Animals; Depressive Disorder; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Is | 1985 |